The correlation of right 2D:4D finger length ratio to the low-grade inflammation marker IL-6 in children. The Healthy Growth Study

Androutsos, Odysseas; Moschonis, George; Koumpitski, Alexandra; Mantzou, Aimilia; Roma-Giannikou, Eleftheria; Chrousos, George P.; Μanios, Yannis; Kanaka‐Gantenbein, Christina

doi:10.1016/j.earlhumdev.2013.10.003

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…There are public health concerns with rising levels of sedentary lifestyles, obesity and poor levels of fitness across the UK, which have been shown to track from childhood to adulthood [43,44]. Manning and Bundred [45] found that males with a high 2D:4D were at the greatest risk of a heart attack due to lower levels of the male sex hormone testosterone, which is known to protect against heart attack (MI) and this finding has recently been supported in Chinese populations [46]; whereas markers of low-grade inflammation IL-6 which is linked with heart disease, was found to be positively associated with 2D:4D in girls [47]. A high 2D:4D does not suggest a causal link with a MI but may be a marker and could therefore be used as a risk factor [45].…”

Section: Boys Girlsmentioning

confidence: 97%

Digit ratio (2D:4D) and physical fitness (Eurofit test battery) in school children

Ranson

Stratton

Taylor

2015

Early Human Development

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Section: Boys Girlsmentioning

confidence: 97%

Digit ratio (2D:4D) and physical fitness (Eurofit test battery) in school children

Ranson

Stratton

Taylor

2015

Early Human Development

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“…One possibility is that markers of inflammation, such as IL-6, could be linked to both high 2D:4D and to cardiovascular risk. However, IL-6 appears to be associated with high 2D:4D in females only [14]. Here the relationship between 2D:4D and cardiovascular disease is further explored by considering their associations with the positive acute-phase reactant protein fibrinogen which is associated with major trauma such as MI.…”

Section: Introductionmentioning

confidence: 99%

Digit ratio (2D:4D), myocardial infarction and fibrinogen in men

Manning

Bundred

Kasielska‐Trojan³

et al. 2019

Early Human Development

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“…31 While we are not aware of published data for its association with autoimmune diseases, a higher 2D:4D ratio was recently linked to higher levels of the inflammatory marker interleukin 6 in girls aged 9 to 13 years. 32 Here in this first assessment in MS, we examined only men, given marked sexual dimorphism in the ratio and as the association between 2D:4D ratio and prenatal androgens is overall more clearly manifest in men 4 ; however, women may be included in future studies. The results of the current study, if replicated, indicate the need to further explore the association between 2D:4D ratios and inflammatory markers.…”

Section: Ms Clinical Outcomesmentioning

confidence: 99%

The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS

et al. 2015

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The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS ABSTRACT Objective: To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. Methods:We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance.Results: In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p , 0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ratio was not correlated with MS type, age at first symptoms, or MS Severity Score (p . 0.15 for each), and it was not correlated with adult testosterone levels (r 5 0.06, p 5 0.68, n 5 51).Conclusions: During the prenatal period, low androgens could represent a risk factor for MS.

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The correlation of right 2D:4D finger length ratio to the low-grade inflammation marker IL-6 in children. The Healthy Growth Study

Cited by 9 publications

References 26 publications

Digit ratio (2D:4D) and physical fitness (Eurofit test battery) in school children

Digit ratio (2D:4D) and physical fitness (Eurofit test battery) in school children

Digit ratio (2D:4D), myocardial infarction and fibrinogen in men

The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS

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