Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Favarin, Daniely Cornélio; Oliveira, Jhony Robison de; Oliveira, Carlo José Freire; Rogério, Alexandre de Paula

doi:10.1155/2013/576479

Cited by 35 publications

(26 citation statements)

References 152 publications

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“…We also found that TNF-α exhibited high levels of expression in lungs with pancreatitis-associated lung injury and was positively correlated with the extent of lung injury. 20 We also found that TNF-α expression is greater in pancreatitis-associated lung injury compared with normal lung tissue. Inhibiting TNF-α expression might reduce the extent of pancreatitis-associated lung injury.…”

Section: Discussionsupporting

confidence: 53%

“…In addition, alpinetin has an inhibitory effect on LPS-induced inflammation 23 and can inhibit the excretion of the inflammatory mediators TNF-α, IL-6, and IL-1β. Many studies show that extracts from traditional Chinese medicines have an inhibitory effect on lung injury-induced inflammation, including through recruiting neutrophils and excreting inflammatory mediators, 6 , 8 , 16 , 20 but the specific mechanism is not described in detail. In this study, we also found that alpinetin can inhibit inflammation caused by SAP-induced ALI and simultaneously alleviate the extent of SAP-induced ALI; however, the detailed mechanisms remain unknown.…”

Section: Discussionmentioning

confidence: 99%

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The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang¹,

Zhang²,

Chen³

et al. 2016

DDDT

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Characterized by its acute onset, critical condition, poor prognosis, and high mortality rate, severe acute pancreatitis (SAP) can cause multiple organ failure at its early stage, particularly acute lung injury (ALI). The pathogenesis of ALI is diffuse alveolar damage, including an increase in pulmonary microvascular permeability, a decrease in compliance, and invasion of many inflammatory cells. Corticosteroids are the main treatment method for ALI; however, the associated high toxicity and side effects induce pain in patients. Recent studies show that the effective components in many traditional Chinese medicines can effectively inhibit inflammation with few side effects, which can decrease the complications caused by steroid consumption. Based on these observations, the main objective of the current study is to investigate the effect of alpinetin, which is a flavonoid extracted from Alpinia katsumadai Hayata, on treating lung injury induced by SAP and to explore the mechanism underlying the alpinetin-mediated decrease in the extent of ALI. In this study, we have shown through in vitro experiments that a therapeutic dose of alpinetin can promote human pulmonary microvascular endothelial cell proliferation. We have also shown via in vitro and in vivo experiments that alpinetin upregulates aquaporin-1 and, thereby, inhibits tumor necrosis factor-α expression as well as reduces the degree of lung injury. Overall, our study shows that alpinetin alleviates SAP-induced ALI. The likely molecular mechanism includes upregulated aquaporin expression, which inhibits tumor necrosis factor-α and, thus, alleviates SAP-induced ALI.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang¹,

Zhang²,

Chen³

et al. 2016

DDDT

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“…Acute lung injury (ALI) is a life-threatening syndrome that can cause acute hypoxemic respiratory failure, which is characterized by diffuse alveolar damage, increased alveolar capillary membrane permeability, edema, excessive pulmonary inflammation and apoptosis of alveolar epithelial cells [ 1 ]. Studies have shown that excessive apoptosis of type II alveolar epithelial cells can injury the epithelial barrier thus lead to ALI [ 2 , 3 ].…”

Section: Instructionmentioning

confidence: 99%

Long non-coding RNA CASC2 improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis

Shi

Gao

et al. 2018

Cell Biosci

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Background and objectiveApoptosis of lung epithelial cell is implicated in the pathogenesis of acute lung injury (ALI). To study the protective effect and mechanism of cancer susceptibility candidate 2 (CASC2) on reducing lung epithelial cell apoptosis after LPS inducing acute lung injury in mice.Methods and resultsThe ALI mice model was performed by intratracheally instilling with lipopolysaccharide (LPS). The CASC2 expression detected by quantitative real-time polymerase chain reaction was significantly decreased in LPS-induced A549 cell and ALI mice model. LPS induced A549 cell apoptosis, while transfection with pcDNA-CASC2 reversed the increased cell apoptosis, suggesting overexpression of CASC2 inhibited LPS-induced A549 cell apoptosis. In addition, we found that miR-144-3p expression were opposite to CASC2, while Aquaporin-1 (AQP1) expression was opposite to miR-144-3p in LPS-induced A549 cell and ALI mice model. The RNA immunoprecipitation and RNA pull-down assay demonstrated that CASC2 could function as a miR-144-3p decoy. The luciferase reporter assay revealed that AQP1 was a target of miR-144-3p in A549 cell. And then, further in vitro studied showed that CASC2 controlled AQP1 expression by regulating miR-144-3p, and LPS induced A549 cell apoptosis by regulating CASC2/miR-144-3p/AQP1 axis. At last, after injection with lentivirus-expressing CASC2 or control lentivirus, the mice were intratracheally instilled with LPS. Comparing to the mice injected with pcDNA, the mice injected with pcDNA-CASC2 had a significantly reduced lung wet–dry weight ratio.ConclusionsLong non-coding RNA CASC2 improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis.

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“…Several studies have also shown bioactives from medicinal plants function as potential anti-viral agents by boosting the inherent immune system (Ganjhu et al, 2015 ; Mukhtar et al, 2008 ). Furthermore, the anti-inflammatory properties of medicinal plants can reduce severe respiratory distress syndrome and acute cardiac injury, which are the leading cause of COVID-19 morbidities (Cornélio Favarin et al, 2013 ; Liperoti et al, 2017 ). It is known that more than 25,000 plant-based formulations have been used in traditional Indian medicine (Vellingiri et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Traditional medicinal plants against replication, maturation and transmission targets of SARS-CoV-2: computational investigation

Mondal

Natesh

Salam

et al. 2020

Journal of Biomolecular Structure and Dynamics

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COVID-19 is an infectious pandemic caused by the SARS-CoV-2 virus. The critical components of SARS-CoV-2 are the spike protein (S-protein) and the main protease (M pro ). M pro is required for the maturation of the various polyproteins involved in replication and transcription. S-protein helps the SARS-CoV-2 to enter the host cells through the angiotensin-converting enzyme 2 (ACE2). Since ACE2 is required for the binding of SARS-CoV-2 on the host cells, ACE2 inhibitors and blockers have got wider attention, in addition to S-protein and M pro modulators as potential therapeutics for COVID-19. So far, no specific drugs have shown promising therapeutic potential against COVID-19. The current study was undertaken to evaluate the therapeutic potential of traditional medicinal plants against COVID-19. The bioactives from the medicinal plants, along with standard drugs, were screened for their binding against S-protein, M pro and ACE2 targets using molecular docking followed by molecular dynamics. Based on the higher binding affinity compared with standard drugs, bioactives were selected and further analyzed for their pharmacological properties such as drug-likeness, ADME/ T -test, biological activities using in silico tools. The binding energies of several bioactives analyzed with target proteins were relatively comparable and even better than the standard drugs. Based on Lipinski factors and lower binding energies, seven bioactives were further analyzed for their pharmacological and biological characteristics. The selected bioactives were found to have lower toxicity with a higher GI absorption rate and potent anti-inflammatory and anti-viral activities against targets of COVID-19. Therefore, the bioactives from these medicinal plants can be further developed as phytopharmaceuticals for the effective treatment of COVID-19.

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Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Cited by 35 publications

References 152 publications

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Long non-coding RNA CASC2 improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis

Traditional medicinal plants against replication, maturation and transmission targets of SARS-CoV-2: computational investigation

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