Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex

Negrón-Oyarzo, Ignacio; Pérez, Miguel A.; Terreros, Gonzalo; Muñoz, Pablo; Dagnino‐Subiabre, Alexies

doi:10.1016/j.bbr.2013.11.001

Cited by 45 publications

(37 citation statements)

References 65 publications

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“…There is increasing evidence of enhancement of anxiety-like behaviors in rodents, as a consequence of social stress, when measured in the elevated plus-maze test [8, 19–21, 37, 51, 93, 94], although the absence of this anxiogenic effect has also been reported [19, 95]. Similar to our results, other studies have found that defeated mice from both the susceptible and unsusceptible groups displayed anxiety-like behavior in the elevated plus-maze test (e.g.…”

Section: Discussionmentioning

confidence: 99%

Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice

2017

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We have previously observed the impairing effects of chronic social defeat stress (CSDS) on emotional memory in mice. Given the relation between stress and inflammatory processes, we sought to study the effectiveness of the anti-inflammatory indomethacin in reversing the detrimental effects of CSDS on emotional memory in mice. The effects of CSDS and indomethacin on recognition memory were also evaluated. Male CD1 mice were randomly divided into four groups: non-stressed + saline (NS+SAL); non-stressed + indomethacin (NS+IND); stressed + saline (S+SAL); and stressed + indomethacin (S+IND). Stressed animals were exposed to a daily 10 min agonistic confrontation (CSDS) for 20 days. All subjects were treated daily with saline or indomethacin (10 mg/kg, i.p.). 24 h after the CSDS period, all the mice were evaluated in a social interaction test to distinguish between those that were resilient or susceptible to social stress. All subjects (n = 10–12 per group) were then evaluated in inhibitory avoidance (IA), novel object recognition (NOR), elevated plus maze and hot plate tests. As in control animals (NS+SAL group), IA learning was observed in the resilient groups, as well as in the susceptible mice treated with indomethacin (S+IND group). Recognition memory was observed in the non-stressed and the resilient mice, but not in the susceptible animals. Also, stressed mice exhibited higher anxiety levels. No significant differences were observed in locomotor activity or analgesia. In conclusion, CSDS induces anxiety in post-pubertal mice and impairs emotional and recognition memory in the susceptible subjects. The effects of CSDS on emotional memory, but not on recognition memory and anxiety, are reversed by indomethacin. Moreover, memory impairment is not secondary to the effects of CSDS on locomotor activity, emotionality or pain sensitivity.

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Section: Discussionmentioning

confidence: 99%

Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice

2017

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“…However, in addition, our data point out that EE counteracts the adverse effects of poor environment and social isolation on cortical thickness, it also showed that EE also neutralises the unconditioned and anxiogenic effects of alcohol withdrawal. It is important to note that chronic stress by itself profoundly affects the dendritic morphology of PrL neurons (Negron‐Oyarzo et al, 2014). Similar data were found regarding the IL.…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment may protect against neural and behavioural damage caused by withdrawal from chronic alcohol intake

Nobre

2016

Intl J of Devlp Neuroscience

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Exposure to stress and prolonged exposure to alcohol leads to neuronal damages in several brain regions, being the medial prefrontal cortex (mPFC) one of the most affected. These changes presumably reduce the ability of the organism to cope with these stimuli and may underlie a series of maladaptive behaviours among which include drug addiction and withdrawal. Drug-addicted individuals show a pattern of behavior similar to patients with lesions of the mPFC. This impairment in the decision-making could be one of the mechanisms responsible for the transition from the casual to compulsive drug use. The environmental enrichment (EE) has a protective effect on the neural and cognitive impairments induced by psychoactive drugs, including ethyl alcohol. The present study aims to determine the influence of withdrawal from intermittent long-term alcohol exposure on alcohol preference, emotional reactivity and neural aspects of early isolated or grouped reared rats kept under standard or complex environments and the influence of social isolation on these measures, as well. Our results point out new insights on this matter showing that the EE can attenuate the adverse effects of withdrawal and social isolation on rat's behavior. This effect is probably due to its protective action on the mPFC integrity, including the cingulate area 1 (Cg1), and the prelimbic (PrL) and infralimbic cortex (IL), what could account for the absence of changes in the emotional reactivity in EE alcohol withdrawal rats. We argue that morphological changes at these cortical levels can afford the emotional, cognitive and behavioural dysregulations verified following withdrawal from chronic alcohol intake.

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“…Stress and anxiety are behaviorally as well as biologically linked in both humans and rodents [35,36]. In mice, anxiety-like behaviors can be assessed by examining behavioral change in the open field test, the social interaction test, and the marble-burying test [20–25,37–40].…”

Section: Discussionmentioning

confidence: 99%

Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice

Burgado

Harrell

Eacret

et al. 2014

Behavioural Brain Research

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Psychological stress can have devastating and lasting effects on a variety of behaviors, especially those associated with mental illnesses such as anxiety and depression. Animal models of chronic stress are frequently used to elucidate the mechanisms underlying the relationship between stress and mental health disorders and to develop improved treatment options. The current study expands upon a novel chronic stress paradigm for mice: predatory stress. The predatory stress model incorporates the natural predator-prey relationship that exists among rats and mice and allows for greater interaction between the animals, in turn increasing the extent of the stressful experience. In this study, we evaluated the behavioral effects of exposure to 15 days of predatory stress on an array of behavioral indices. Up to 2 weeks after the end of stress, adult male mice showed an increase of anxiety-like behaviors as measured by the open field and social interaction tests. Animals also expressed an increase in depressive-like behavior in the sucrose preference test. Notably, performance on the novel object recognition task, a memory test, improved after predatory stress. Taken as a whole, our results indicate that 15 exposures to this innovative predatory stress paradigm are sufficient to elicit robust anxiety-like behaviors with evidence of co-morbid depressive-like behavior, as well as changes in cognitive behavior in male mice.

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Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex

Cited by 45 publications

References 65 publications

Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice

Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice

Environmental enrichment may protect against neural and behavioural damage caused by withdrawal from chronic alcohol intake

Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice

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