“…In this context, it should be noted that recently, different hypothetical phenotypes of OA were suggested, each with their respective key drivers of the disease. 42 Two of these drivers (ie, mechanotransduction and metabolic drivers) can both be linked to body weight. Mechanotransduction has been interpreted as a ''mechanical load that may drive a wear and tear effect,'' and the metabolic driver was interpreted as ''unhealthy phenotypes, such as obesity, that may drive OA through adipokines.''…”