Fluorescence in situ hybridization panel for monitoring of minimal residual disease in patients with double minute chromosomes

Jeon, Yongbum; Kim, Seon‐Young; Kim, Miyoung; Park, Hyun Kyung; Lee, Sang Ho; See, Cha Ja; Kwon, Jiseok; Lee, Dong Hoon

doi:10.1016/j.bcmd.2013.10.008

Cited by 1 publication

(1 citation statement)

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“…For a long time, fluorescence in situ hybridization (FISH)-based approaches have been used to resolve amplified oncogenes linked with cancer development. However, FISH probes have been unable to discriminate the location of specific genes on chromosomal and extrachromosomal DNA molecules [ 157 ]. A more advanced cell-imaging technology, ecSeg [ 158 ], has been introduced to accurately quantify oncogene amplification from ecDNA at the single-cell level.…”

Section: Introductionmentioning

confidence: 99%

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

et al. 2020

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Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal DNA is a frequent event that drives intratumoral genetic heterogeneity and provides a potential evolutionary advantage. This review highlights the current understanding of the extrachromosomal circular DNA present in the tissues and circulation of patients with advanced cancers and provides a detailed discussion of their substantial roles in tumor regulation. Confirming the presence of cancer-related extrachromosomal circular DNA would provide a putative testing strategy for the precision diagnosis and treatment of human malignancies in clinical practice.

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Section: Introductionmentioning

confidence: 99%