Effects of Cadmium on Bone Mineral Density in the Distal and Proximal Forearm: Two Female Population Studies in China

Xiao, Changfa; Zhu, Guoying; Jin, Taiyi; Wang, Zhongqiu

doi:10.1007/s12011-013-9838-x

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…Previous studies on Cd have focused on chronic low Cd exposure, mainly from dietary sources, which damages organ function and human health, rather than acute, lethal exposure 35 . Among these reports, studies have emerged that demonstrate the toxic influence of chronic low Cd exposure on bone mineral density 36 37 38 39 . One potential molecular mechanism of Cd-induced bone toxicity is osteoblast apoptosis, which is responsible for bone remodeling 40 .…”

Section: Discussionmentioning

confidence: 99%

Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts

Liu

Dai

Wang

et al. 2016

Sci Rep

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Cadmium (Cd) is a common environmental pollutant that can damage many organs and the fetus. We previously reported that Cd induced apoptosis in primary rat osteoblasts (OBs). OB apoptosis induced by Cd will eventually lead to osteoporosis. In this study, a novel pharmacotherapeutic approach was investigated involving the regulation of autophagy to prevent Cd osteoporosis. The results showed that Cd treatment induced apoptosis in OBs, as demonstrated by the ratio of Bax/Bcl-2, activation of poly (ADP-ribose) polymerase (PARP) and nuclear condensation. In addition, cells treated with Cd were observed to undergo autophagic cell death by monitoring the induction of the beclin 1, autophagy gene 5 (Atg5) and the expression of microtubule-associated protein 1 light chain 3 (LC3). The results indicated that promotion of apoptotic cell death by Cd is accompanied by induction of autophagy in OBs. Interestingly, Cd-mediated apoptotic cell death was suppressed by pretreatment with the autophagy activator rapamycin (RAP) and potentiated by the autophagy inhibitor chloroquine (CQ) or small interfering RNA against beclin 1. These findings suggest that the autophagic response plays a protective role that impedes eventual cell death. Activation of autophagy could therefore be an adjunctive strategy for treatment of Cd-induced osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts

Liu

Dai

Wang

et al. 2016

Sci Rep

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“…70 Bone mineral density was also shown to be affected in Chinese women following Cd exposure which also correlated with renal symptoms. 71 However, low-level Cd exposure may affect kidney tubules without the involvement of glomeruli and impairment of the bones. 72 It is now apparent from the data accumulated from many studies that early monitoring of at-risk populations would be very beneficial.…”

Section: Heavy Metalsmentioning

confidence: 99%

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

2022

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Environmental and occupational exposure to heavy metals and metalloids is a major global health risk. The kidney is often a site of early damage. Nephrotoxicity is both a major consequence of heavy metal exposure and potentially an early warning of greater damage. A paradigm shift occurred at the beginning of the 21st century in the field of renal medicine. The medical model of kidney failure and treatment began to give way to a social model of risk factors and prevention with important implications for environmental health. This development threw into focus the need for better biomarkers: markers of exposure to known nephrotoxins; markers of early damage for diagnosis and prevention; markers of disease development for intervention and choice of therapy. Constituents of electronic waste, e-waste or e-pollution, such as cadmium (Cd), lead (Pb), mercury (HG), arsenic (As) and silica (SiO2) are all potential nephrotoxins; they target the renal proximal tubules through distinct pathways. Different nephrotoxic biomarkers offer the possibility of identifying exposure to individual pollutants. In this review, a selection of prominent urinary markers of tubule damage is considered as potential tools for identifying environmental exposure to some key metallic pollutants.

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“…Additional data inspection and conversion were performed to unify the database. Due to data overlap in serial articles by Chen et al [36][37][38][39][40], only the one most relevant to this study was included [39]. The authors of three original studies [18,23,39] kindly provided additional unpublished data.…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between Environmental Cadmium Exposure and Osteoporosis Risk in Postmenopausal Women: A Systematic Review and Meta-Analysis

Kunioka

Manso

Carvalho

2022

IJERPH

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Osteoporosis is a common and serious health issue among postmenopausal women. We conducted a systematic review and meta-analysis study to determine whether environmental exposure to cadmium (Cd) is a risk factor for postmenopausal osteoporosis. A PROSPERO-registered review of the literature was performed on studies evaluating the relationship between urinary Cd (UCd) concentration, an indicator of long-term Cd exposure, and bone mineral density or osteoporosis in women aged 50 years and older. PubMed, Embase, Science Direct, Web of Science, and B-on databases were searched for articles published between 2008 and 2021. The association between UCd levels and osteoporosis risk was assessed by pooled odds ratio (OR) and 95% confidence interval (CI) using random-effect models. Ten cross-sectional studies were included in the qualitative analysis, of which five were used for meta-analysis. We separately assessed the risk of osteoporosis in women exposed to Cd at low environmental levels (n = 5895; UCd ≥ 0.5 μg/g creatinine versus UCd < 0.5 μg/g creatinine) and high environmental levels (n = 1864; UCd ≥ 5 μg/g creatinine versus UCd < 5 μg/g creatinine). The pooled OR for postmenopausal osteoporosis was 1.95 (95% CI: 1.39–2.73, p < 0.001) in the low exposure level group and 1.99 (95% CI: 1.04–3.82, p = 0.040) in the high exposure level group. This study indicates that environmental Cd exposure, even at low levels, may be a risk factor for osteoporosis in postmenopausal women. Further research based on prospective studies is needed to validate these findings.

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Effects of Cadmium on Bone Mineral Density in the Distal and Proximal Forearm: Two Female Population Studies in China

Cited by 10 publications

References 15 publications

Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts

Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

Association between Environmental Cadmium Exposure and Osteoporosis Risk in Postmenopausal Women: A Systematic Review and Meta-Analysis

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