Familial syndromes associated with intracranial tumours: a review

Ranger, Adrianna; Patel, Yatri K.; Chaudhary, Navjot; Anantha, Ram Venkatesh

doi:10.1007/s00381-013-2309-z

Cited by 26 publications

(7 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to its low incidence it is difficult to assess the role of environmental and genetic factors, and also the possible interactions among them. Some hereditary syndromes increase the risk of these tumors, such as such as neurofibromatosis, Li-Fraumeni syndrome, tuberous sclerosis, Von Hippel-Lindau syndrome or retinoblastoma 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain)

Ruano-Raviña

Aragonés

Kelsey

et al. 2017

Sci Rep

View full text Add to dashboard Cite

We aimed to know if radon concentration is associated with municipal mortality due to brain cancer in Galicia, Spain. We designed an ecological study taking as study unit Galician municipalities. To be included, municipalities had to have at least three radon measurements. We correlated radon concentrations with municipal mortality due to these malignant tumors during the period 1999–2008. We calculated the relative risk of dying of brain cancers for each municipality and correlated this value with municipal radon concentration using Spearman’s Rho. 251 municipalities were included, with close to 3,500 radon measurements and an average of 14 radon measurements at each municipality. We observed a significant correlation between residential radon with brain cancer mortality for males and females and the intensity of the correlation was higher for females. These results were reinforced when the analysis was restricted to municipalities with more than 5 radon measurements: Spearman’s Rho 0.286 (p-value < 0.001) and Spearman’s Rho 0.509 (p-value < 0.001) for males and females, respectively. These results suggest an association between residential radon and brain cancer mortality. More research using more robust epidemiological designs is needed to confirm these findings.

show abstract

Section: Introductionmentioning

confidence: 99%

Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain)

Ruano-Raviña

Aragonés

Kelsey

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Trainees should be familiar with hereditary disorders that predispose to central nervous system tumors. 5 -8 These can be accomplished at all types of training programs by incorporating a didactic lecture series as well as expanding the residents’ clinical experiences by providing increased exposure to this patient population.…”

Section: Proposed Approaches To Incorporate Training In Neuro-oncologmentioning

confidence: 99%

Neuro-Oncology Training for the Child Neurology Resident

et al. 2020

View full text Add to dashboard Cite

Neuro-oncology is a rapidly evolving subspecialty that involves the management of patients with primary or metastatic central and peripheral nervous system neoplasms, as well as any other disorders or complications affecting the nervous system that result either directly or indirectly from central nervous system or systemic malignancies and related treatment. Neurologists serve a critical role in the multidisciplinary management of these complex patients. As leaders of the Child Neurology Society Special Interest Group in NeuroOncology, we propose ways to provide sufficient exposure, minimize knowledge gaps, and optimize training experiences in neuro-oncology for child neurology residency programs.

show abstract

“…As highlighted above, associations have also been established between gliomas and several rare inheritable syndromes, such as Phakomatoses (neurocutaneous syndromes), Li-Fraumeni, enchondromatosis, and familial polyposis syndromes, which account for <5% of all gliomas ( 16 ). Variability in glioma incidence was noted between different ethnic origins, with Caucasian individuals being at higher risk of developing a malignant CNS tumor compared to African-Americans, Asian and Asian/Pacific Islanders ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations

Alakel

Ghazawi

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundGliomas account for over two-thirds of all malignant brain tumors and have few established risk factors beyond family history and exposure to ionizing radiation. Importantly, recent studies highlighted the exposure to ultrafine particles (UFP) as a putative risk factor for malignant brain tumors.MethodsClinical and geographic data encompassing all provinces and territories from 1992 to 2010 was obtained from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Linear regression and joinpoint analyses were performed to assess incidence trends. Significantly higher and lower incidence postal codes were then interrogated using Standard Industrial Classification codes to detect significant industrial activity.ResultsIn Canada, between 1992 and 2010, there were ~32,360 cases of glioma. Of these, 17,115 (52.9%) were glioblastoma. The overall crude incidence rates of 5.45 and 2.87 cases per 100,000 individuals per year for gliomas and glioblastomas, respectively, were identified. Our findings further revealed increasing crude incidence of gliomas/glioblastomas over time. A male predominance was observed. Provinces leading in glioma incidence included Quebec, Nova Scotia, and New Brunswick. Significantly lower crude incidence of glioma was found in Nunavut, Northwest Territories, Ontario, and Alberta. A putative regional clustering of gliomas was observed, with higher incidence rates in postal code areas correlating with industrial activity related to airport operations.ConclusionThis study describes the geographic distribution of the glioma disease burden and, potentially, identifies industrial activity related to airport operations as potentially being associated with higher incidence of this cancer.

show abstract

Familial syndromes associated with intracranial tumours: a review

Abstract: This review examines syndromes that are strongly associated with CNS cancers: the phakomatosis syndromes, familial syndromes such as Li-Fraumeni and familial polyposis syndromes and dyschondroplasia.

Cited by 26 publications

References 154 publications

Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain)

Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain)

Neuro-Oncology Training for the Child Neurology Resident

Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations

Contact Info

Product

Resources

About