Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part I: influence of process parameters on their preparation studied by experimental design

Abstract

To develop self-assembled liquid crystalline nanoparticles as a drug delivery system for keratoconus treatment, a formulation containing riboflavin a water-soluble drug, two surfactants (poloxamer 407 and mono acyl glycerol - monoolein-) and water was optimized and prepared by emulsification and a homogenization process. A fractional factorial design was applied to estimate the main effects and interaction effects of five parameters on two responses, namely particle size and encapsulation efficiency. The five parameters are the temperature of the two phases, the duration of emulsification, the presence of heating during homogenization, the number of passes and pressure. The most influent parameters are the presence of heating during the homogenization and the pressure that led to the production of nanoparticles with an average size of 145 nm and an average encapsulation efficiency of 46%.

Ex vivo and In vivo Evaluation of Chitosan Coated Nanostructured Lipid Carriers for Ocular Delivery of Acyclovir

“…Despite the versatility of nanoparticulate drug delivery systems coated with chitosan, only those with an optimal release rate are suitable for ophthalmic use since carrier contact time with the absorption site (corneal epithelium) is short and limited [17]. The emergence of newer preparation techniques such as selfassembly methods for lipid nanoparticle preparation, which for instance requires low energy consumption and is suitable for industrial applications, make lipid nanoparticles a potential and commercially viable drug delivery platform [18][19][20]. The aim of this study was to coat ACV loaded NLCs with chitosan in order to obtain sustained drug release, increase the corneal residence time and enhance the corneal permeability of ACV.…”

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

“…At present, LLC are among the most promising strategies for increasing a drug’s bioavailability, and for modifying release and absorption kinetics [ 28 , 100 , 101 , 102 ], as well as for target-specific drug delivery systems [ 69 , 103 ]. LLC particles are nanostructures proven to be extremely versatile for DDS, are nontoxic and biodegradable, and can be used for various routes of administration including ophthalmic [ 104 ], nasal [ 105 ], vaginal [ 106 ], dermal [ 107 ], oral [ 108 ], or parenteral [ 101 ].…”

“…In this case, the release of salt (lidocaine HCl) is slow, owing to the inability of the salt to penetrate more of the lipophilic fraction [ 119 ]. The various options described for the host drugs of microstructure LLC systems can be applied for analgesia, topical, ocular, post herpetic, and other applications [ 104 , 105 , 106 ].…”

Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System

“…Use this program to help optimize process, achieve optimal performance, discover the optimal formulation, combine process variables, mixture components and categorical factors in one design. The two parameters that studied (concentration and time) and the response was insert as group and decide the optimal parameter theoretical and experimental and studied the more effect parameter [15].…”