Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI

Takeuchi, Mayumi; Matsuzaki, Kei; Uehara, Hisanori; Furumoto, Hiroyuki; Harada, Masafumi

doi:10.2463/mrms.2013-0001

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The carcinogenesis model, by which benign CCAF progresses in multiple stages from borderline to malignant CCAF, then CCC, through the accumulation of genetic abnormalities, has also been suggested . CCAF was previously reported to develop into CCC in a process detected as decreased diffusion on diffusion‐weighted MRI . Moreover, malignant tumors do not have high signal intensity on diffusion‐weighted imaging because of their cell density.…”

Section: Discussionmentioning

confidence: 99%

Mature cystic teratoma coexisting with clear‐cell carcinoma in the ovary

Shimura

Matsumoto

Sugahara

et al. 2016

J of Obstet and Gynaecol

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Mature cystic teratoma (MCT) is the most common benign ovarian tumor; clear-cell carcinoma (CCC) is a relatively common malignant ovarian tumor in Japan, but there are few reports on the coexistence of MCT and CCC. Here we report a case of simultaneous MCT and CCC in the ovary and review the relevant literature. The patient was a 49-year-old woman. A 5-cm MCT was found in the left ovary on initial gynecological examination, and she was referred to hospital for treatment because it was expanding. Magnetic resonance imaging showed a multilocular cystic tumor 16 × 10 × 9.5 cm in the left ovary, and surgery was performed. The final pathological diagnosis was MCT, endometriotic cyst, clear-cell adenofibroma, clear-cell borderline tumor, and CCC in the left ovary.

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Section: Discussionmentioning

confidence: 99%

Mature cystic teratoma coexisting with clear‐cell carcinoma in the ovary

Shimura

Matsumoto

Sugahara

et al. 2016

J of Obstet and Gynaecol

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“…Administration of a contrast agent (CA) enables differentiation of enhancement patterns of tumors from those of normal tissues. [1][2][3][4][5] Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA; Magnevist, Schering, Berlin, Germany) is the first CA approved by the U.S. Food and Drug Administration (FDA) since 1988 as a nonspecific extracellular CA and has been widely used in DCE-MRI. 6,7 Since then, several novel CAs have also been approved for clinical use.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Flip Angle and TR on the Enhancement Ratio of Dynamic Gadobutrol-enhanced MR Imaging: <i>In Vivo</i> VX2 Tumor Model and Computer Simulation

et al. 2015

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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to diagnose cancer and monitor therapy. The maximum enhancement ratio (ER max ) obtained from the curve of signal intensity over time could be a biomarker to distinguish cancer from normal tissue or benign tumors. We evaluated the impact of flip angle (FA) and repetition time (TR) on the ER max values of dynamic gadobutrol-enhanced MR imaging, obtaining T 1 -weighted (T 1 W) MR imaging of VX2 tumors using 2-dimensional fast spoiled gradient echo (2D FSPGR) with various FAs (30°, 60°and 90°) at 1.5 tesla before and after injection of 0.1 mmol/kg gadobutrol. In vivo study indicated significant differences between ER max values and area under the ER-time curve (AUC 100 ) of VX2 tumors and muscle tissue, with the highest ER max and AUC 100 at FA 90°. Computer simulation also demonstrated the ER as a strictly increasing monotonic function in the closed interval [0°, 90°] for a given TR when using T 1 W FSPGR, and the highest ER value always occurred at FA 90°. The FA for the highest ER differed from that for the highest signal-to-noise or contrast-to-noise ratio. For long TR, the ER value increases gradually. However, for short TR, the ER value increases rapidly and plateaus so that the ER value changes little beyond a certain FA value. Therefore, we suggest use of a higher FA, near 90°, to obtain a higher ER max for long TR in 2D SPGR or FSPGR and a smaller FA, much less than 90°, to reach an appropriate ER max for short TR in 3D SPGR or FSPGR. This information could be helpful in setting the optimal parameters for DCE-MRI.

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