Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma

Park, Seo Young; Han, Jiyou; Kim, Jong Bin; Yang, Man; Kim, Yoon Jun; Lim, Hyejin; An, Su Yeon; Kim, Jong Hoon

doi:10.1016/j.ejca.2013.09.021

Cited by 37 publications

(34 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We revealed that ccRCC cultures treated with CXCR1 blocking agents (anti-CXCR1 antibody and repertaxin) exhibited reduced proliferation, migration and invasion, sphere formation and self-renewal properties, whereas IL-8 stimulation enhanced CSC properties. This is in line with previous studies in HCC, breast and pancreatic cancers where anti-IL-8/CXCR1 impaired CSC features [34,35,41]. Moreover, flow cytometry analysis revealed that repertaxin treatment significantly decreased the SP and CXCR1 + cells in the spheres as well in the parental samples.…”

Section: Discussionsupporting

confidence: 91%

IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer

Corrò

Healy

Engler

et al. 2019

The Journal of Pathology

View full text Add to dashboard Cite

Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of cancer stem cells (CSCs) that might contribute to tumor heterogeneity, metastasis and therapeutic resistance. Nevertheless, their relevance for renal cancer is still unclear. In this study, we successfully isolated CSCs from established human ccRCC cell lines. CSCs displayed high expression of the chemokine IL‐8 and its receptor CXCR1. While recombinant IL‐8 significantly increased CSC number and properties in vitro , CXCR1 inhibition using an anti‐CXCR1 antibody or repertaxin significantly reduced these features. After injection into immune‐deficient mice, CSCs formed primary tumors that metastasized to the lung and liver. All xenografted tumors in mice expressed high levels of IL‐8 and CXCR1. Furthermore, IL‐8/CXCR1 expression significantly correlated with decreased overall survival in ccRCC patients. These results suggest that the IL‐8/CXCR1 phenotype is associated with CSC‐like properties in renal cancer. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

show abstract

Section: Discussionsupporting

confidence: 91%

IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer

Corrò

Healy

Engler

et al. 2019

The Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…It has been reported that IL-8 mediates drug resistance against certain anticancer agents [26, 27]. We hypothesized that IL-8 may also be responsible for the observed doxorubicin resistance in MDA-MB-231 cells.…”

Section: Resultsmentioning

confidence: 93%

“…The secreted cytokine cocktail includes SDF-1, IL-1 β , IL-3, IL-6, IL-8, TNF- α , NO, G-CSF, M-CSF, GM-CSF, and many others, and by various signaling pathways to protect cancer cells against chemotherapy [9]. Numerous in vitro and in vivo studies reported that cytokines are capable of modulating the expression and function of different drug transporters including P-gp, MRPs, and BCRP [26, 32, 33]. Among various types of cytokines in the tumor microenvironment, IL-8 is one of the major cytokines produced by cancer cells and stroma cells.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cell-Induced Doxorubicin Resistance in Triple Negative Breast Cancer

Chen

Lin

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Triple negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and a worse clinical outcome compared with other breast cancer subtypes. Doxorubicin is considered to be one of the most effective agents in the treatment of TNBC. Unfortunately, resistance to this agent is common. In some drug-resistant cells, drug efflux is mediated by adenosine triphosphate-dependent membrane transporter termed adenosine triphosphate-binding cassette (ABC) transporter, which can drive the substrates across membranes against concentration gradient. In the tumor microenvironment, upon interaction with mesenchymal stem cells (MSCs), tumor cells exhibit altered biological functions of certain gene clusters, hence increasing stemness of tumor cells, migration ability, angiogenesis, and drug resistance. In our present study, we investigated the mechanism of TNBC drug resistance induced by adipose-derived MSCs. Upon exposure of TNBC to MSC-secreted conditioned medium (CM), noticeable drug resistance against doxorubicin with markedly increased BCRP protein expression was observed. Intracellular doxorubicin accumulation of TNBC was also decreased by MSC-secreted CM. Furthermore, we found that doxorubicin resistance of TNBC was mediated by IL-8 presented in the MSC-secreted CM. These findings may enrich the list of potential targets for overcoming drug resistance induced by MSCs in TNBC patients.

show abstract

“…However, it has been reported that increases in the number of Th17 cells in HCC patients, which occur concurrently with increases in serum IL-17 levels, are associated with decreases in overall survival and disease-free survival time (28,29). Additionally, Park et al (30) reported that anticancer drugs can induce IL-8 secretion and the expression of IL-8 receptors on liver cells. Furthermore, serum IL-8 levels were positively correlated with tumor size, whereas silencing of the IL-8 gene within hepatocytes significantly decreased tumor size.…”

Section: Discussionmentioning

confidence: 99%

Involvement of soluble B7‑H3 in combination with the serum inflammatory cytokines interleukin‑17, ‑8 and ‑6 in the diagnosis of hepatocellular carcinoma

Wang

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Previous studies have demonstrated that B7-H3, and the inflammatory cytokines interleukin (IL)-17, IL-8 and IL-6, are involved in the development of a variety of tumors. The objectives of the present study were: i) To investigate the association between soluble B7-H3 (sB7-H3) and cytokine levels of IL-17, IL-8 and IL-6 in the serum of patients with hepatocellular carcinoma (HCC); and ii) to determine their potential value for use in HCC diagnosis. Serum sB7-H3, IL-17, IL-8 and IL-6 levels in the HCC patients and healthy control subjects were measured using ELISA. The accuracy of each of these biomarkers in HCC diagnosis was compared using a receiver operating characteristic curve and the area under the curve (AUC). A logistic regression model was used to investigate the accuracy of diagnosing HCC when evaluated using combined determinations of sB7-H3, IL-17, IL-8 and IL-6 levels. The data demonstrated that serum levels of sB7-H3, IL-17, IL-8 and IL-6 were significantly increased in HCC patients compared with those in the healthy control group. Serum sB7-H3 levels were positively associated with serum IL-17, whereas serum IL-8 levels were negatively correlated with serum IL-17 levels. The AUC values for sB7-H3, IL-17, IL-8 and IL-6 were 83.2, 65.7, 95.3 and 97.0%, respectively, and indicated that all four biomarkers exhibited a statistically significant capacity for diagnosing HCC. Using the logistic regression model, the AUC value, sensitivity and specificity, as determined for the combination of the four biomarkers, were 99.2, 96.67 and 97.14%, respectively. This was significantly greater than that achieved when any single biomarker was used alone in the logistic regression model to assess their accuracy in HCC diagnosis. The optimum cutoff value of the predicted probability obtained by the combination of sB7-H3, IL-17, IL-8 and IL-6 in the regression model was 0.5745. To conclude, the present study revealed that there exists a positive association between serum sB7-H3 and IL-17 levels in HCC patients. Determinations involving the combination of serum sB7-H3, IL-17, IL-8 and IL-6 levels demonstrate great potential for use in HCC diagnosis.

show abstract

Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma

Cited by 37 publications

References 28 publications

IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer

IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer

Mesenchymal Stem Cell-Induced Doxorubicin Resistance in Triple Negative Breast Cancer

Involvement of soluble B7‑H3 in combination with the serum inflammatory cytokines interleukin‑17, ‑8 and ‑6 in the diagnosis of hepatocellular carcinoma

Contact Info

Product

Resources

About