Safety of Cidofovir by Intratympanic Delivery Technique

Ward, Jonette A.; Sidell, Douglas; Nassar, Michel; Reece, Alisa; Choo, Daniel I.

doi:10.3851/imp2693

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Due to the tympanic membrane barrier, OM treatment typically requires systemic administration of antibiotics [8]. Recently, therapeutics have been successfully administered to the middle ear through intratympanic injection or perfusion [9,10]. Outer ear infections, also known as otitis externa (OE), or Swimmer’s Ear, can affect a larger demographic that includes children, adolescents, and adults [11].…”

Section: Introductionmentioning

confidence: 99%

A Controlled Antibiotic Release System for the Development of Single-Application Otitis Externa Therapeutics

Șerban

Stipe

Alverson

et al. 2017

Gels

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Ear infections are a commonly-occurring problem that can affect people of all ages. Treatment of these pathologies usually includes the administration of topical or systemic antibiotics, depending on the location of the infection. In this context, we sought to address the feasibility of a single-application slow-releasing therapeutic formulation of an antibiotic for the treatment of otitis externa. Thixotropic hydrogels, which are gels under static conditions but liquefy when shaken, were tested for their ability to act as drug controlled release systems and inhibit Pseudomonas aeruginosa and Staphylococcus aureus, the predominant bacterial strains associated with outer ear infections. Our overall proof of concept, including in vitro evaluations reflective of therapeutic ease of administration, formulation stability, cytocompatibility assessment, antibacterial efficacy, and formulation lifespan, indicate that these thixotropic materials have strong potential for development as otic treatment products.

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