BLT Humanized Mice as Model to Study HIV Vaginal Transmission

Déruaz, Maud; Luster, Andrew D.

doi:10.1093/infdis/jit318

Cited by 28 publications

(24 citation statements)

References 48 publications

(69 reference statements)

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“…These data demonstrated in vivo that elite control of HIV is unlikely to be mediated purely by defective virus [36]. Additionally, the susceptibility of the BLT mouse to both vaginal and rectal challenge with HIV [8,32,37-40] has facilitated the study of the dynamics of mucosal transmission and early viral dissemination [9]. Similarly, the capacity of the model to support live, in vivo multiphoton intravital microscopy during HIV infection revealed that cell-to-cell virus spread may be enhanced by the ability of HIV to impair T cell motility in lymph nodes [41,42].…”

Section: Applications Of Humanized Mice To Hiv Researchmentioning

confidence: 99%

BLT humanized mice as a small animal model of HIV infection

Karpel

Boutwell

Allen

2015

Current Opinion in Virology

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Humanized mice are valuable models for the research and development of vaccine strategies and therapeutic interventions to control or eradicate HIV. The BLT humanized mouse model is particularly promising because the combination of transplantation of human fetal pluripotent hematopoietic stem cells with surgical engraftment of human fetal thymic tissue results in improved T cell reconstitution, maturation, and selection. To date, the BLT humanized mouse model has been used to study many aspects of HIV infection including prevention, mucosal transmission, HIV-specific innate and adaptive immunity, viral latency, and novel antiretroviral and immune-based therapies for suppression and reservoir eradication. Here we describe recent advances and applications of the BLT humanized mouse model of HIV infection and discuss opportunities to further improve this valuable small animal model.

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Section: Applications Of Humanized Mice To Hiv Researchmentioning

confidence: 99%

BLT humanized mice as a small animal model of HIV infection

Karpel

Boutwell

Allen

2015

Current Opinion in Virology

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show abstract

“…Improved humanized mouse models now permit investigations on the potential efficacy of HIV-specific cellular and humoral immune responses, and the preclinical modeling of novel anti-HIV therapeutic and prevention agents (Chateau et al, 2013;Deruaz and Luster, 2013;Tager et al, 2013;West et al, 2014). These models permit analysis of trafficking of human immune cells following mucosal HIV transmission and where HIV-1 persists in tissues.…”

Section: Humanized Micementioning

confidence: 99%

Mucosal Immunity and Vaccines Against Simian Immunodeficiency Virus and Human Immunodeficiency Virus

McElrath

2015

Mucosal Immunology

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“…Despite this, current models used for studying sexual transmission of HIV-1 might not really imitate human HIV-1 transmission since animals are directly challenged with a concentrated virus stock to vaginal or rectal surfaces in the absence of semen [32,33,75]. More recently, sexual transmission of HIV-1 by coitus has been described in a new mouse model [54].…”

Section: Semen Diminishes the Antiviral Activity Of Microbicides And mentioning

confidence: 99%