Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats

Lima, Márcia; Malheiros, Jackeline Moraes; Negrigo, Aline; Tescarollo, Fabio; Medeiros, Magda Alves de; Suchecki, Deborah; Tannús, Alberto; Guinsburg, Ruth; Covolan, Luciene

doi:10.1016/j.neuropharm.2013.10.007

Cited by 28 publications

(22 citation statements)

References 65 publications

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“…In rodent brain, profound differences have been reported between males and females in response to early life stress, particularly on neurogenesis (Oomen et al, 2009; Negrigo et al, 2011; Korosi et al, 2012; Lima et al, 2014). In the current study, we showed that gender does not interfere in the dentate gyrus neurogenesis rate (Marlatt et al, 2011), and thus we have chosen to pool male and female animals.…”

Section: Discussionmentioning

confidence: 99%

Social isolation disrupts hippocampal neurogenesis in young non-human primates

et al. 2014

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Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. In agreement, grooming—an indicative of attenuation of tension—was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.

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Section: Discussionmentioning

confidence: 99%

Social isolation disrupts hippocampal neurogenesis in young non-human primates

et al. 2014

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“…It has been recently demonstrated that early neonatal stimulation in rats promotes long-term alterations in the behavioral repertoire (Negrigo, Medeiros et al 2011), as well as in the dentate neurogenesis rate (Leslie, Akers et al 2011;Lima, Malheiros et al 2014;Malheiros, Lima et al 2014). Although some research report increased neurogenesis induced by hypoxia-ischemia in adult rodents (Kadam, Mulholland et al 2009;Zhu, Qiu et al 2009), studies on the effects of neonatal hypoxia in the proliferation and neurogenesis using this model of neonatal anoxic insult in rats remain primary unknown.…”

Section: Introductionmentioning

confidence: 99%

Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

Takada

Motta-Teixeira

Machado-Nils

et al. 2016

Behavioural Brain Research

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“…All the data on the issues addressed in the present paper were traditionally obtained on males. In a few recent studies conducted on rat males and females [4,15,27,28], the question has been raised about sex differences in the effect of neonatal pain on the nociceptive system functional activity in further ontogenesis. To account for possible mechanisms of sexual dimorphism, it is necessary to consider developmental peculiarities of the neuroendocrine and nociceptive systems during the effect of adverse factors in the neonatal period and when examining their aftereffects in older animals.…”

Section: Introductionmentioning

confidence: 99%

Differences in adaptive behaviors of adolescent male and female rats exposed at birth to inflammatory pain or stress

Butkevich

Mikhailenko

Vershinina

et al. 2015

J Evol Biochem Phys

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In adolescent rats (25-35-day-old) exposed at birth (neonatal days 1 and, repeatedly, 2) to adverse impacts (inflammatory pain, short-term maternal separation stress, or both), sexual dimorphism was found in pain behavior under identical peripheral inflammation conditions. Our priority data indicate an enhancement of pain response in the formalin test in males, whereas in females pain sensitivity did not change, i.e. pain experienced in females at birth did not affect the system reactivity to the same chemical irritant in the adolescent period. However, rats of both sexes exposed to short-term maternal deprivation stress (60 min on neonatal days 1 and 2) exhibited the enhanced pain sensitivity in the formalin test. The combined impact of inflammatory pain and maternal deprivation in neonatal pups did not change pain sensitivity at adolescence both in males and females. Male and female rats exposed to early maternal deprivation exhibited decreased anxiety levels in the elevated plus-maze; rats exposed to each of the above-mentioned early impacts showed a decline in adaptive behavior in the forced swim test; males exposed to pain and combined impacts demonstrated the spatial learning impairment in the Morris labyrinth. Thus, we have pioneered in demonstrating sex-dependent differences in the effect of inflammatory pain in neonatal rat pups on the inflammatory pain sensitivity in adolescent rats. The division of early stress and pain impacts was revealed in adolescent females in the formalin test: while maternal deprivation induced hyperalgesia, pain did not change the tonic nociceptive system functional activity.

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Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats

Cited by 28 publications

References 65 publications

Social isolation disrupts hippocampal neurogenesis in young non-human primates

Social isolation disrupts hippocampal neurogenesis in young non-human primates

Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

Differences in adaptive behaviors of adolescent male and female rats exposed at birth to inflammatory pain or stress

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