<i>Borrelia chilensis</i>, a new member of the<i>Borrelia burgdorferi</i>sensu lato complex that extends the range of this genospecies in the<scp>S</scp>outhern<scp>H</scp>emisphere

Ivanova, Larisa; Tomova, Alexandra; González‐Acuña, Daniel; Murúa, Roberto; Moreno, Cláudia; Hernández, Claudio; Cabello, Javier; Cabello, Carlos; Daniels, Thomas J.; Godfrey, Henry P.; Cabello, Felipe C.

doi:10.1111/1462-2920.12310

Cited by 107 publications

(67 citation statements)

References 85 publications

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“…There are at least 19 known genospecies of B. burgdorferi ( s.l. ) [6, 7]. In Scotland, four genospecies have been detected in questing ticks [8, 9]: B. afzelii , B. garinii , B. burgdorferi ( sensu stricto ) and B. valaisiana .…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction

et al. 2016

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BackgroundCases of Lyme borreliosis, a vector-borne zoonosis caused by bacteria in the Borrelia burgdorferi (sensu lato) species group, have increased in recent years in Europe. Knowledge of environmental factors associated with abundance of the tick vector Ixodes ricinus and the pathogen B. burgdorferi (s.l.) is of interest to understand responses to environmental changes, predict variation in risk and to inform management interventions.MethodsNineteen woodland sites across Scotland were surveyed in 2012 for B. burgdorferi (s.l.) infection in questing I. ricinus nymphs (n = 200 per site), deer abundance and vegetation. Climatic factors were extracted for each site. Six additional sites were surveyed for questing nymphs in both 2012 and 2013 (n = 200 per site and year) to test for variation in B. burgdorferi (s.l.) prevalence between years.ResultsThe mean prevalence of B. burgdorferi (s.l.) across 19 sites was 1.7% (95% CI: 1.4–2.2%; range 0–6%), all four genospecies known to be present in the UK were detected: B. garinii, B. afzelii, B. burgdorferi (sensu stricto) and B. valaisiana. A higher prevalence of B. burgdorferi (s.l.), higher densities of nymphs and higher densities of infected nymphs were found at sites with warmer climates, estimated with growing degree-days. No association between infection prevalence in nymphs and woodland type (semi-natural mixed vs coniferous) or deer density was found. At six sites sampled in 2012 and 2013, there was a significant increase in B. afzelli prevalence at two sites and a decrease in B. garinii prevalence at one site.ConclusionsThis study highlights challenges for the prediction of risk of Lyme borreliosis, reflecting the sensitivity of both pathogen and vector ecology to habitat, host and climatic factors. Significant changes in the prevalence of individual genospecies at sites monitored across time are likely to be due to variability in the host community composition between years. Our results indicate the importance of monitoring dynamic variables such as reservoir host populations as well as climate and habitat factors over multiple years, to identify environmental factors associated with Lyme borreliosis risk.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-016-1875-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction

et al. 2016

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“…This biogeography hypothesis, however, is now challenged with the discovery of a New World species from Chile “ B. chilensis” , which appears to be the most basal B. burgdorferi s.l. species known so far (Ivanova et al, 2013) (Section 7).…”

Section: Genome Sampling and Genome Phylogenymentioning

confidence: 99%

“…species is at least twenty including the eighteen that have been previously reviewed and the more recently proposed species “ B. finlandensis” and “B. chilensis” (Casjens et al, 2011a; Ivanova et al, 2013; Margos et al, 2011). From this latest catalog of species, it is clear that the New World species are under-represented in the currently available genomes.…”

Section: Genome Sampling and Genome Phylogenymentioning

confidence: 99%

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Evolutionary genomics of Borrelia burgdorferi sensu lato: Findings, hypotheses, and the rise of hybrids

Qiu

Martin

2014

Infection, Genetics and Evolution

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Borrelia burgdorferi sensu lato (B. burgdorferi s.l.), the group of bacterial species represented by Lyme Disease pathogens, has one of the most complex and variable genomic architectures among prokaryotes. Showing frequent recombination within and limited gene flow among geographic populations, the B. burgdorferi s.l. genomes provides an excellent window into the processes of bacterial evolution at both within- and between-population levels. Comparative analyses of B. burgdorferi s.l. genomes revealed a highly dynamic plasmid composition but a conservative gene repertoire. Gene duplication and loss as well as sequence variations at loci encoding surface-localized lipoproteins (e.g., the PF54 genes) are strongly associated with adaptive differences between species. There are a great many conserved intergenic spacer sequences that are candidates for cis-regulatory elements and non-coding RNAs. Recombination among coexisting strains occurs at a rate approximately three times the mutation rate. The coexistence of a large number of genomic groups within local B. burgdorferi s.l. populations may be driven by immune-mediated diversifying selection targeting major antigen loci as well as by adaptation to multiple host species. Questions remain regarding the ecological causes (e.g., climate change, host movements, or new adaptations) of the ongoing range expansion of B. burgdorferi s.l. and on the genomic variations associated with its ecological and clinical variability. Anticipating an explosive growth of the number of B. burgdorferi s.l. genomes sampled from both within and among species, we propose genome-based methods to test adaptive mechanisms and to identify molecular bases of phenotypic variations. Genome sequencing is also necessary to monitor the ongoing genetic admixture of previously isolated species and populations in North America and elsewhere.

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“…Elle sévit principalement dans l'hémisphère Nord mais son aire de répartition semble s'étendre vers le sud. Une nouvelle description récente d'espèce a été faite au Chili (Ivanova et al, 2014).…”

Section: Introductionunclassified

Borréliose de Lyme : impact de l’homme sur la persistance et la circulation de Borrelia Burgdorferi sensu lato dans l’environnement

Boulanger¹,

Jaulhac²

2015

bavf

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La borréliose de Lyme est une infection bactérienne transmise par les tiques dures du genre Ixodes. C'est avant tout une zoonose qui circule dans un large panel d'hôtes vertébrés sauvages (lézards, oiseaux, rongeurs, cervidés…) et domestiques ; l'homme est un hôte accidentel. Ces dernières années, la notion d'émergence a été évoquée pour cette pathologie, notamment à cause des modifications climatiques. Les raisons sont plus complexes. La pathologie est mieux connue sur un plan médical grâce aux progrès diagnostiques, cliniques et épidémiologiques. De plus, l'analyse des différents facteurs biotiques et abiotiques laissent penser que l'anthropisation des environnements où évoluent les tiques, est responsable de l'émergence des maladies transmises par les tiques dont la borréliose de Lyme. En effet, l'homme modifie pour des raisons socio-économiques surtout, les écosystèmes forestiers et la faune sauvage qui favorisent le développement des populations de tique et donc des maladies qu'elles transmettent. Mots

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Borrelia chilensis, a new member of theBorrelia burgdorferisensu lato complex that extends the range of this genospecies in theSouthernHemisphere

Cited by 107 publications

References 85 publications

Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction

Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction

Evolutionary genomics of Borrelia burgdorferi sensu lato: Findings, hypotheses, and the rise of hybrids

Borréliose de Lyme : impact de l’homme sur la persistance et la circulation de Borrelia Burgdorferi sensu lato dans l’environnement

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