The effect of platelet‐derived microparticles in stored apheresis platelet concentrates on polymorphonuclear leucocyte respiratory burst

Abstract

The platelet-derived microparticles, which carried the sCD40L, accumulated in the apheresis platelet concentrates during the 5 days of storage. They primed the fMLP-activated PMN respiration burst, which might be relative to TRALI.

Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside

“…[58][59][60] Soluble CD40L activates macrophages and elicits the production and release of multiple pro-inflammatory cytokines. Increased sCD40L in stored platelets has been associated with transfusion reactions [61] and increased respiratory burst in polymorphonuclear leukocytes (PMNs) [62]. In animal models, acute lung injury caused by LPS or reactive oxygen species (ROS) is attenuated by inhibition of the CD40-CD40L system [56,63].…”

Platelet‐derived microparticles induce polymorphonuclear leukocyte‐mediated damage of human pulmonary microvascular endothelial cells

“…Our recent study demonstrated that PLT‐derived microparticles (PMPs) carried concentrated CD40L signal. These microparticles effectively prime formyl‐Met‐Leu‐Phe (fMLP)‐activated PMN respiration burst . However, the effects of PMPs from PLT concentrates on endothelial cells are unknown.…”

Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury

“…In addition to RBCs, the platelet-derived MPs increase during the storage period, prime the fMLP-activated PMN respiration burst, which may induce TRALI [59]. Moreover, monocyte-derived MPs up regulate the level of pro-inflammatory factors in lung epithelial cells, primarily through activating NF-κB and PPAR-γ dependent pathways [60].…”