Suitability and Repeatability of a Photostress Recovery Test Device, the Macular Degeneration Detector (Mdd-2), for Diabetes and Diabetic Retinopathy Assessment

Loughman, James; Ratzlaff, Matthew; Foerg, Brittany; Connell, Paul

doi:10.1097/iae.0000000000000021

Cited by 7 publications

(6 citation statements)

References 37 publications

(53 reference statements)

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“…Our findings indicate that a relationship between MPOD and photostress recovery is confined to those with foveal-involved glaucoma, who demonstrated a prolonged PRT. In a study comparing healthy controls and those with diabetes mellitus (with and without diabetic retinopathy subgroups), there was no difference in PRT between groups 28. However, the study did not include those with diabetic maculopathy.…”

Section: Discussionmentioning

confidence: 99%

Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma

2017

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AimTo evaluate the relationship between macular pigment optical density (MPOD) and glare disability in open-angle glaucoma.MethodsA cross-sectional analysis of baseline data (88 subjects; median age, 67 (range 36–84) years) collected during the Macular Pigment and Glaucoma Trial (ISRCTN registry number: 56985060). MPOD at 0.25°, 0.5° and 1° of retinal eccentricity was measured using customised heterochromatic flicker photometry. Mesopic contrast sensitivity with glare (mCSg), photostress recovery time (PRT) and self-reported glare symptoms were evaluated. Fourier-domain optical coherence tomography was used to analyse ganglion cell complex (GCC) and identify foveal involvement.ResultsLow spatial frequency (f) mCSg was significantly correlated with MPOD at 0.25°(3 cycles per degree (cpd): r=0.25, p=0.04) and 0.5° (3 cpd: r=0.23, p=0.04) of retinal eccentricity. Those with foveal GCC loss exhibited lower MPOD, had worse low spatial fmCSg (1.5 cpd and 3 cpd, p=0.02 each) and prolonged PRT (p=0.02) in comparison with those without foveal involvement. The depth of central 10° field loss was related to MPOD at all eccentricities (p<0.01 for all). Those who reported glare symptoms had a significantly lower MPOD at all retinal eccentricities (0.25° and 1°: p=0.05 each; 0.5°: p=0.04), including those with foveal involvement (0.25°: p=0.05; 0.5°: p<0.01; 1°: p=0.01).ConclusionsMacular pigment level may be an important consideration among those experiencing disability glare in glaucoma, including those with foveal involvement.Trial registration numberISRCTN56985060, Post-results.

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Section: Discussionmentioning

confidence: 99%

Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma

2017

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“…Photostress recovery allows the differentiation between normal and abnormal macular function. Photostress recovery is not specific for a certain disease, but there are different clinical conditions that can affect the functioning of the macular area [ 29 ]. For instance, in some cases, macular integrity can be related to visual function, but this relationship is not univocal.…”

Section: Results: Critical Analysis Of Outcome Variables and Methomentioning

confidence: 99%

Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006

et al. 2018

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Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims. This manuscript refers to the collection, collation and critical analysis of OVs and MMs related to vision. Guidance document and requests for authorization of health claims were used to collect OVs and MMs related to vision. A literature review was performed to critically analyse OVs and MMs, with the aim of defining their appropriateness in the context of a specific claimed effect related to vision. The results highlight the importance of adequate choices of OVs and MMs for an effective substantiation of claims related to visual function.

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“…The timing of the PSRT starts when the examiner triggers the disabling source and ends when the subject presses a stop bottom once the contrast sensitivity baseline is recovered. At the end of each measurement, ve minutes are allowed for total disability glare recovery [23]. PSRT was measured for 5 glare incident angles (3º, 5º, 7º, 11º and 14º) and 5 levels of Michelson´s Contrast levels of the visual stimulus (See Fig.…”

Section: Methodsmentioning

confidence: 99%

Recovery Time from Total Disability Glare is Increased in Myopic Eyes

Ávila

Casado

Ares

2022

Preprint

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Purpose To investigate differences between myopic and emmetropic eyes in the measured recovery time after retinal photobleaching in a population of young healthy subjects. Methods A Maxwellian-illumination total disability glare instrument with controllable glare angular distribution, luminous intensity and contrast of the visual stimuli was employed to measure the recovery time after photo-stress induced vision for a 240 milliseconds exposure time in 66 myopic and 66 emmetropic eyes. The measurements were carried out for different combinations of glare angles and contrast of the visual stimuli. Results Time recovery measured in myopic eyes is significantly higher than emmetropic eyes. The measured recovery depends on both the glare angle and the contrast of the stimuli. In addition, myopic and emmetropic eyes present similar sensitivity to glare in terms of time recovery, however in glare conditions, the differences of measured recovery time drastically increase with the reduction of the contrast of the stimuli between both groups of study. Conclusions A total disability glare instrument has been employed to stablish the differences in the measured recovery time after retinal photobleaching. The versatility and simplicity of the instrument could help to explore those retinal disorders related to photopigment visual function at both central and peripheral retina.

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Suitability and Repeatability of a Photostress Recovery Test Device, the Macular Degeneration Detector (Mdd-2), for Diabetes and Diabetic Retinopathy Assessment

Cited by 7 publications

References 37 publications

Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma

Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma

Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006

Recovery Time from Total Disability Glare is Increased in Myopic Eyes

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