“…Several cases have been reported with nodal relapse in the parotids after IMRT for NPC, including two cases reported by our institution. 21 Cao et al 22 reported a series wherein 10 out of 716 patients developed parotid nodal failure after IMRT for NPC. Lin et al also reported three cases out of 296 patients treated with parotid-sparing RT for NPC.…”
“…Several cases have been reported with nodal relapse in the parotids after IMRT for NPC, including two cases reported by our institution. 21 Cao et al 22 reported a series wherein 10 out of 716 patients developed parotid nodal failure after IMRT for NPC. Lin et al also reported three cases out of 296 patients treated with parotid-sparing RT for NPC.…”
“…As such, the parotid gland area receives only low radiation doses to reduce the xerostomia and further improve the quality of life of patients with NPC . However, subsequent studies have demonstrated that overprotection of the parotid gland resulted in a few cases of PLN recurrence after treatment of NPC with IMRT , which suggested that potential or definite PLN metastasis in preliminarily diagnosed patients might be neglected in clinical practice. Hence, the potential risk of initial PLN metastasis in patients with NPC receiving IMRT has garnered attention .…”
Parotid area lymph node (PLN) metastasis in nasopharyngeal carcinoma (NPC) is rare, and its prognosis remains largely unknown. Our study aimed to investigate the prognostic value and staging categories of PLN metastasis in patients with NPC and treated with intensity‐modulated radiation therapy (IMRT), to provide a reference for clinical treatment for NPC with PLN metastasis. Records for 1616 untreated NPC patients without distant metastasis was retrospectively reviewed. All patients underwent magnetic resonance imaging (MRI) examination prior to treatment and then received IMRT as their primary treatment. Forty‐five NPC patients (2.8%) showed initial PLN metastasis on follow‐up MRI. PLN metastasis was significantly associated with the N classification and clinical stage. Univariate analysis showed that PLN metastasis had an unfavorable influence on overall survival (OS), progression‐free survival (PFS), distant metastasis‐free survival (DMFS), and regional relapse‐free survival (RRFS) in NPC patients. Using propensity score matching (PSM) to calibrate selection bias and confounding bias, it was observed that PLN metastasis remained an adverse prognostic factor for OS, PFS, DMFS, and RRFS. Furthermore, the 5‐year DMFS and RRFS curves for PLN metastasis were significantly separated from that for N2 disease but crossed that for N3 disease. Therefore, PLN metastasis was found to be an adverse prognostic factor for NPC and to be associated with the same DMFS as N3 disease. Therefore, more aggressive therapeutic strategies consistent with those for N3 disease are recommended for NPC with PLN metastasis to reduce distant metastasis.
“…In 2007, Luo et al [13] has showed 3 cases of parotid recurrence in NPC patients after IMRT. In 2013, Cao et al reported 10 cases of periparotid recurrence and the incidence of parotid recurrence was 1.4 % [14]. Periparotid recurrence may be supposed to be related to sparing parotid in IMRT.…”
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