Expression of candidate genes for residual feed intake in Angus cattle

Al-Husseini, Wijdan; Gondro, Cedric; Quinn, K.; Herd, R. M.; Gibson, John P.; Chen, Yizhou

doi:10.1111/age.12092

Cited by 33 publications

(24 citation statements)

References 21 publications

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“…Consortia have performed studies worldwide to estimate the genetic (co)variation underlying feed efficiency related-traits to develop alternative opportunities for the genetic evaluation of feed efficiency. As a result, potential biomarkers from gene expression studies, conducted in beef cattle divergent for Residual Feed Intake (RFI), have now been proposed910. The relationship between growth rate and gross feed efficiency has been exploited in national breeding programs by selecting for increased growth rate.…”

mentioning

confidence: 99%

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Tizioto

Coutinho

Oliveira

et al. 2016

Sci Rep

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Residual feed intake (RFI), a measure of feed efficiency (FE), is defined as the difference between the observed and the predictable feed intake considering size and growth of the animal. It is extremely important to beef production systems due to its impact on the allocation of land areas to alternative agricultural production, animal methane emissions, food demand and cost of production. Global differential gene expression analysis between high and low RFI groups (HRFI and LRFI: less and more efficient, respectively) revealed 73 differentially expressed (DE) annotated genes in Longissimus thoracis (LT) muscle of Nelore steers. These genes are involved in the overrepresented pathways Metabolism of Xenobiotics by Cytochrome P450 and Butanoate and Tryptophan Metabolism. Among the DE transcripts were several proteins related to mitochondrial function and the metabolism of lipids. Our findings indicate that observed gene expression differences are primarily related to metabolic processes underlying oxidative stress. Genes involved in the metabolism of xenobiotics and antioxidant mechanisms were primarily down-regulated, while genes responsible for lipid oxidation and ketogenesis were up-regulated in HRFI group. By using LT muscle, this study reinforces our previous findings using liver tissue and reveals new genes and likely tissue-specific regulators playing key-roles in these processes.

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mentioning

confidence: 99%

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Tizioto

Coutinho

Oliveira

et al. 2016

Sci Rep

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“…Finally, genomic tools could be useful as was previously highlighted that some genomic regions were linked with FE characteristics in livestock species (Chen et al 2011;Wolc et al 2013;Al-Husseini et al 2014;Tran et al 2014). However, nothing has been reported to date on fish to our knowledge.…”

Section: Neuropeptides and Hormonesmentioning

confidence: 91%

Improving feed efficiency in fish using selective breeding: a review

Verdal

Komen

Quillet

et al. 2017

Reviews in Aquaculture

121

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Improving feed efficiency (FE) is key to reducing production costs in aquaculture and to achieving sustainability for the aquaculture industry. Feed costs account for 30–70% of total production costs in aquaculture; much work has been done on nutritional and husbandry approaches to improve FE but only a limited amount of research has been devoted to using genetics, despite its potential. This paper reviews past work to improve FE in fish using selective breeding and assess future directions. Direct selection on FE traits requires methods to measure individual feed consumption and estimate FE efficiently and accurately. This is particularly difficult to do in fish because of the environment in which they live. Many of the published studies on FE were found to be inaccurate because of methodological problems. The relatively low heritability estimates of FE traits in fish published to date are probably partly as a result of inaccurate measurements of feed intake. Improving ways to measure the individual feed intake with high accuracy will be critical to the successful application of genetics to improving FE. Indirect selection criteria that could be used to improve FE (including growth after starvation/refeeding, body composition, neuropeptides or hormone levels) are discussed. Promising approaches to measuring feed intake accurately that may enable these studies to be undertaken are identified. More work using these will be needed prior to assessing the practicality of the introduction of direct or indirect traits for FE in fish genetic improvement programmes.

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“…; Berry & Crowley ; Al‐Husseini et al . ). In the present study, we estimated RFI as a linear function of FI and its outputs to determine whether selection for RFI is a useful technique in common laying ducks.…”

Section: Descriptive Statistics For Residual Feed Intake (Rfi) and Egmentioning

confidence: 97%

Association analysis between feed efficiency studies and expression of hypothalamic neuropeptide genes in laying ducks

Zeng

Chen

et al. 2016

Animal Genetics

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Residual feed intake (RFI) is now considered a more reasonable metric to evaluate animal feed efficiency. In this study, the correlation between RFI and other feed efficiency traits was investigated and gene expression within the hypothalamus was determined in low RFI (LRFI) and high RFI (HRFI) ducks. Further, several hypothalamic neuropeptide genes were measured using quantitative real-time PCR. The mean feed intake value was 160 g/day, whereas the egg mass laid (EML) and body weight were approximately 62.4 g/day and 1.46 kg respectively. Estimates for heritability of RFI, feed conversion ratio (FCR) and feed intake were 0.26, 0.18 and 0.23 respectively. RFI is phenotypically positively correlated with feed intake and FCR (P < 0.01). The expression of neuropeptide Y (NPY) and neuropeptide Y receptor Y5 (NPY5R) mRNA was higher in HRFI ducks compared with LRFI ducks (P < 0.05), whereas that of proopiomelanocortin (POMC), melanocortin 4 receptor (MC4R) and cholecystokinin (CCK) was lower (P < 0.05). The mRNA expression of gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) (GNRH1) and prolactin receptor (PRLR) was unchanged between LRFI and HRFI ducks. The results indicate that selection for LRFI could reduce feed intake without significant changes in EML, whereas selection on FCR will increase EML.

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Expression of candidate genes for residual feed intake in Angus cattle

Cited by 33 publications

References 21 publications

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Improving feed efficiency in fish using selective breeding: a review

Association analysis between feed efficiency studies and expression of hypothalamic neuropeptide genes in laying ducks

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