Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment

Venkatesh, Sudhakar K.; Wang, Gang; Teo, Lynette; Ang, Bertrand

doi:10.1002/jmri.24084

Cited by 76 publications

(71 citation statements)

References 30 publications

(66 reference statements)

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“…Calculations of liver stiffness with MR elastography are highly reproducible and show excellent interobserver agreement (60)(61)(62). The high accuracy is probably related to the large volume of parenchymal sampling, with the potential to assess the stiffness of nearly the entire liver parenchyma.…”

Section: Mr Elastographymentioning

confidence: 94%

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Babu¹,

Wells²,

Teytelboym³

et al. 2016

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Section: Mr Elastographymentioning

confidence: 94%

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Babu¹,

Wells²,

Teytelboym³

et al. 2016

RadioGraphics

Self Cite

167

100

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“…40,41 Consistency in measurement is critically important for quantitative assessments including MRE. 10,12,42 Hines's group revealed only a minor effect of interobserver variability on overall variability of measurements using a linear mixed effect model in which the component sources of variability included day-to-day physiological changes in the subject and examinations were replicated on the same subject on the same day. 11 In addition, Shin's group recently reported a very low interobserver difference in stiffness measurements (³0.005 kPa) in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Validity and Reliability of Magnetic Resonance Elastography for Staging Hepatic Fibrosis in Patients with Chronic Hepatitis B

et al. 2015

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Purpose: We evaluated the validity and reliability of magnetic resonance elastography (MRE) for staging hepatic fibrosis in patients with chronic hepatitis B.Methods: The study included 73 patients with chronic hepatitis B and confirmed stages of pathological fibrosis. Two radiologists measured liver stiffness using MRE in all cases. We compared the area under the receiver operating characteristic (ROC) curve (Az) for distinguishing stages of fibrosis compared with MRE liver stiffness measurements and serum fibrosis markers. We used intraclass correlation coefficients to analyze interobserver agreement for measurements of liver stiffness and 2 one-sided t-tests to test the equivalence of the measurements by the 2 observers.Results: ROC analyses revealed the significantly superior discrimination abilities of MRE for liver fibrosis staging (Az = 0.945 to 0.978 [Observer 1] and 0.936 to 0.967 [Observer 2]) to those of serum fibrosis markers (0.491 to 0.742) for both observers (P < 0.0004). The intraclass correlation coefficient between the 2 observers was excellent (µ = 0.971), and the measurements of liver stiffness by the 2 observers were statistically equivalent within a 0.1-kPa difference (P = 0.0157) Conclusion: MRE is a valid and reliable technique for discriminating the stage of hepatic fibrosis in patients with chronic hepatitis B.

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“…In a recent meta-analysis, the sensitivity, specificity and AUROC area for staging 0-2 fibrosis versus stage 3-4 fibrosis were 0.92, 0.96, and 0.98, respectively [49]. LS obtained with MRE is highly reproducible [50]. Strain elastography relies on manual compression of the liver with the strain response reflective of tissue stiffness.…”

Section: Non-invasive Assessmentmentioning

confidence: 98%

“…Examination time is also longer and requires access to an MRI facility. Contraindications to performing MRE include cardiac pacemaker and severe claustrophobia [44,45,50,63,64]. A comparison of the different elastography techniques is summarized in TABLE 2.…”

Section: Advantages and Limitationsmentioning

confidence: 99%

Non-invasive assessment of liver fibrosis and prognosis

Hagan

Asrani

Talwalkar

2015

Expert Review of Gastroenterology & Hepatology

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Over the past decade, several advances have been made in the non-invasive assessment of liver fibrosis. Both serum markers and imaging-based tissue elastography predict the presence of advanced fibrosis compared with liver biopsy. Serum markers may be indirect or direct markers of liver structure and function. Imaging-based techniques measure liver stiffness as a surrogate for fibrosis and include ultrasound and MRI-based methods. Most non-invasive techniques work well at identifying subjects at the extremes of fibrosis but may not accurately discern intermediate stages. In addition to being a diagnostic tool, elastography may have an evolving role in prognosis. Increasing stiffness is associated with higher rates of liver decompensation, need for transplantation, hepatocellular carcinoma, and death. There are special populations of patients where elastography may serve as a non-invasive method to impart useful clinical information, such as patients after liver transplantation, those with congenital heart disease and those being treated for chronic viral hepatitis. The role of non-invasive markers in accurately predicting the presence of fibrosis in obese patients needs to be further refined.

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Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment

Abstract: The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible.

Cited by 76 publications

References 30 publications

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Validity and Reliability of Magnetic Resonance Elastography for Staging Hepatic Fibrosis in Patients with Chronic Hepatitis B

Non-invasive assessment of liver fibrosis and prognosis

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