Frontotemporal Cortical Thinning in Amyotrophic Lateral Sclerosis

d’Ambrosio, Alessandro; Gallo, Angela; Trojsi, Francesca; Corbo, Daniele; Esposito, Fabrizio; Cirillo, Mario; Monsurrò, Maria Rosaria; Tedeschi, Gioacchino

doi:10.3174/ajnr.a3753

Cited by 24 publications

(22 citation statements)

References 55 publications

(120 reference statements)

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“…In addition to the cortical thinning of the precentral gyrus, cortical thickness measurements were found to be altered in multiple brain areas encompassing (predominantly right‐sided) frontal, insular, temporal, parietal, and occipital regions in both MND‐motor and MND‐plus patients. The evidence of a distributed involvement of extra‐motor areas in MND confirms recent pathological data [Brettschneider et al, ] and previous neuroimaging studies [Agosta et al, ; d'Ambrosio et al, ; Mezzapesa et al, ; Schuster et al, ; Thorns et al, ; Verstraete et al, ]. In all cortical regions, we found a trend toward a more severe thinning in MND‐plus relative to MND‐motor patients underscoring the morphological continuum within the MND spectrum.…”

Section: Discussionsupporting

confidence: 91%

Structural brain correlates of cognitive and behavioral impairment in MND

Agosta

Ferraro

Riva

et al. 2016

Human Brain Mapping

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Section: Discussionsupporting

confidence: 91%

Structural brain correlates of cognitive and behavioral impairment in MND

Agosta

Ferraro

Riva

et al. 2016

Human Brain Mapping

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“…We found regional brain atrophy of the motor cortex particularly in the frontal lobe and postcentral gyri, supramarginal gyri, angular gyri, and parietal operculum in the parietal lobe, all consistent with previous findings [9, 11, 21, 22, 60–63]. All of these regions participated in motor performance or motor imagery [64] and GM losses in these regions reflected dysfunctions of both motor performance and motor imagery in ALS [37].…”

Section: Discussionsupporting

confidence: 90%

Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis

Zhang

Mao

Jin

et al. 2014

BioMed Research International

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Conflicting findings have been reported regarding the lateralized brain abnormality in patients with amyotrophic lateral sclerosis (ALS). In this study, we aimed to investigate the probable lateralization of gray matter (GM) atrophy in ALS patients. We focused on the relationship between the asymmetry in decreased GM volume and the side of disease onset in patients with limb-onset. Structural imaging evaluation of normalized atrophy (SIENAX) and voxel-based morphometry (VBM) were used to assess differences in global and local brain regions in patients with heterogeneous body onset and subgroups with different side of limb-onset. We found global brain atrophy and GM losses in the frontal and parietal areas in each patient group as well as left predominant GM losses in the total cohort. The intriguing findings in subgroup analyses demonstrated that the motor cortex in the contralateral hemisphere of the initially involved limb was most affected. We also found that regional brain atrophy was related to disease progression rate. Our observations suggested that side of limb-onset can predict laterality of GM loss in ALS patients and disease progression correlates with the extent of cortical abnormality.

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“…Components of the SMN were previously indicated as involved in the planning, execution and controlling of voluntary movements (Biswal et al, 1995). Alterations in this network can help to explain the motor features of the disease, which are corroborated by anatomical deterioration and correlated with disease duration and progression (d'Ambrosio et al, 2014;Agosta et al, 2012;Verstraete et al, 2010). The changes in fALFF and ReHo measures found in our study may help to explain the difficulties ALS patients present in starting and controlling voluntary movements, even before structural damage is established or detectable at MRI.…”

Section: Discussionsupporting

confidence: 69%

Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

et al. 2019

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Resting state functional magnetic resonance imaging (rs-fMRI) has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of non-demented ALS patients compared with healthy controls. As expected, we found the sensorimotor network (SMN) with changes in fALFF and ReHo but also found the default mode (DMN), frontoparietal (FPN), salience (SN) networks altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of nonmotor regions, including those responsible for cognition.

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Frontotemporal Cortical Thinning in Amyotrophic Lateral Sclerosis

Cited by 24 publications

References 55 publications

Structural brain correlates of cognitive and behavioral impairment in MND

Structural brain correlates of cognitive and behavioral impairment in MND

Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis

Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

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