Neuropsychological performance in children with temporal lobe epilepsy having normal MRI findings

Mankinen, Katariina; Harila, Marika; Rytky, Seppo; Pokka, Tytti; Rantala, Heikki

doi:10.1016/j.ejpn.2013.08.005

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Other basic neuropsychological tests for assessing memory span, attention, working memory, and visuo‐spatial memory did not reveal any differences between the patients and their control group. These results are consistent with Mankinen et al () who showed that neuropsychological performance did not differ for children with temporal lobe epilepsy with normal MRI findings and their controls. Thus, our study supports the idea that such neuropsychological processes did not form the basis of the alterations detected here.…”

Section: Discussionsupporting

confidence: 92%

Spatial memory alterations in children with epilepsy of genetic origin or unknown cause

Cimadevilla¹,

Lizana²,

Roldán³

et al. 2014

Epileptic Disorders

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Genetic generalised epilepsy or epilepsy of unknown cause can remit before adolescence. In many children, the disease does not interfere with their academic achievement. Although there are neuropsychological studies characterising the cognitive profile, there are no studies in this population focused on spatial orientation abilities. In this study, we compared children with genetic generalised epilepsy or epilepsy of unknown cause with a control group using a virtual spatial learning task. Children with epilepsy showed worse performance on the spatial orientation task, although their visuo‐spatial memory, attention, and working memory were normal. These results confirm that genetic generalised epilepsy or epilepsy of unknown cause is associated with more cognitive deficits. Virtual reality technologies can complement clinical assessment.

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Section: Discussionsupporting

confidence: 92%

Spatial memory alterations in children with epilepsy of genetic origin or unknown cause

Cimadevilla¹,

Lizana²,

Roldán³

et al. 2014

Epileptic Disorders

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“…In our sample some kind of neurodevelopmental delay or other neurological finding was present in 60% of patients which was quite high, and among those were children with mild, as well as severe clinical manifestations. Some studies have found that female gender, early onset, longer duration and abnormal interictal EEG have a negative effect on neuropsychological performance in children with temporal lobe epilepsy, an that children with early-onset epilepsy should be assessed carefully for neuropsychological impairment using sufficiently broad batteries of tests in order to detect even slight deficits ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Interictal Electroencephalography (EEG) Findings in Children with Epilepsy and Bilateral Brain Lesions on Magnetic Resonance Imaging (MRI)

Zubčević¹,

Milos²,

Čatibušić³

et al. 2015

Acta Inform Med

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Introduction:Neuroimaging procedures and electroencephalography (EEG) are basic parts of investigation of patients with epilepsies.Aim:The aim is to try to assess relationship between bilaterally localized brain lesions found in routine management of children with newly diagnosed epilepsy and their interictal EEG findings.Patients and methods:Total amount of 68 patients filled criteria for inclusion in the study that was performed at Neuropediatrics Department, Pediatric Hospital, University Clinical Center Sarajevo, or its outpatient clinic. There were 33 girls (48,5%) and 35 boys (51,5%). Average age at diagnosis of epilepsy was 3,5 years.Results:Both neurological and neuropsychological examination in the moment of making diagnosis of epilepsy was normal in 27 (39,7%) patients, and showed some kind of delay or other neurological finding in 41 (60,3%). Brain MRI showed lesions that can be related to antenatal or perinatal events in most of the patients (ventricular dilation in 30,9%, delayed myelination and post-hypoxic changes in 27,9%). More than half of patients (55,9%) showed bilateral interictal epileptiform discharges on their EEGs, and further 14,7% had other kinds of bilateral abnormalities. Frequency of bilateral epileptic discharges showed statistically significant predominance on level of p<0,05. Cross tabulation between specific types of bilateral brain MRI lesions and EEG finding did not reveal significant type of EEG for assessed brain lesions.Conclusion:We conclude that there exists relationship between bilaterally localized brain MRI lesions and interictal bilateral epileptiform or nonspecific EEG findings in children with newly diagnosed epilepsies. These data are suggesting that in cases when they do not correlate there is a need for further investigation of seizure etiology.

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“…Second, the age of the patients seems to be a critical factor. Indeed, a very recent study found no difference in neuropsychological performances in children with temporal lobe epilepsy (Mankinen et al, 2014 ) whilst a study with animal models has shown that early-life seizures are key events that contribute to deficits in learning (Lugo et al, 2014 ). In this current study, our patients did not experience a long history of seizures, which can explain the absence of associative learning impairment.…”

Section: Discussionmentioning

confidence: 99%

Acquired equivalence associative learning in GTC epileptic patients: experimental and computational study

Khalil

El-Fetoh

Moftah

et al. 2015

Front. Cell. Neurosci.

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Previous cognitive behavioral studies based on Acquired Equivalence Associative learning Task (AEALT) showed a strong relation between hippocampus and basal ganglia in associative learning. However, experimental behavioral studies of patients with Generalized Tonic Clonic (GTC) epilepsy remained sparse. The aim of the present study is to integrate a classical behavioral cognitive analysis with a computational model approach to investigate cognitive associative learning impairments in patients with GTC epilepsy. We measured the accuracy of associative learning response performance in five GTC epileptic patients and five control subjects by using AEALT, all subjects were matched in age and gender. We ran the task using E-Prime, a neuropsychological software program, and SPSS for data statistical analysis. We tested whether GTC epileptic patients would have different learning performance than normal subjects, based on the degree and the location of impairment either in basal ganglia and/or hippocampus. With the number of patients that was available, our behavioral analysis showed no remarkable differences in learning performance of GTC patients as compared to their control subjects, both in the transfer and acquisition phases. In parallel, our simulation results confirmed strong connection and interaction between hippocampus and basal ganglia in our GTC and their control subjects. Nevertheless, the differences in neural firing rate of the connectionist model and weight update of basal ganglia were not significantly different between GTC and control subjects. Therefore, the behavioral analysis and the simulation data provided the same result, thus indicating that the computational model is likely to predict cognitive outcomes.

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Neuropsychological performance in children with temporal lobe epilepsy having normal MRI findings

Cited by 7 publications

References 23 publications

Spatial memory alterations in children with epilepsy of genetic origin or unknown cause

Spatial memory alterations in children with epilepsy of genetic origin or unknown cause

Interictal Electroencephalography (EEG) Findings in Children with Epilepsy and Bilateral Brain Lesions on Magnetic Resonance Imaging (MRI)

Acquired equivalence associative learning in GTC epileptic patients: experimental and computational study

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