The association between galectin-3 and occurrence of reinfarction early after first myocardial infarction treated invasively

Szadkowska, Iwona; Wlazeł, Rafał Nikodem; Migała, Marta; Bajon-Laskowska, Karolina; Szadkowski, Krzysztof; Zielińska, Marzenna; Paradowski, Marek; Pawlicki, Lucjan

doi:10.3109/1354750x.2013.840801

Cited by 19 publications

(16 citation statements)

References 23 publications

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“…Hence, with the strength of a prospective cohort study design and of a large cohort of consecutively enrolled patients, our data demonstrate that Gal-3 predicts cardiovascular mortality in patients with CAD regardless of the presence or absence of left ventricular systolic dysfunction. This finding is at variance with previous reports in the general population, 24 in smaller CAD cohorts, [13][14][15][16] and in a large cohort of patients with angiographically demonstrated CAD. 32 A prognostic role of Gal-3 on nonfatal cardiovascular events could not, however, be confirmed at variance with previous studies, [13][14][15][16] possibly because in those cohorts most of the effect on cumulative end points was driven by heart failure-related events.…”

Section: Subgroup Analysescontrasting

confidence: 56%

“…This finding is at variance with previous reports in the general population, 24 in smaller CAD cohorts, [13][14][15][16] and in a large cohort of patients with angiographically demonstrated CAD. 32 A prognostic role of Gal-3 on nonfatal cardiovascular events could not, however, be confirmed at variance with previous studies, [13][14][15][16] possibly because in those cohorts most of the effect on cumulative end points was driven by heart failure-related events. Another possibility is that adjustment for the Duke CAD Index Score, one of the strongest predictors of cardiovascular events and death in patients with CAD, might have concealed an effect of Gal-3 on these end points in the our study.…”

Section: Subgroup Analysescontrasting

confidence: 56%

“…23 Gal-3 was shown to predict all-cause and cardiovascular death, and incident heart failure also in healthy subjects, 19,24,25 in patients with peripheral artery disease, 17 and in those with acute coronary syndrome. In the latter, it also predicted hospitalizations for heart failure, 14 reinfarction, 15 heart failure, and cardiovascular mortality. 13,16 Thus, our findings extend to the patients with CAD, the adverse prognostic role of high Gal-3.…”

Section: Prognostic Effect Of Gal-3mentioning

confidence: 99%

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Galectin-3 Predicts Long-Term Cardiovascular Death in High-Risk Patients With Coronary Artery Disease

Maiolino

Rossitto

Pedon

et al. 2015

ATVB

101

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Objective— Galectin-3 (Gal-3) can affect atherogenesis by multiple mechanisms, but it remains scarcely known whether plasma Gal-3 levels predict cardiovascular events in patients with coronary artery disease. Therefore, we investigated if Gal-3 predicts cardiovascular death in patients with coronary artery disease of the Genetic and ENvironmental factors In Coronary Artery disease study. Approach and Results— In a prospective cohort study, we measured the plasma levels of Gal-3 in 1013 randomly selected patients who underwent coronary angiography and long-term follow-up to assess incident cardiovascular events. The primary end points were (1) cardiovascular death and (2) a composite of cardiovascular death, acute coronary syndrome, and stroke. Secondary end points entailed (1) acute myocardial infarction, (2) stroke, and (3) a composite fatal ischemic event including fatal myocardial infarction and stroke. The effect of Gal-3 on prognosis was assessed using Kaplan–Meier analysis and multivariate Cox’s regression. During long-term follow-up (median, 7.2 years), 115 cardiovascular deaths occurred (15.2%), more commonly in the high Gal-3 tertile (25.2%) than in the intermediate and the low tertiles (13.6% versus 7.5%, respectively; P <0.001). The adverse prognostic effect of high Gal-3 was confirmed in subgroup analysis of the patients with angiographically documented coronary artery disease and also of those with a normal left ventricular ejection fraction. At multivariate analysis, Gal-3 was a predictor of cardiovascular mortality (hazard ratio, 1.79; 95% confidence interval, 1.10–2.93; P =0.020) along with age, left ventricular ejection fraction, and coronary atherosclerotic burden. Conclusions— In high cardiovascular risk patients referred for coronary angiography Gal-3 is a strong independent predictor of cardiovascular death.

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Section: Subgroup Analysescontrasting

confidence: 56%

Section: Subgroup Analysescontrasting

confidence: 56%

Section: Prognostic Effect Of Gal-3mentioning

confidence: 99%

See 1 more Smart Citation

Galectin-3 Predicts Long-Term Cardiovascular Death in High-Risk Patients With Coronary Artery Disease

Maiolino

Rossitto

Pedon

et al. 2015

ATVB

101

View full text Add to dashboard Cite

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“…In the same cohort, the Authors reported Gal-3 might be an independent predictor of re-infarction early after first MI [52].…”

Section: Gal-3 and Prognosismentioning

confidence: 87%

“…Some Authors evaluated the potential role of Gal-3 as a predictive marker of mortality, HF, atrial fibrillation (AF) and re-infarction in ACS patients [8,33,38,[50][51][52].…”

Section: Gal-3 and Prognosismentioning

confidence: 99%

Galectin-3 in acute coronary syndrome

Agnello

Bivona

Sasso

et al. 2017

Clinical Biochemistry

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Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

Brás

Toba

et al. 2014

Pflugers Arch - Eur J Physiol

119

136

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The cardiac extracellular matrix (ECM) fills the space between cells, supports tissue organization, and transduces mechanical, chemical, and biological signals to regulate homeostasis of the left ventricle (LV). Following myocardial infarction (MI), a multitude of ECM proteins are synthesized to replace myocyte loss and form a reparative scar. Activated fibroblasts (myofibroblasts) are the primary source of ECM proteins, thus playing a key role in cardiac repair. A balanced turnover of ECM through regulation of synthesis by myofibroblasts and degradation by matrix metalloproteinases (MMPs) is critical for proper scar formation. In this review, we summarize the current literature on the roles of myofibroblasts, MMPs, and ECM proteins in MI-induced LV remodeling. In addition, we discuss future research directions that are needed to further elucidate the molecular mechanisms of ECM actions to optimize cardiac repair.

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The association between galectin-3 and occurrence of reinfarction early after first myocardial infarction treated invasively

Abstract: Galectin-3 might be an additional useful biomarker in prediction for reinfarction early after first MI.

Cited by 19 publications

References 23 publications

Galectin-3 Predicts Long-Term Cardiovascular Death in High-Risk Patients With Coronary Artery Disease

Galectin-3 Predicts Long-Term Cardiovascular Death in High-Risk Patients With Coronary Artery Disease

Galectin-3 in acute coronary syndrome

Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

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