241. type I Interferons Alter the Response of Neutrophils to Inflammatory Cytokines

Glennon‐Alty, Laurence; Moots, Robert J.; Edwards, Steven W.; Wright, Helen L.

doi:10.1093/rheumatology/kex062.243

Cited by 1 publication

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“…One possible explanation may be that the placenta of the female fetus protects them from adverse prenatal events [29]. This explanation is further evident in previous studies that showed that sex differences exist in clinical outcomes of various inflammatory disorders such as rheumatoid arthritis (RA) and sepsis [30][31][32].…”

Section: Discussionmentioning

confidence: 85%

Human cord plasma proteomic analysis reveals sexually dimorphic proteins associated with intrauterine growth restriction

Akinyemi,

Du,

Aguilan

et al. 2023

Proteomics

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Intrauterine growth restriction (IUGR) is associated with increased risk of cardiometabolic disease later in life and has been shown to affect female and male offspring differently, but the mechanisms remain unclear. The purpose of this study was to identify proteomic differences and metabolic risk markers in IUGR male and female neonates when compared to appropriate for gestational age (AGA) babies that will provide a better understanding of IUGR pathogenesis and its associated risks. Our results revealed alterations in IUGR cord plasma proteomes with most of the differentially abundant proteins implicated in peroxisome pathways. This effect was evident in females but not in males. Furthermore, we observed that catalase activity, a peroxisomal enzyme, was significantly increased in females (p < 0.05) but unchanged in males. Finally, we identified risk proteins associated with obesity, type‐2 diabetes, and glucose intolerance such as EGF containing fibulin extracellular matrix protein 1 (EFEMP1), proprotein convertase subtilisin/kexin type 9 (PCSK9) and transforming growth factor beta receptor 3 (TGFBR3) proteins unique to females while coagulation factor IX (C9) and retinol binding protein 4 (RBP4) are unique in males. In conclusion, IUGR may display sexual dimorphism which may be associated with differences in lifelong risk for cardiometabolic disease between males and females.

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