241 Particularities of the epidemiology of lower-extremities peripheral artery disease in Central Africa

Guerchet, Maëlenn; Aboyans, Victor; M’Belesso, Pascal; Mouanga, Alain Maxime; Salazar, Johanna; Bandzouzi, B.; Tabo, André; Lacroix, Philippe; Preux, Pierre‐Marie

doi:10.1016/s1878-6480(10)70243-3

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Population based studies have previously reported an association of PAD with female sex [33] and hypertension [34], which we have also shown in our study. In our clinic, the majority of the patients are of the female sex [35].…”

Section: Discussionsupporting

confidence: 90%

“…In the multivariable-adjusted analysis, we found that female sex, current high blood pressure, and use of glibenclamide were predictive of PAD. Population based studies have previously reported an association of PAD with female sex [ 33 ] and hypertension [ 34 ], which we have also shown in our study. In our clinic, the majority of the patients are of the female sex [ 35 ].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Prevalence of lower extremity Peripheral artery disease among adult diabetes patients in Southwestern Uganda

Okello

Millard

Rogers

et al. 2014

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundPeripheral artery disease (PAD) is a major complication of atherosclerosis. PAD can be diagnosed with low-cost diagnostic techniques and is associated with significant morbidity and mortality. While the major epidemiologic risk factors for PAD have been established in the western world, data from resource-poor countries are limited. We performed a cross-sectional study to determine the prevalence and correlates of PAD among patients with diabetes at Mbarara Referral Hospital in southwestern Uganda.MethodsWe consecutively enrolled diabetes patients aged 50 years or greater presenting to the outpatient clinic. We collected blood for fasting lipid profile, HIV serology, and glycosylated hemoglobin, measured blood pressure and ankle brachial index, and administered the Edinburgh Claudication Questionnaire (ECQ). We also surveyed patients for other PAD risk factors. We used logistic regression to determine correlates of PAD.ResultsWe enrolled 229 diabetes patients. The median age of 60 years (IQR 55–66), and 146 (63.7%) were female. Fifty five patients (24%) had PAD (ABI of ≤ 0.9). Of these, 48 /55 (87.27%) had mild PAD (ABI 0.71-0.9) while 7/55 (12.73%) had moderate to severe PAD (ABI < 0.7). Amongst those with PAD, 24/55 (43.64%) reported claudication by the ECQ. Correlates of PAD included female sex (AOR 2.25, 95% CI 1.06 - 4.77, p = 0.034), current high blood pressure (AOR 2.59, 95% CI 1.25-5.33, p = 0.01), and being on a sulfonylurea–glibenclamide (AOR 3.47, 95% CI 1.55 - 7.76, p = 0.002).ConclusionPAD was common in diabetic patients in southwestern Uganda. Given its low cost and ease of measurement, ABI deserves further assessment as a screening tool for both PAD and long term cardiovascular risk amongst diabetics in this region.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Prevalence of lower extremity Peripheral artery disease among adult diabetes patients in Southwestern Uganda

Okello

Millard

Rogers

et al. 2014

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Studies have also reported an association of PAD with hypertension 23 and in our study, although the prevalence of PAD was higher among clients with hypertension, there was no significant association between PAD and hypertension. In another multi-racial cross sectional study performed in Malaysia, Asia to determine the prevalence of ABI in 200 diabetic patients at a primary care setting, the overall prevalence of PAD was 16% in this diabetic population.…”

Section: Discussioncontrasting

confidence: 65%

The Prevalence of Lower Extremity Peripheral Artery Disease among Adults with Type 2 Diabetes Mellitus Attending a Teaching Hospital in Ghana

2016

IJSR

View full text Add to dashboard Cite

Background: Peripheral artery disease (PAD) indicates generalized atherosclerosis and thus carries a very high risk for cardiovascular morbidity and mortality and is usually extensive and severe when associated with diabetes. Ankle Brachial Index (ABI) is a single, non-invasive and reliable bedside method for diagnosing the presence and severity of PAD. Objectives of the study was to estimate the prevalence of PAD in the lower limbs among adult type 2 diabetic clients and to assess any associations between PAD and selected clinical factors like sex, age, hypertension and duration of diabetes. Methods: A cross-sectional descriptive study was conducted between January, 2015 through April, 2015 among patients with diabetes attending the diabetes clinic at Cape Coast teaching hospital, Ghana. A pre-coded questionnaire was used to collect data by face to face interview, and ABI measurement was done for each client. An ABI of <0.9 was considered diagnostic of PAD. Results: A total of 200 adult clients with diabetes with a female predominance (71.5% females; 28.5% males) participated in the study. Majority were within the 50-59 and 60-69 age groups. Majority (34.5%) of the clients reported duration of their diabetes diagnosis between 5-10 years. The prevalence of PAD among the study clients on the right and left lower limbs were 17.5% and 18.0% respectively with preponderance in female clients. Of these, 22/35 (62.9%) had mild PAD on the right leg and 24/36 (66.7%) on the left leg whiles 13/35 (37.1%) had moderate PAD on the right leg and 12/36 (33.3%) on the left leg respectively with no severe disease noted. PAD was associated with duration of diabetes (p<0.05). Majority (88.5%) of the clients had hypertension co-morbidity. Conclusions: PAD is common among adult type 2clients with diabetes in Ghana and early screening and treatment by medical professionals needs to be emphasized to help lower subsequent morbidity and mortality and systemic atherosclerotic diseases.

show abstract

“…Worldwide PAD prevalence varies between 4.5 to 57% and between 10 and 50% in an African population (1)(2)(3)(4). Smoking, diabetes mellitus, hypertension dyslipidaemia, age and genetic factors predispose to development of leg PAD (5).…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Progression and Associated Risk Factors of Asymptomatic Peripheral Arterial Disease

Mehta¹,

Ogendo²,

Mark³

2018

Ann Afr Surg.

View full text Add to dashboard Cite

Introduction:The prevalence of peripheral arterial disease (PAD) ranges between 4.5% and 57% and is independently associated with cardiovascular disease burden irrespective of symptoms. Two thirds of cases are thought to be asymptomatic and may go unrecognised. Local prevalence and natural progression of asymptomatic PAD is unknown. Methods: This one year, non-interventional longitudinal study, aimed to determine prevalence and progression of asymptomatic PAD in patients with cardiovascular risk factors. Results: Of 217 patients screened, 36% had asymptomatic disease in 113 legs. Of sixty two who returned for follow-up, eight normal legs developed asymptomatic PAD, and 46%, asymptomatic at baseline showed disease progression. Initial baseline ABI showed significant change over 1 year of follow-up (p=0.001) and 21% (13) of patients eventually developed intermittent claudication. Also, 52% of baseline asymptomatic participants having at least one associated cardiovascular risk factor showed disease progression over 1 year. Those developing claudication demonstrated significant ABI deterioration. Having two or more cardiovascular risk factors significantly affected progression of asymptomatic disease, (p = 0.031). Conclusion: Study confirms high prevalence of asymptomatic PAD in our population and significant disease progression in one year.

show abstract

241 Particularities of the epidemiology of lower-extremities peripheral artery disease in Central Africa

Cited by 3 publications

References 0 publications

Prevalence of lower extremity Peripheral artery disease among adult diabetes patients in Southwestern Uganda

Prevalence of lower extremity Peripheral artery disease among adult diabetes patients in Southwestern Uganda

The Prevalence of Lower Extremity Peripheral Artery Disease among Adults with Type 2 Diabetes Mellitus Attending a Teaching Hospital in Ghana

Prevalence, Progression and Associated Risk Factors of Asymptomatic Peripheral Arterial Disease

Contact Info

Product

Resources

About