Prevalence and factors related to urinary albumin excretion in obese youths

Lurbe, Empar; Torró, María Isabel; Álvarez, Julio; Aguilar, Francisco; Fernández-Formoso, José Antonio; Redón, Josep

doi:10.1097/hjh.0b013e328364bcbf

Cited by 31 publications

(25 citation statements)

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“…Prior work has suggested that microalbuminuria in obese youth is related with cardiometabolic risk factors such as WC and the level of TG, and it is suggested that the central body fat distribution is related to renal function impairment [6]. Also consistent with our findings, we note that there is a data that suggests microalbuminuria is associated with metabolic syndrome in obese children and adolescents [24].…”

Section: Discussionsupporting

confidence: 91%

“…According to the available literature, however, the prevalence of microalbuminuria in obese children ranges from 0.3% to 23.9%, with significant variation [9,20,21]. Similar to the results of this study, a recent report determined that the prevalence of microalbuminuria in obese Spanish youth was 2.4% and not prominent in obese children [6]. Goknar et al also reported that microalbuminuria was not found to be different between obese children and healthy controls [8].…”

Section: Discussionsupporting

confidence: 84%

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Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth: Data from the Korea National Health and Nutrition Examination Survey

Cho

Kim

2017

PLoS ONE

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BackgroundMicroalbuminuria is a known early predictive factor for renal and cardiovascular diseases, not only for patients with diabetes mellitus or hypertension but also in the general population. However, the prevalence and risk factors associated with microalbuminuria in Korean youth are unknown.ObjectivesThe aims of this study are to evaluate the prevalence of microalbuminuria and the association between microalbuminuria and obesity or cardiometabolic risk factors in Korean children and adolescents without diabetes.MethodsThis study examines data obtained from the Korea National Health and Nutrition Examination Survey (between 2011 and 2014). It includes a total of 1,976 participants aged between 10 and 19 years (boys 1,128 and girls 848). Microalbuminuria was defined as a urine albumin-to-creatinine ratio (UACR) of ≥ 30 mg/g and < 300 mg/g. Association between microalbuminuria and the risk factors for cardiometabolic diseases including insulin resistance was evaluated.ResultsThe prevalence of microalbuminuria was found to be 3.0% in Korean children and adolescents over this time period. The mean UACR for non-obese youth was significantly greater than that found in obese youth (3.2 ± 0.1 mg/g in the non-obese group vs. 2.1 ± 0.2 mg/g in the obese group; P < 0.001). In multiple logistic regression analysis, microalbuminuria was associated with hyperglycemia (OR 2.62, 95% CI 1.09–6.30) and hemoglobin A1c (OR 3.34, 95% CI 1.09–10.17) in the non-obese group and hypertension (OR 14.10, 95% CI 1.12–177.98) and HbA1c (OR 6.68, 95% CI 1.87–23.95) in the obese group.ConclusionsThe prevalence of microalbuminuria is not prominent in obese children and adolescents. Our findings demonstrated that the presence of hypertension and hyperglycemia was associated with microalbuminuria. Especially Hemoglobin A1c was associated with microalbuminuria in youths regardless of weight status. Microalbuminuria in pediatric population can be a helpful marker for the risk of cardiovascular disease.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 84%

Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth: Data from the Korea National Health and Nutrition Examination Survey

Cho

Kim

2017

PLoS ONE

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“…Consistent with the prevalence of about 10% in obese adolescents (30), we found that 8.5% of the obese children in our group had MA. Another more recent study of Lurbe et al (31) identified in Spain a prevalence of 2.4% of MA in obese youths thus suggesting the existence of important confounding variables, e.g. orthostatic proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Childhood obesity, renal injury and future disease risk

Lateva

Bliznakova

Galcheva

et al. 2017

SSM

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“…On the other hand, several referral-based studies have consistently shown that among obese adolescent outpatients, those who have an insulin-resistant phenotype; for example, higher fasting or post-challenge insulin and/or glucose and/or more severe obesity, are at increased risk for MA [6][7][8][9][10]. Furthermore, the NHANES [3] reported that cardiovascular risk factors (impaired fasting glucose, IR, hypertension and smoking) were associated with MA among overweight and obese adolescents but not among normal-weight participants, suggesting that obesity-mediated IR is the key pathogenetic link between cardiovascular risk factors and MA among adolescents.…”

Section: Microalbuminuriamentioning

confidence: 99%

“…The NHANES [3] has indicated that IR as defined as a homeostasis model assessment of IR (HOMA-IR) of ≥4 (15% of subjects) is the strongest risk factor for MA, with an unadjusted odds ratio (OR) of 19 [1.89-189]. In contrast, MS, lipid levels and blood pressure have not always been proven to be predictors of MA in obese children and adolescents [7,9,11]. Studies on diabetic youth have further reinforced the notion that IR is an important causative risk factor for MA.…”

Section: Microalbuminuriamentioning

confidence: 99%

Urogenital Complications: Renal Disease, Urolithiasis and Lower Urinary Tract Symptoms

Morandi¹,

Maffeis²

2015

Metabolic Syndrome and Obesity in Childhood and Adolescence

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The chapter contains a critical review of the current literature pertaining to the consequences of childhood and adolescent obesity/metabolic syndrome on the urogenital system, with a particular focus on microalbuminuria, renal disease, urolithiasis and lower urinary tract symptoms. The clinical implications of the current evidence with regard to the relationship between early obesity/ metabolic syndrome and the above-mentioned conditions are discussed. © 2015 S. Karger AG, Basel Renal DiseaseObesity and metabolic syndrome (MS) have been associated with renal damage in adults [1]. Obesity directly favors renal damage through several mechanisms [1] ( fig. 1). The obesity-related activation of the renin-angiotensin-aldosterone system is one of the most extensively studied mechanisms explaining renal injury driven by obesity [1]. Adipocytes possess a renin-angiotensin system and produce angiotensin II, thus stimulating the production of aldosterone [1]. Moreover, adipose tissue also secretes angiotensin-independent mineralocorticoid-releasing factors [1]. Thus, obesity is associated with a state of hyperaldosteronism leading to plasma expansion, glomerular hyperfiltration and damage and proteinuria, which often occurs in parallel with a state of pre-hypertension [1]. Aldosterone has also been shown to have direct negative glomerular effects in animal models, independent of blood pressure and plasma expansion [1].An obesity-associated decrease in adiponectin levels is another mechanism of renal damage because of the resultant reduced AMP-activated protein kinase in glomerular

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Prevalence and factors related to urinary albumin excretion in obese youths

Abstract: The prevalence of elevated urinary albumin excretion is not prominent in obese children, and when it is increased, it depends mainly on metabolic factors.

Cited by 31 publications

References 32 publications

Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth: Data from the Korea National Health and Nutrition Examination Survey

Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth: Data from the Korea National Health and Nutrition Examination Survey

Childhood obesity, renal injury and future disease risk

Urogenital Complications: Renal Disease, Urolithiasis and Lower Urinary Tract Symptoms

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