Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma

Mihaljevic, André L.; Rieger, Andreas; Belloni, Benedetta; Hein, Rüdiger; Okur, Asli; Scheidhauer, Klemens; Schuster, Tibor; Friess, Helmut; Martignoni, Marc E.

doi:10.1016/j.ejso.2013.09.005

Cited by 50 publications

(21 citation statements)

References 15 publications

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“…Additionally, a 3D system has been developed [98,149] that allows the surgeon to visualize the SLN in real-time using 3D navigation. Both technical developments may simplify and speed up the SLNB procedure and also enable reliable detection of SLNs in anatomically complex regions such as the head and neck, where it is difficult to locate SLNs [97,99,102]. Further prospective studies are necessary to evaluate the field of indications for these novel intraoperative probes and to investigate their cost-effectiveness.…”

Section: Radioactive Clinical Wastementioning

confidence: 97%

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EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

Bluemel

Herrmann

Giammarile

et al. 2015

Eur J Nucl Med Mol Imaging

114

131

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Section: Radioactive Clinical Wastementioning

confidence: 97%

“…Also, SLNs may be hidden by the injection site, as is often observed in malignancies in the head and neck region (shine-through phenomenon). In these challenging settings, using three-dimensional imaging and navigation [97][98][99] or a portable gamma camera [100][101][102] may improve intraoperative detection of SLNs.…”

Section: Gamma Camerasmentioning

confidence: 99%

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

Bluemel

Herrmann

Giammarile

et al. 2015

Eur J Nucl Med Mol Imaging

114

131

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“…Encouraging results have been reported in patients with melanoma and breast cancer [12,13] as well as initial reports in tumours of the head and neck (HN) region [8,11,[14][15][16][17][18]. Once validated, this system has the potential to replace conventional outpatient-based SPECT-CT imaging with an intraoperative technique and open new applications for sentinel node biopsy in previously inaccessible tumours.…”

Section: Introductionmentioning

confidence: 89%

“…This device was successfully evaluated in breast cancer and melanoma [12,13]. A review of the literature on fhSPECT for visualization and localization of SLNs in patients with HN SCC revealed seven publications including case series and single case reports [8,11,[14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 98%

Role of intraoperative sentinel node imaging in head and neck cancer

Schilling

Corrado

Gnanasegaran

et al. 2015

Clin Transl Imaging

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At the present time, there is a dilemma concerning the best management of the neck in patients presenting with early head and neck squamous cell carcinoma (HNSCC). Occult cervical metastasis is found in up to a quarter of HNSCC patients with radiologically N0 necks, and for this reason, conventional treatment includes elective neck dissection (END) alongside tumour excision. Sentinel node biopsy (SNB) offers an alternative accurate and minimally invasive method of staging the neck, which has been safely applied to oral cancer. SNB is a patientspecific procedure which has an enhanced recovery compared to END but is currently not widely offered to patients. There are exciting developments in the technology supporting SNB, improving the accuracy and ease of the procedure and opening up the technique to new tumour types. We describe our experiences in using a novel intraoperative navigation device for sentinel node retrieval and review other advances in SNB practice which have the potential to change the standard management for patients with early HNSCC.Keywords Sentinel node biopsy Á Freehand SPECT Á Head and neck squamous cell carcinoma Á Cervical metastasis Á Guided intraoperative scintigraphic tumour targeting (GOSTT)

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“…In prospective studies, it was found that, compared with a gamma probe, fhSPECT improved SLN identification rates in melanoma and breast cancer patients [53,57,58]. Detecting gamma emission from different angles increased the sensitivity and enabled the detection of SLNs containing only a small amount of radiotracer, deep-lying nodes, and SLNs overlaid by fatty tissue (e.g., in obese patients) [32,57,58]. Based on these promising results, the technology was transferred to the complex HN area [54,59].…”

Section: Toward Intraoperative 3d Imagingmentioning

confidence: 99%

New technologies in radioguided surgery in complex anatomic areas

Bluemel

Herrmann

2016

Clin Transl Imaging

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Sentinel lymph node biopsy (SLNB) is the most common radioguided surgery procedure and standard of care for lymph node staging in clinically node-negative patients with melanoma and breast cancer. While SLNB has also emerged as a potential alternative to lymph node dissection for staging in patients with other solid malignancies, its use for this purpose has to date not been widely accepted owing to technical limitations in complex anatomic areas such as the head and neck and the pelvic region. However, new technologies have recently been developed to overcome these limitations. This review focuses on the new technologies that improve SLN localization in complex anatomic areas, including new diagnostic tracers ( 99m Tc-tilmanocept and hybrid tracers), preoperative SPECT/CT imaging, and scintigraphic threedimensional intraoperative imaging techniques.

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Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma

Cited by 50 publications

References 15 publications

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

Role of intraoperative sentinel node imaging in head and neck cancer

New technologies in radioguided surgery in complex anatomic areas

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