Adherence to human lung microvascular endothelial cells (HMVEC-L) of Plasmodium vivax isolates from Colombia

Salas, Briegel De Las; Segura, Cesar; Pabón, Adriana; Lopes, Stefanie Costa Pinto; Costa, Fábio T. M.; Blair, Silvia

doi:10.1186/1475-2875-12-347

Cited by 40 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regional conflicts often destroy physical infrastructure, collapse health systems and exacerbate the malaria burden [ 21 , 22 ]. In conflict areas, such as KSR2 and KOK, the malaria activities were carried out continually by health workers, even in the setting of physical danger.…”

Section: Discussionmentioning

confidence: 99%

Lessons on malaria control in the ethnic minority regions in Northern Myanmar along the China border, 2007–2014

et al. 2016

View full text Add to dashboard Cite

BackgroundFor many countries where malaria is endemic, the burden of malaria is high in border regions. In ethnic minority areas along the Myanmar-China border, residents have poor access to medical care for diagnosis and treatment, and there have been many malaria outbreaks in such areas. Since 2007, with the support of the Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM), a malaria control project was introduced to reduce the malaria burden in several ethnic minority regions.MethodsA malaria control network was established during the period from 2007 to 2014. Multiple malaria interventions, including diagnosis, treatment, distribution of LLINs and health education, were conducted to improve the accessibility and quality of malaria control services for local residents. Annual cross-sectional surveys were conducted to evaluate intervention coverage and indicators of malaria transmission.ResultsIn ethnic minority regions where a malaria control network was established, both the annual malaria incidence (19.1 per thousand per year, in 2009; 8.7, in 2014) and malaria prevalence (13.6 % in 2008; 0.43 % in 2014) decreased dramatically during the past 5–6 years. A total of 851 393 febrile patients were detected, 202 598 malaria cases (including confirmed cases and suspected cases) were treated, and 759 574 LLINs were delivered to populations at risk. Of households in 2012, 73.9 % had at least one ITNs/LLINs (vs. 28.3 %, in 2008), and 50.7 % of children less than 5 years and 50.3 % of pregnant women slept under LLINs the night prior to their visit. Additionally, malaria knowledge was improved in 68.4 % of residents.ConclusionThere has been great success in improving malaria control in these regions from 2007 to 2014. Malaria burdens have decreased, especially in KOK and WA. The continued maintenance of sustainable malaria control networks in these regions may be a long-term process, due to regional conflicts and the lack of funds, technology, and health workers. Furthermore, information and scientific support from the international community should be offered to these ethnic minority regions to uphold recent achievements.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0191-0) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Lessons on malaria control in the ethnic minority regions in Northern Myanmar along the China border, 2007–2014

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Several host receptors were identified, such as CSA and hyaluronic acid (HA), but not CD36 or thrombospondin. Cytoadherence to ICAM-1 is also shown with P. vivax isolates from the Brazilian MarinMenendez et al 2013) and Colombia Amazon (De las Salas et al 2013), but not with Thai isolates (Chotivanich et al 2012). VIR proteins, encoded by the P. vivax interspersed repeat (vir) genes (reviewed in Fernandez-Becerra et al 2009), seem to be (partly) involved.…”

Section: Endothelial Cytoadherence and Spleen Remodelingmentioning

confidence: 99%

“…Plasmodium vivax-iRBCs are observed in spleen biopsies taken from splenectomized patients with acute P. vivax infections (Lubitz 1949;Machado et al 2012), and possibly also on lung autopsies from deceased P. vivax patients from the Brazilian Amazon region (Lacerda et al 2012;Machado et al 2012). Furthermore, in vitro experiments demonstrated cytoadherence of asexual P. vivax isolates, although to a variable degree, to microvascular ECs derived from human lungs, simian brains, and to placental cryosections, whereas conflicting data are found with human umbilical vein ECs (Udomsanpetch et al 1995;Carvalho et al 2010;Chotivanich et al 2012;De las Salas et al 2013;Marin-Menendez et al 2013). Several host receptors were identified, such as CSA and hyaluronic acid (HA), but not CD36 or thrombospondin.…”

Section: Endothelial Cytoadherence and Spleen Remodelingmentioning

confidence: 99%

The immunological balance between host and parasite in malaria

Deroost

Pham

Opdenakker

et al. 2015

FEMS Microbiology Reviews

114

143

View full text Add to dashboard Cite

One sentence summary: The intricate balance between anti-malarial immunity and parasite virulence factors including immune evasion mechanisms determine the outcome of malaria infections, as imbalances resulting in exaggerated parasite growth, excessive inflammation or the combination of both result in severe pathology. Editor: Christian van Ooij ABSTRACTCoevolution of humans and malaria parasites has generated an intricate balance between the immune system of the host and virulence factors of the parasite, equilibrating maximal parasite transmission with limited host damage. Focusing on the blood stage of the disease, we discuss how the balance between anti-parasite immunity versus immunomodulatory and evasion mechanisms of the parasite may result in parasite clearance or chronic infection without major symptoms, whereas imbalances characterized by excessive parasite growth, exaggerated immune reactions or a combination of both cause severe pathology and death, which is detrimental for both parasite and host. A thorough understanding of the immunological balance of malaria and its relation to other physiological balances in the body is of crucial importance for developing effective interventions to reduce malaria-related morbidity and to diminish fatal outcomes due to severe complications. Therefore, we discuss in this review the detailed mechanisms of anti-malarial immunity, parasite virulence factors including immune evasion mechanisms and pathogenesis. Furthermore, we propose a comprehensive classification of malaria complications according to the different types of imbalances.

show abstract

“…Furthermore, proteins anchored on membranes of infected red blood cell (RBC) such as P. falciparum erythrocyte membrane protein 1 (PfEMP1), expressed by parasites, induce endothelium activation resulting in increased expression of adhesion molecules [38,39] and the activation and adhesion of leukocytes to the microvasculature.…”

Section: Molecular and Cellular Features Of The Malaria-induced Inflamentioning

confidence: 99%

Multiple Organ Dysfunction During Severe Malaria: The Role of the Inflammatory Response

Souza¹,

Pádua²,

Henriques³

2016

Current Topics in Malaria

View full text Add to dashboard Cite

Severe malaria is a systemic illness characterized by the dysfunction of one or more peripheral organs, such as the lungs [acute respiratory distress syndrome (ARDS)] and kidneys [acute kidney injury (AKI)]. Several clinical and experimental studies suggest that features of the inflammatory response are related to the multi-organ dysfunction observed in severe malaria. Our group has been dedicated to studying the roles of proand anti-inflammatory mediators in the multi-organ dysfunction observed in experimental severe malaria, especially in the lungs, kidneys, and brain. Herein, we explore severe malaria as a pathology derived from intense inflammatory responses in different organs and further distinguish and compare these organ-specific inflammatory responses. The pathophysiological mechanism of severe malaria is not fully elucidated; however, it is important to study it as a complex inflammatory response assembled by different actors, each one orchestrating a different mechanism.

show abstract

Adherence to human lung microvascular endothelial cells (HMVEC-L) of Plasmodium vivax isolates from Colombia

Cited by 40 publications

References 30 publications

Lessons on malaria control in the ethnic minority regions in Northern Myanmar along the China border, 2007–2014

Lessons on malaria control in the ethnic minority regions in Northern Myanmar along the China border, 2007–2014

The immunological balance between host and parasite in malaria

Multiple Organ Dysfunction During Severe Malaria: The Role of the Inflammatory Response

Contact Info

Product

Resources

About