“…An elementary consequence of standard enzyme kinetics is that molecules using the same protein may compete with or inhibit each other, in this case each other's transport. This is a simply vast topic, so (notwithstanding earlier critiques of summarizing via the enormous review literature), we here simply point out several useful and recent reviews (from the last 3 years only) that describe in detail the many named and genetically identified transporters that are involved in DDI (Han, 2011; Kido et al, 2011; Klatt et al, 2011; König, 2011; Maeda et al, 2011; Marzolini et al, 2011; Müller and Fromm, 2011; Riches et al, 2011; Shitara, 2011; Zhang et al, 2011b; Bi et al, 2012; Elsby et al, 2012; Feng et al, 2012, 2013, 2014; Fromm, 2012; Grandvuinet et al, 2012; Karlgren et al, 2012; Keogh, 2012; Lepist and Ray, 2012; Nies et al, 2012; Sissung et al, 2012; Sprowl and Sparreboom, 2012, 2014; Takanohashi et al, 2012; Varma et al, 2012; Yeo et al, 2012, 2013; Yoshida et al, 2012, 2013; Kis et al, 2013; König et al, 2013; Maeda and Sugiyama, 2013; Sugiyama and Steffansen, 2013; Tang et al, 2013; Zamek-Gliszczynski et al, 2013; Goswami et al, 2014; Tannenbaum and Sheehan, 2014; Vildhede et al, 2014). We are not aware of any papers that showed such DDI based on any measured competition for transport via the phospholipid bilayer.…”