Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score

Kwak, Soo Heon; Choi, Sung Hee; Kim, Kyunga; Jung, Hye Seung; Cho, Young Min; Lim, Soo; Cho, Nam H.; Kim, Seong Yeon; Park, Kyong Soo; Jang, Hak Chul

doi:10.1007/s00125-013-3059-x

Cited by 49 publications

(58 citation statements)

References 28 publications

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“…Our previous investigation has shown that women with Japanese GDM have beta cell dysfunction irrespective of presence or absence of overweight [25]. Regarding the genetic background, several studies revealed risk variants related to insulin secretion in Korean and Chinese population [36][37][38][39][40][41]. Of the three genetic variants found in this study, two are related to the regulation of insulin secretion (i.e.…”

Section: Discussionsupporting

confidence: 48%

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Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

et al. 2017

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Section: Discussionsupporting

confidence: 48%

“…Since women with GDM are at a high risk of future T2DM, genetic information on GDM would be useful for the T2DM risk classification [38,41]. Further research using a larger cohort is warranted for better understanding the genetics of GDM in Japanese women.…”

Section: Discussionmentioning

confidence: 99%

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

et al. 2017

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“…2) [36]. Kwak et al [58] generated a genetic risk score (GRS) that consists of 48 genetic variants associated with type 2 diabetes and validated that adding GRS to clinical models significantly increased the predictability of postpartum diabetes among 395 Korean women with previous GDM (net reclassification index 0.430, p = 7.0 × 10 –5 ). To our knowledge, no genome-wide association study has been conducted to discover specific genetic variants related to postpartum diabetes in women with previous GDM.…”

Section: Risk Factors For Postparum Diabetesmentioning

confidence: 99%

Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Moon

Kwak

Jang

2017

Korean J Intern Med

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Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold higher risk of developing postpartum diabetes compared with women without GDM. Various risk factors for postpartum diabetes have been identified, including maternal age, glucose levels in pregnancy, family history of diabetes, pre-pregnancy and postpartum body mass index, dietary patterns, physical activity, and breastfeeding. Genetic studies revealed that GDM shares common genetic variants with type 2 diabetes. A number of lifestyle interventional trials that aimed to ameliorate modifiable risk factors, including diet, exercise, and breastfeeding, succeeded in reducing the incidence of postpartum diabetes, weight retention, and other obesity-related morbidities. The present review summarizes the findings of previous studies on the incidence and risk factors of postpartum diabetes and discusses recent lifestyle interventional trials that attempted to prevent postpartum diabetes.

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“…23 Similar findings were reported in a cohort of East Asian women using a 48-locus GRS; adding this GRS increased the C-statistic from 0.741 to 0.775 ( P = 0.02), with a continuous NRI of 0.430, indicative of moderate reclassification compared with the clinical model that included age, BMI, family history of T2DM, blood pressure and fasting levels of glucose and insulin. 24 Thus, including genetic risk in a prediction model could inform T2DM prediction even among populations already known to be at very high risk of developing this condition.…”

Section: Genetic Prediction Of T2dm Riskmentioning

confidence: 99%

Susceptibility to type 2 diabetes mellitus—from genes to prevention

2014

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Knowledge of the genetics of type 2 diabetes mellitus (T2DM) has evolved tremendously over the past few years. Following advances in technology and analytical approaches, collaborative case–control genome-wide association studies have revealed up to 65 loci credibly associated with T2DM. Prospective population studies have demonstrated that aggregated genetic risk scores, so-called because they sum the genetic risk attributed to each locus, can predict incident T2DM among individuals of various age ranges and diverse ethnic backgrounds. With each set of T2DM loci discovered, increasing the number of loci in these scores has improved their predictive ability, although a prediction plateau may already have been reached. The current literature shows that intensive lifestyle interventions are effective for preventing T2DM at any level of genetic risk and might be particularly efficacious among individuals with high genetic susceptibility. By contrast, counselling to inform patients about their personal T2DM genetic risk profiles does not seem to improve motivation or attitudes that lead to positive lifestyle behaviour changes. Future studies should investigate the role of genetics for both T2DM prediction and prevention in young populations in the hope of reducing disease burden for future generations.

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Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score

Abstract: In women with GDM, who are at high risk of diabetes, the wGRS was significantly associated with the future development of diabetes. Furthermore, it improved prediction over clinical risk factors.

Cited by 49 publications

References 28 publications

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus

Susceptibility to type 2 diabetes mellitus—from genes to prevention

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