Selective modulation of MHC class II chaperons by a novel IFN-γ-inducible class II transactivator variant in lung adenocarcinoma A549 cells

Chiu, Bau-Lin; Li, Chia-Hsuan; Chang, Chien‐Chung

doi:10.1016/j.bbrc.2013.09.066

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…MHC class II expression can be changed by some molecules 53–55. CIITA is an important regulating factor for promoting MHC class II expression 56.…”

Section: Mhc Class II Expression and Nsclcmentioning

confidence: 99%

“…In another study, when researchers used IFN-γ to stimulate lung adenocarcinoma cell line and bronchial epithelial cell line, it showed different abundance of a CIITA splice variant in two cell lines and different level of MHC class II on cell membrane. Further analysis found this variant could change the expression of genes encoding chaperons which regulated MHC class II assembly and transportation to reduce the surface expression of MHC class II 53. Retinoblastoma protein (Rb) was also involved in MHC class II expression.…”

Section: Mhc Class II Expression and Nsclcmentioning

confidence: 99%

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<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>

Wang

Zhao

Zhang

et al. 2019

OTT

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Lung cancer is one of the commonest cancers in the world. More than 70% of lung cancer patients are diagnosed with non-small cell lung cancer (NSCLC). Major histocompatibility complex class II (MHC class II), an important component in antigen presenting process, usually expresses on professional antigen presenting cells (APCs), and it can be induced by interferon-γ (IFN-γ). MHC class II can be expressed by NSCLC cells. In NSCLC patients, the expression of MHC class II can be correlated with the outcome of anti-programmed death-1 (anti-PD-1) therapy. This review summarizes MHC class II expression in NSCLC and the correlation between MHC class II and NSCLC diagnosis, prognosis and therapy.

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“…MHC class II expression can be changed by some molecules 53–55. CIITA is an important regulating factor for promoting MHC class II expression 56.…”

Section: Mhc Class II Expression and Nsclcmentioning

confidence: 99%

Section: Mhc Class II Expression and Nsclcmentioning

confidence: 99%

<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>

Wang

Zhao

Zhang

et al. 2019

OTT

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“…In this way, IL-17 promotes neutrophil migration to sites of inflammation and mediates inflammatory responses to enhance the antitumor effects of the body (20). IL-8 is a chemotactic inflammatory factor that plays an important role in maintaining cancer cell self-renewal and resistance to chemotherapy drugs through its regulation of cancer stem cells (21)(22)(23). IL-6, as a multifunctional cytokine derived from activated lymphocytes, monocytes, macrophages, bone marrow cells and certain tumor cells, can induce the synthesis of infection-or injury-induced acute inflammatory proteins resulting from acute phase responses.…”

Section: Introductionmentioning

confidence: 99%

Involvement of soluble B7‑H3 in combination with the serum inflammatory cytokines interleukin‑17, ‑8 and ‑6 in the diagnosis of hepatocellular carcinoma

Wang

et al. 2017

Oncol Lett

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Abstract. Previous studies have demonstrated that B7-H3, and the inflammatory cytokines interleukin (IL)-17, IL-8 and IL-6, are involved in the development of a variety of tumors. The objectives of the present study were: i) To investigate the association between soluble B7-H3 (sB7-H3) and cytokine levels of IL-17, IL-8 and IL-6 in the serum of patients with hepatocellular carcinoma (HCC); and ii) to determine their potential value for use in HCC diagnosis. Serum sB7-H3, IL-17, IL-8 and IL-6 levels in the HCC patients and healthy control subjects were measured using ELISA. The accuracy of each of these biomarkers in HCC diagnosis was compared using a receiver operating characteristic curve and the area under the curve (AUC). A logistic regression model was used to investigate the accuracy of diagnosing HCC when evaluated using combined determinations of sB7-H3, IL-17, IL-8 and IL-6 levels. The data demonstrated that serum levels of sB7-H3, IL-17, IL-8 and IL-6 were significantly increased in HCC patients compared with those in the healthy control group. Serum sB7-H3 levels were positively associated with serum IL-17, whereas serum IL-8 levels were negatively correlated with serum IL-17 levels. The AUC values for sB7-H3, IL-17, IL-8 and IL-6 were 83.2, 65.7, 95.3 and 97.0%, respectively, and indicated that all four biomarkers exhibited a statistically significant capacity for diagnosing HCC. Using the logistic regression model, the AUC value, sensitivity and specificity, as determined for the combination of the four biomarkers, were 99.2, 96.67 and 97.14%, respectively. This was significantly greater than that achieved when any single biomarker was used alone in the logistic regression model to assess their accuracy in HCC diagnosis. The optimum cutoff value of the predicted probability obtained by the combination of sB7-H3, IL-17, IL-8 and IL-6 in the regression model was 0.5745. To conclude, the present study revealed that there exists a positive association between serum sB7-H3 and IL-17 levels in HCC patients. Determinations involving the combination of serum sB7-H3, IL-17, IL-8 and IL-6 levels demonstrate great potential for use in HCC diagnosis.

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“…Exon skipping: In primary cells, two novel splice variants of human CIITA were identified [ 45 ]. One variant CIITAΔE7 is devoid of the entire exon 7, which results in the loss of aa 160–209 in the N-terminal part of P/S/T domain of the CIITA protein.…”

Section: Alternative Splicing and Immune Function Of Nucleotide Bimentioning

confidence: 99%

Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection

Chang

Zhang

2017

IJMS

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Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing provides an important source of transcriptome and proteome complexity through selectively joining different coding elements to form mRNAs, which encode proteins with similar or distinct functions. In mammals, previous studies have shown the role of alternative splicing in regulating the function of the immune system, especially in the regulation of T-cell activation and function. As lower vertebrates, teleost fish mainly rely on a large family of pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs) from various invading pathogens. In this review, we summarize recent advances in our understanding of alternative splicing of piscine PRRs including peptidoglycan recognition proteins (PGRPs), nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) and their downstream signaling molecules, compared to splicing in mammals. We also discuss what is known and unknown about the function of splicing isoforms in the innate immune responses against pathogens infection in mammals and teleost fish. Finally, we highlight the consequences of alternative splicing in the innate immune system and give our view of important directions for future studies.

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Selective modulation of MHC class II chaperons by a novel IFN-γ-inducible class II transactivator variant in lung adenocarcinoma A549 cells

Cited by 4 publications

References 24 publications

<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>

<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>

Involvement of soluble B7‑H3 in combination with the serum inflammatory cytokines interleukin‑17, ‑8 and ‑6 in the diagnosis of hepatocellular carcinoma

Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection

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