Is There a Role for FDG-PET for the Assessment of Treatment Efficacy in Wilms’ Tumor? A Case Report and Literature Review

Provenzi, Massimo; Saettini, Francesco; Conter, Valentino; Chinaglia, D.; Vai, P.; Bruno, Andrea; Cavalleri, Laura; Foglia, Carlo; Giraldi, Eugenia; Collini, Paola; Spreafico, Filippo

doi:10.3109/08880018.2013.832446

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…There are currently no adequate treatment guidelines for adult Wilms' tumor (25). The pediatric regimen, which includes radical nephrectomy and adjuvant chemotherapy, with or without radiotherapy, is recommended for the treatment of the adult counterpart.…”

Section: Discussionmentioning

confidence: 99%

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Wilms' tumor in a 51-year-old patient: An extremely rare case and review of the literature

Jin

et al. 2016

Molecular and Clinical Oncology

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Wilms tumor or nephroblastoma is a common kidney malignant tumor in childhood, accounting for ~5% of all pediatric tumors. At present, reports on Wilms' tumor occurring in adults, particularly at ages >30 years, are extremely rare. The majority of the cases of adult Wilms' tumor are closely associated with chemotherapy. Furthermore, in rare cases, Wilms' tumor is characterized by three classic types of cells, namely blastemal, stromal and epithelial cells. We herein report a case of Wilms' tumor with three classic types of cells on histological examination in a 51 year-old male patient who had received prior chemotherapy. The patient promptly underwent radical nephrectomy and remains alive. A review of previously presented cases of adult Wilms' tumor from PubMed database was also performed.

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Section: Discussionmentioning

confidence: 99%

“…The pediatric regimen, which includes radical nephrectomy and adjuvant chemotherapy, with or without radiotherapy, is recommended for the treatment of the adult counterpart. However, there is limited information available for adult Wilms' tumor treatment if the initial chemotherapy fails or if the tumor recurs (25).…”

Section: Discussionmentioning

confidence: 99%

Wilms' tumor in a 51-year-old patient: An extremely rare case and review of the literature

Jin

et al. 2016

Molecular and Clinical Oncology

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“…While MRI shows promise in the preoperative characterization of WT, there are no studies that look specifically at detection of lymph node invasion with MRI. Moreover, investigations of positron emission tomography (PET)/CT or MRI have focused on characterizing primary WT sites and response to treatment, but not nodal invasion ( 27 , 28 ). As advanced imaging modalities continue to evolve and neoadjuvant chemotherapies are further developed, there is opportunity to investigate image-based staging of WT, especially regarding lymph node invasion.…”

Section: Wtmentioning

confidence: 99%

Lymph node imaging of pediatric renal and suprarenal malignancies

Gold

Sabarwal

Gordhan

et al. 2018

Transl. Androl. Urol

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Pediatric renal and suprarenal cancers are relatively rare malignancies, but are not without significant consequence to both the patient and caretakers. These tumors are often found incidentally and present as large abdominal masses. Standard of care management involves surgical excision of the mass, but contemporary treatment guidelines advocate for use of neoadjuvant or adjuvant chemotherapy for advanced stage disease, such as those cases with lymph node involvement (LNI). However, LNI detection is based primarily on surgical pathology and performing extended lymph node dissection can add significant morbidity to a surgical case. In this review, we focus on the use and performance of imaging modalities to detect LNI in Wilms’ tumor (WT), neuroblastoma, and pediatric renal cell carcinoma (RCC). We report on how imaging impacts management of these cases and the clinical implications of LNI. A literature search was conducted for studies published on imaging-based detection of LNI in pediatric renal and suprarenal cancers. Further review focused on surgical and medical management of those cases with suspected LNI. Current imaging protocols assisting in diagnosis and staging of pediatric renal and suprarenal cancers are generally limited to abdominal ultrasound and cross-sectional imaging, mainly computed tomography (CT). Recent research has investigated the role of more advance modalities, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), in the management of these malignancies. Special consideration must be made for pediatric patients who are more vulnerable to ionizing radiation and have characteristic imaging features different from adult controls. Management of pediatric renal and suprarenal cancers is influenced by LNI, but the rarity of these conditions has limited the volume of clinical research regarding imaging-based staging. As such, standardized criteria for LNI on imaging are lacking. Nevertheless, advanced imaging modalities are being investigated and potentially represent more accurate and safer options.

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