Electrical stimulation to accelerate wound healing

Thakral, Gaurav; LaFontaine, Javier; Najafi, Bijan; Talal, Talal K.; Kim, Paul; Lavery, Lawrence A.

doi:10.3402/dfa.v4i0.22081

Cited by 192 publications

(164 citation statements)

References 54 publications

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“…In addition, NO enhances the transfer of glucose into cells and increases epithelization and collagen storage [39] . Electrical stimulation may also stimulate the migration of various wound-modifying cells including keratinocytes, fibroblasts, macrophages, and neutrophils via various signaling mechanisms [40] . Electrical stimulation is typically administered at 30-Hz frequency, at a pulse every 250 microseconds, and 20-milliampere current, using 5 cm × 5 cm disposable carbonized electrodes, for 30 min three times weekly [41] .…”

Section: Electrotherapy Methodsmentioning

confidence: 99%

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Turan

Ertuğrul

Lipsky

et al. 2015

WJEM

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One of the most common and serious complications of diabetes mellitus is ulceration of the foot. Among persons with diabetes, 12%-25% will present to a healthcare institution for a foot disorder during their lifespan. Despite currently available medical and surgical treatments, these are still the most common diabetes-related cause of hospitalization and of lower extremity amputations. Thus, many adjunctive and complementary treatments have been developed in an attempt to improve outcomes. We herein review the available literature on the effectiveness of several treatments, including superficial and deep heaters, electro-therapy procedures, prophylactic methods, exercise and shoe modifications, on diabetic foot wounds. Overall, although physical therapy modalities seem to be useful in the treatment of diabetic foot wounds, further randomized clinical studies are required.

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Section: Electrotherapy Methodsmentioning

confidence: 99%

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Turan

Ertuğrul

Lipsky

et al. 2015

WJEM

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“…24,91,[94][95][96][97][98][99][100] Most of the authors of these narrative reviews formulate an opinion that there is a strong research support for the use of EST to stimulate wound healing and promote wound closure. 24,94,96,98,99,101 However, some reviewers conclude that research is lacking, conflicting, and/or inconclusive.…”

Section: Narrative Reviewsmentioning

confidence: 99%

“…107 One review addressed the effects of interventions used in the treatment of venous ulcers. 115 Thakral et al actually produced two reviews about VLU treatments; 95,115 however, only one had methods describing an SR process. 115 Unfortunately, the narrative review included more of the available literature, while the SR cited only two out of a possible seven CTs that had been published at the time of the review.…”

mentioning

confidence: 99%

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Houghton¹

2017

CWCMR

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Purpose:The overall objective of this study is to identify and appraise all of the existing clinical research literature that has evaluated the effect of electrical stimulation therapy (EST) on wound healing outcomes in adults with various types of chronic wounds. Methods: A systematic and comprehensive search of four electronic databases and gray literature was carried out, and references included in related review articles were checked. Prospective and controlled clinical trials, systematic reviews (SRs), and meta-analyses that assessed the effects of EST on wound healing outcomes were described and appraised. A total PRISMA score was assigned for each included SR based on criteria included in the assessment of multiple systematic reviews (AMSTAR) measurement tool. The percentage of available research that was identified in the SR was also calculated. Results: Sixty-two clinical research studies involving 2082 patients with pressure ulcers, venous leg ulcers, diabetic foot wounds, and arterial/ischemic wounds, and ulcers of mixed etiology were located. Thirty-three of the studies with 1370 patients compared wound size reduction after EST to a control group. Eighteen reviews that used a systematic approach to identify, select, and evaluate published studies on this topic have yielded conflicting results. Poorer quality SRs with a low total PRISMA score were more likely to yield negative or inconclusive findings. Most of these low-quality SRs had very vague research questions and included less than 50% of the available literature that was known to exist. Results from 22 well-designed randomized clinical trials and 10 high-quality SRs consistently support that EST can stimulate faster wound size reduction and/or produce a greater number of closed wounds compared to a group of similar patients receiving either standard wound care or sham EST. Conclusion: Pooled results from well-conducted SRs provide strong support for the use of EST on various types of chronic wounds and pressure ulcers in particular.

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“…Electrical stimulation offers a safe, affordable, and facile approach for regulating cell behavior and function. 189 Electrical stimulation is a biomimicry tool in tissue regeneration representing bioelectrical signals in the body and has been widely used in wound healing applications 190,191 and in the clinics. 192 Endogenous electric fields naturally arise after wounding and keratinocytes migrate in response to it, leading to wound closure.…”

Section: Biophysical Cuesmentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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Electrical stimulation to accelerate wound healing

Cited by 192 publications

References 54 publications

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

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