Osteogenic potential of a chalcone in a critical-size defect in rat calvaria bone

Ortolan, Xana Raquel; Fenner, Bruna Proiss; Mezadri, Telmo José; Tames, David Rivero; Corrêa, Rogério; Buzzi, Fátima de Campos

doi:10.1016/j.jcms.2013.07.020

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…The previous observations are expected for this type of design, similar to reports in the literature. Some reports mention scarring of fibrous nature with parallel collagen fibers that seem to continue with the periosteum, with a thickness lower than the original bone and with evidence of regeneration in the edges of the preparation area [12,13,14,15].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo

Tenorio

Llano

Valencia

et al. 2019

IJMS

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In the last few years, graphene oxide (GO) has gained considerable importance in scaffold preparation for tissue engineering due to the presence of functional groups that allow the interaction between the extracellular matrix and the components of the cellular membrane. The interaction between GO and chitosan (CS) can not only improve the biomechanical properties of the scaffold but also generate a synergistic effect, facilitating tissue recovery. In vivo studies on GO are scarce; therefore, biocompatibility tests on CS-GO scaffolds and bone regeneration experiments on critical size defects were carried out on Wistar rats. Scaffolds made of CS, CS-GO 0.5%, and CS-GO 1% were prepared and implanted on Wistar rats cranial bones for three months. Scaffold samples were analyzed through histochemistry and scanning electron microscopy. The analysis performed showed reabsorption of the material by phagocytic activity and new bone formation. The CS-GO 0.5% formulation gave the best performance in bone regeneration, with excellent biocompatibility. These results show the potential of this compound for tissue regeneration opening and medical applications.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo

Tenorio

Llano

Valencia

et al. 2019

IJMS

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“…Studies with chalcones have been conducted due to the spectrum of biological activities shown by these substances, such as osteogenic, anti-inflammatory, and antibacterial potential, among others [9][10][11] . Moreover, many clinical trials have shown that these molecules are biocompatible and non-toxic 9,10,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacological studies of various synthetic chalcones have shown osteogenic, antioxidante, chemopreventive, anti-inf lammatory, analgesic and antibacterial potential [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of direct pulp capping with a synthetic chalcone: a preliminary histological study.

Tames¹,

Tanello²,

Carpeggiani³

et al. 2015

J Oral Res

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Abstract:The aim of this study is to evaluate the action of the synthetic chalcone 1-phenyl-3-(4-chlorophenyl)-2-propen-1-one to induce pulp healing in rats. Material and Methods: Sixty lower first molars of male Wistar rats were divided into 3 groups (n=20): control (no treatment); calcium hydroxide and chalcone. After relative isolation, the cavities were prepared using a sterile low-speed ¼ round dental bur. After controlling the hemorrhaging, all the pulp exposures were capped with the capping material, by groups. The cavities were sealed with glass ionomer cement and the repair process was assessed at 21 days of procedure. The data were statistically analyzed using the Fisher exact test (p<0.05). Results: Moderate inflammation was observed in all the experimental groups and significant (p<0.05) reparative dentin (tertiary) formation in the calcium hydroxide and chalcone groups. The chalcone group showed dentinal tubules and a low number of cellular inclusions (p<0.05). Conclusion: The chalcone used in this study indicates potential as an inducer of reparative dentine (tertiary) in a rat model.

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“…Kim et al 15 showed that licochalcone A has osteogenic activity, increasing alkaline phosphatase and calcium levels, interfering with cell differentiation, with a possible induction of the expression levels of BMPs. Moreover, Ortolan et al 16 suggested induction of bone repair by chalcone 1-phenyl-3-(4-chlorophenyl)-2-propen-1-one in the rat critical size calvarial defect, as the wounds treated with this molecule showed complete closure after 45 days of treatment. The aim of this study was to evaluate the osteogenic potential of five synthetic chalcone molecules with different substituents (3,4-Cl; 4-Cl; 4-CH 3 ; 4-OCH 3 , H), in three concentrations (1%, 5% and 10%) on critical rat calvarial defects using Vaseline as a vehicle.…”

Section: -14mentioning

confidence: 99%

“…Thus, the anti-inflammatory property of chalcones as reported by Chen et al 21 may have contributed to the improvement of the bone repair stimulus observed in our study, as in animals treated with chalcones no inflammation signs were observed. Previous studies 16 have shown that a single application of chalcone in rat calvarial defects reduces the critical defect size after 30 days of treatment and promotes complete wound closure after 45 days. In our study, we observed predominantly active osteoblasts on the repair surfaces from neoformed bone in animals treated with chalcones.…”

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confidence: 95%

Osteogenic potential of different chalcones in an in vivo model: A preliminary study.

et al. 2017

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Aim. To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH 3 ; 4-OCH 3 , H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student-Newman-Keuls test and the histological sections were analyzed qualitatively by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p<0.01). Active osteoblasts were observed on the repair surfaces in all groups treated with chalcones. Treatment with the C5 molecule at concentration of a 10% resulted in greater bone neoformation compared to the other molecules, with features of secondary bone observed. Conclusion. The chalcones evidenced a dose-dependent osteogenic potential and C5 was more effective in bone repair.

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Osteogenic potential of a chalcone in a critical-size defect in rat calvaria bone

Cited by 14 publications

References 31 publications

Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo

Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo

Evaluation of direct pulp capping with a synthetic chalcone: a preliminary histological study.

Osteogenic potential of different chalcones in an in vivo model: A preliminary study.

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