Prediction of Early and Late Complications after Oral Mucosal Graft Harvesting: Multivariable Analysis from a Cohort of 553 Consecutive Patients

Barbagli, Guido; Fossati, Nicola; Sansalone, Salvatore; Larcher, Alessandro; Romano, Giuseppe; Dell’Acqua, V.; Guazzoni, G.; Lazzeri, Massimo

doi:10.1016/j.juro.2013.09.006

Cited by 61 publications

(52 citation statements)

References 16 publications

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“…The oral mucosa graft was harvested from the cheek according to our standard technique used on more than 553 patients. [7] The graft was tailored as per individual case. The patient was placed in supine position.…”

Section: Methodsmentioning

confidence: 99%

A novel composite two-stage urethroplasty for complex penile strictures: A multicenter experience

et al. 2017

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Introduction:Complex penile strictures are usually repaired using a two-stage urethroplasty. Buccal mucosal graft (BMG) placed in the first stage can have a significant contraction rate, which may require a subsequent revision surgery. We describe a composite two-stage penile urethroplasty using BMG for patients of complex penile strictures who have some salvageable urethral plate.Methods:Within a multi-institutional cohort, 82 patients underwent a two-stage urethroplasty for complex stricture of the penile urethra. Of these 42 patients who underwent our composite two-stage penile urethroplasty using BMG implanted at the second-stage were included. Patients with genital lichen sclerosus or incomplete clinical records were excluded from this study. The primary outcome of the study was to evaluate stricture-free success rate.Results:Of total 42, 4 patients were lost to follow-up. 42% of stricture etiology was failed hypospadias repair. Mean stricture length was 4.5 cm (range 3–8 cm). Seventeen (44.7%) patients had undergone the previous urethroplasty. At a median follow-up of 44 months, of 38 patients, 34 (89.5%) were successful, and 4 (10.5%) had a recurrence. No patient required revision surgery before the second-stage and required redo buccal graft harvesting for subsequent urethroplasty.Conclusions:The composite two-stage technique in repairing complex penile urethral strictures is a valid and reproducible surgical treatment for complex penile stricture and it may reduce the rate of contraction of the transplanted BMG.

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Section: Methodsmentioning

confidence: 99%

A novel composite two-stage urethroplasty for complex penile strictures: A multicenter experience

et al. 2017

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“…[26][27][28][29] A meta-analysis of a total of 17 series with 1234 patients similarly confirmed greater than 93% success of EPA in the management of bulbar urethral stricture disease. 28 Complications following EPA performance are usually minimal and transient.…”

Section: Anastomotic Techniques Excision With Primary Anastomosis (Epmentioning

confidence: 89%

“…3,33 The most appropriate candidates for vessel-sparing EPA appear to be those with short, proximal bulbar strictures. 29 Performance of vessel-sparing EPA is technically challenging and a significant learning curve is likely required.…”

Section: Vessel/spongiosum-sparing Epa Urethroplastymentioning

confidence: 99%

Urethroplasty for Stricture Disease: Contemporary Techniques and Outcomes

Dugi

Simhan

Morey

2016

Urology

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“…In a retrospective study of oral mucosal graft harvesting, Barbagli et al . found that bilateral graft harvesting in long strictures was a significant predictor of patient dissatisfaction . BEES‐HAUS, an endoscopic tissue engineering‐based cell therapy, has tremendous potential even in recurrent and long strictures.…”

Section: Discussionmentioning

confidence: 99%

Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

2018

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Objectives To describe the feasibility of a novel cell‐based endoscopic technique using buccal epithelium, expanded and encapsulated in a thermoreversible gelation polymer scaffold for the treatment of urethral stricture. Methods Six male patients with bulbar urethral stricture ranging from 2.0 to 3.5 cm in length were included in this pilot study. Autologous buccal epithelial cells from a small buccal mucosal biopsy were isolated, cultured and encapsulated in thermoreversible gelation polymer scaffold, and were implanted at the stricture site after a wide endoscopic urethrotomy. Results All the patients voided well, with a mean peak flow rate of 24 mL/s. Urethroscopy carried out at 6 months showed healthy mucosa at the urethrotomy site. However, two of the six patients had recurrence at 18 and 24 months, respectively. Conclusions This endoscopic‐based Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) technique is a promising alternative for the open substitution buccal graft urethroplasty. It is possible to achieve the benefits of open substitution buccal urethroplasty with this endoscopic technique.

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Prediction of Early and Late Complications after Oral Mucosal Graft Harvesting: Multivariable Analysis from a Cohort of 553 Consecutive Patients

Abstract: Harvesting the oral mucosa ovoid graft from a single cheek with closure of the wound is a safe procedure with high rates of patient satisfaction.

Cited by 61 publications

References 16 publications

A novel composite two-stage urethroplasty for complex penile strictures: A multicenter experience

A novel composite two-stage urethroplasty for complex penile strictures: A multicenter experience

Urethroplasty for Stricture Disease: Contemporary Techniques and Outcomes

Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

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