Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population

Prabhu, Nayana; Ho, Adrian W. S.; Wong, Kenneth H. S.; Hutchinson, Paul; Chua, Yen Leong; Kandasamy, Matheswaran; Lee, Dong Hoon; Sivasankar, Baalasubramanian; Kemeny, David M.

doi:10.1128/jvi.01776-13

Cited by 25 publications

(22 citation statements)

References 33 publications

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“…Fas-FasL interactions are crucially important for AICD of T cells, and it is conceivable that the requirement for IFN-g is indirect. However, similar to the findings by Pai et al (2019), IFN-g promotes the deletion of antigen-specific CD8 + T cells and limits the size of the memory cell population in an experimental mouse model for acute influenza virus infection (Prabhu et al, 2013). This demonstrates that IFN-g also has an important role in T cell contraction.…”

supporting

confidence: 76%

Live or Let Die: T Cell Survival in Cancer Immunotherapy

Ruotsalainen

Tüting

2019

Immunity

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supporting

confidence: 76%

Live or Let Die: T Cell Survival in Cancer Immunotherapy

Ruotsalainen

Tüting

2019

Immunity

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“…To understand the nature of the effect, we considered a number of previous studies which had showed that released-active form of antibodies to IFN-g significantly augmented production of IFN-g in both humans and animals [Sherstoboev et al, 2003;Tarasov and Dugina, 2008;Epstein, 2009;Obraztsova et al, 2009;Zhavbert and Dugina, 2013]. Generally, IFN-g plays an important role in the recovery from flu infection by helping to eliminate the virus [Wiley et al, 2001;Bruder et al, 2006;Prabhu et al, 2013;Killip et al, 2015] which means that the regulation of IFN-g level is among the most limiting factors for antiviral host response [Khoufache et al, 2009]. It has been established that AC's influence on the interferon system involves triggering the mechanisms of innate and acquired immunity thus providing the antiviral and immunomodulatory effects, stimulation of the host's defense mechanisms against the virus that is indicative of its pharmacological activity [Epstein, 2009;Tarasov et al, 2012;Epstein, 2013;Zhavbert and Dugina, 2013; Gavrilova and Tarasov, 2014]; which is important in cases of recurrent influenza infection [Wiley et al, 2001;Bruder et al, 2006;Prabhu et al, 2013].…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent antiviral activity of released-active form of antibodies to interferon-gamma against influenza A/California/07/09(H1N1) in murine model

Don

Emelyanova

Yakovleva³

et al. 2016

J. Med. Virol.

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The assessment of dose-response is an essential part of drug development in terms of the determination of a drug's effective dose, finding the safety endpoint, estimation of the pharmacokinetic profile, and even validation of drug activity, especially for therapeutic agents with a principally novel mechanism of action. Drugs based on released-active forms of antibodies are a good example of such a target. In this study, the efficacy of the antiviral drug Anaferon for children (released-active form of antibodies to interferon-gamma) was tested in a dose-dependent manner (at doses of 0.13, 0.2, 0.4, 0.8 ml/mouse/day) in a murine model of acute pneumonia induced by influenza virus pandemic strain A/California/07/09 (H1N1). Administration of the drug at the two highest doses led to: a reduction in the virus infectious titer in lung tissue up to 4.2 lgEID50/20 mg of tissue; infected animals' life prolongation up to 6.7 days; an increase in the survival rate of up to 40% and a decrease in morphological signs of inflammation when compared to the control animals. In this study, the dose-response effect of Anaferon for Children was demonstrated on mice for the first time. This finding is especially important for drugs with a principally novel mechanism of action like drugs based on released-active forms of antibodies. J. Med. Virol. 89:759-766, 2017. © 2016 Wiley Periodicals, Inc.

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“…Previously, our group described a CD4 conventional T cell lost following immunotherapy treatment with agonistic CD40 and IL2 that was associated with IFNγ-dependent upregulation of PDL1 (37, 38), IFNγ was also showed to negatively regulate influenza virus-specific CD8 T cell responses (39). It is possible that IL2 dependent IFNγ production can lead to immune cell loss following treatment cessation.…”

Section: Discussionmentioning

confidence: 99%

Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells

Bouchlaka

Sckisel

Sungur

et al. 2014

The Journal of Immunology

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Due to increasing interest in the removal of immunosuppressive pathways in cancer, the combination of IL2 with antibodies to neutralize TGFβ, a potent immunosuppressive cytokine, was assessed. Combination immunotherapy resulted in significantly greater anti-tumor effects. These were correlated with significant increases in the numbers and functionality of NK cells, NK progenitors and activated CD8 T cells resulting in the observed anti-tumor effects. Combination immunotherapy was also accompanied with lesser toxicities than IL2 therapy alone. Additionally, we observed a dual competition between NK and activated CD8 T cells such that after immunotherapy, the depletion of either effector population resulted in the increased total expansion of the other population and compensatory anti-tumor effects. This study demonstrates the efficacy of this combination immunotherapeutic regimen as a promising cancer therapy and illustrates the existence of potent competitive regulatory pathways between NK and CD8 T cells in response to systemic activation.

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Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population

Cited by 25 publications

References 33 publications

Live or Let Die: T Cell Survival in Cancer Immunotherapy

Live or Let Die: T Cell Survival in Cancer Immunotherapy

Dose-dependent antiviral activity of released-active form of antibodies to interferon-gamma against influenza A/California/07/09(H1N1) in murine model

Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells

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