“Is bipolar disorder an endocrine condition?” Glucose abnormalities in bipolar disorder

García-Rizo, Clemente; Kirkpatrick, Brian; Fernández-Egea, Emilio; Oliveira, Cristina; Meseguer, Ana; Grande, Íria; Undurraga, Juan; Vieta, Eduard; Bernardo, Miquel

doi:10.1111/acps.12194

Cited by 16 publications

(13 citation statements)

References 7 publications

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“…Increased 2HG levels in first episode patients with non-affective psychosis, bipolar disorder and major depressive disorder have been separately described (Fernandez-Egea et al, 2009b; Garcia-Rizo et al, 2014b, 2012). However, the normal values found in adjustment disorder patients are contradictory with what expected from studies in post traumatic stress disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Later epidemiological studies reflected a high prevalence of T2DM in schizophrenia (Mitchell et al, 2013), bipolar disorder (Calkin et al, 2013) or major depressive disorder (Roy and Lloyd, 2012) although those results might have been confounded by treatment. However, research in treatment-naïve patients found metabolic abnormalities at the onset of mental disorder, in non-affective psychosis (Fernandez-Egea et al, 2009a; Ryan et al, 2003; Saddichha et al, 2008; Spelman et al, 2007) as well as bipolar (Garcia-Rizo et al, 2014b) or major depression disorder (Garcia-Rizo et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway

García-Rizo

Kirkpatrick

Fernández-Egea

et al. 2016

Psychoneuroendocrinology

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OBJECTIVE Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role. MATERIAL AND METHODS We compared a two hour glucose load in naïve patients at the onset of a serious mental illness (N=102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N=17) and matched controls (N=98). RESULTS Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [±Standard Deviation] were: for schizophrenia and related disorders 106.51 mg/dL [±32.0], for bipolar disorder 118.33 mg/dL [±34.3], for major depressive disorder 107.42 mg/dL [±34.5], for adjustment disorder 79.06 mg/dL[±24.4] and for the control group 82.11 mg/dL [±23.3] (p<0.001). CONCLUSIONS Our results reflect an abnormal metabolic pathway at the onset of the disease before any pharmacological treatment or other confounding factors might have taken place. Our results suggest a similar glycemic pathway in serious mental illnesses and the subsequent need of primary and secondary prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway

García-Rizo

Kirkpatrick

Fernández-Egea

et al. 2016

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…They found that after that intervention, patients improved their weight, blood/serum cholesterol and triglycerides levels, as well as depressive symptoms and functioning. In addition, there is evidence that bipolar disorder is related to metabolic abnormalities which could reflect a higher "allostatic load" in these patients and thus, a higher burden or more severe form of disease (García-Rizo et al, 2014;Vieta et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Predictors of functional outcome after a manic episode

Bonnín¹,

Reinares²,

Hidalgo‐Mazzei³

et al. 2015

Journal of Affective Disorders

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“…In between those, glycemic abnormalities are a consistent finding, recalling pre-antipsychotic studies that highlighted an unexpected relationship between manic-depressive illness and glucose metabolism (12). Although to date, we have conducted the only one study in drug-naïve bipolar subjects, describing glucose abnormalities through an increased 2-h glucose load (23). Indeed, altered glucose homeostasis (insulin dysfunction) has been theorized as the reason of the increased amount of medical comorbidities found in bipolar disorder (24).…”

mentioning

confidence: 99%

“…Glycemic abnormalities have been described to have a familial background besides being associated with factors such as obesity and sedentary lifestyle. However, studies in young naïve psychiatric patients, well matched with regard to body mass index and other potentially confounding factors (14, 21, 23), may suggest that their impaired glucose tolerance is related to the same early environmental factors that led to their psychiatric disorder.…”

mentioning

confidence: 99%