New CoreValve Evolut 23mm Technology for Treatment of Degenerated Bioprosthesis

Zavalloni, Dennis; Benedictis, Mauro De; Pagnotta, Paolo; Scrocca, Innocenzo; Presbitero, Patrizia

doi:10.1016/j.hlc.2013.08.002

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Well-controlled experiments in which porosity on the PEEK surface is produced using various chemical methods show that small differences in resulting surface properties can alter osteoblast growth and differentiation as well as osseointegration. 26 Although these studies demonstrate the value of surface roughness in osteogenic effects of PEEK materials, few reports have directly compared responses to PEEK with responses to Ti6Al4V. Even those studies that have examined responses to PEEK and Ti6Al4V have not assessed effects on immune modulation.…”

Section: Discussionmentioning

confidence: 99%

Implant Materials Generate Different Peri-implant Inflammatory Factors

Olivares-Navarrete

Hyzy

Slosar

et al. 2015

Spine

138

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Study Design An in vitro study examining factors produced by human mesenchymal stem cells (MSCs) on spine implant materials. Objective The aim of this study was to examine if the inflammatory microenvironment generated by cells on titanium-aluminum-vanadium (Ti-alloy, TiAlV) surfaces is affected by surface microtexture and if it differs from that generated on poly(ether ether ketone) (PEEK). Summary of Background Data Histologically, implants fabricated from PEEK have a fibrous connective tissue surface interface whereas Ti-alloy implants demonstrate close approximation with surrounding bone. Ti-alloy surfaces with complex micron/submicron scale roughness promote osteoblastic differentiation and foster a specific cellular environment that favors bone formation while PEEK favors fibrous tissue formation. Methods Human MSCs were cultured on tissue culture polystyrene (TCPS), PEEK, smooth TiAlV, or macro/micro/nano-textured rough TiAlV (mmnTiAlV) disks. Osteoblastic differentiation and secreted inflammatory interleukins were assessed after seven days. Fold changes in mRNAs for inflammation, necrosis, DNA damage, or apoptosis with respect to TCPS were measured by low-density PCR array. Data were analyzed by ANOVA followed by Student’s t-test with post hoc analysis. Results Cells on PEEK up-regulated mRNAs for chemokine ligand-2 (CCL2), interleukin (IL) 1β, IL6, IL8, and tumor necrosis factor (TNF). Cells grown on the mmnTiAlV had an 8-fold reduction in mRNAs for toll-like receptor-4. Cells grown on mmnTiAlV had reduced levels of pro-inflammatory interleukins. Cells on PEEK had higher mRNAs for factors strongly associated with cell death/apoptosis, while cells on mmnTiAlV exhibited reduced cytokine factor levels. All results were significant (p<0.05). Conclusions These results suggest that fibrous tissue around PEEK implants may be due to several factors: reduced osteoblastic differentiation of progenitor cells and production of an inflammatory environment that favors cell death via apoptosis and necrosis. Ti alloy surfaces with complex macro/micro/nano-scale roughness promote osteoblastic differentiation and foster a specific cellular environment that favors bone formation.

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Section: Discussionmentioning

confidence: 99%

Implant Materials Generate Different Peri-implant Inflammatory Factors

Olivares-Navarrete

Hyzy

Slosar

et al. 2015

Spine

138

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“…It is indicated for small (18-20 mm) aortic annuli and designed to be fully repositionable, resheathable and recapturable [16]. It has a Conformité Européenne (CE) mark for valve-in-valve implantations since 2013 and was previously described for this indication in case reports [17,18].…”

Section: Medtronic Corevalve Evolute / Evolute Rmentioning

confidence: 99%

Update on New Devices for Transcatheter Aortic Valve Replacement

Abramowitz¹,

Chakravarty²,

Jilaihawi³

et al. 2015

jshd

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Transcatheter aortic valve replacement (TAVR) for severe symptomatic aortic stenosis is the standard of care in inoperable patients and an alternative to surgical aortic valve replacement in high-risk operable patients. Several issues affecting outcomes with implantation of the first-generation TAVR devices remain unresolved, including neurological and vascular complications, atrioventicular conduction abnormalities, and paravalvular aortic regurgitation. New-generation TAVR devices are currently in different stages of clinical development and evaluation. Modifications in the new devices include the ability to reposition the valve before final deployment, features to reduce paravalvular leakage, lower-profile delivery systems, and cerebral protection devices. The purpose of this manuscript is to give an update on the new-generation transcatheter valvular technologies, focusing on the unique features and describing the initial clinical experience for each device.

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