Pentacyclic Triterpenes from &lt;b&gt;&lt;i&gt;Terminalia arjuna&lt;/i&gt;&lt;/b&gt; Show Multiple Benefits on Aged and Dry Skin

Farwick, Mike; Köhler, Theresa; Schild, J.; Mentel, Matthias; Maczkiewitz, Ursula; Pagani, V.; Bonfigli, Adriana; Rigano, Luciano A.; Bureik, D.; Gauglitz, Gerd G.

doi:10.1159/000351387

Cited by 19 publications

(11 citation statements)

References 61 publications

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“…In a 2010 US patent the hydration increase of the skin treated with a cosmetic product is attributed to ursolic acid [44]. Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production thus modifying the parameters of skin [45].…”

Section: Resultsmentioning

confidence: 99%

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

et al. 2014

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Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. The coefficient of drug interaction (CDI) was used to characterize the interactions as synergism, additivity or antagonism. Our results revealed an increased antitumor activity for the mixture of the two triterpenic acids, both single and in complex with cyclodextrin, thus proving their complementary biologic activities.

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Section: Resultsmentioning

confidence: 99%

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

et al. 2014

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“…Although monolayer cultures of keratinocytes and fibroblasts and reconstituted human epidermis have been used for this purpose [38], a culture model which resembles the three-dimensional structure of the skin in vivo is needed. We therefore introduced a sophisticated coculture system of skin keratinocytes and fibroblasts in this study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Takatori

Iwamoto

et al. 2015

Skin Pharmacol Physiol

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Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a collagen-derived dipeptide, on gene expression in a coculture of mouse skin keratinocytes and fibroblasts. Using microarray analysis, we found that oral administration of CP to hairless mice for 6 weeks induced increased expression of Krtap and Krt genes in the skin. Annotation analysis using DAVID revealed that a group of the up-regulated genes, Gprc5d, Sprr2a1, Krt27 and Krtap16-7, is associated with the development of the epidermis and the hair cycle. In addition, the presence of Pro-Hyp (200 μM) induced an increase in the expression of Krtap16-7, Krtap15, Krtap14 and Krtap8-2 in keratinocytes in coculture, partially resembling the in vivo result. The Pro-Hyp-induced up-regulation of these genes was not observed when keratinocytes were cultured without fibroblasts, suggesting that the presence of fibroblasts is essential for the effects of Pro-Hyp. Our study presents new insights into the effects of CP on the skin, which might link to the hair cycle.

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“…Further ten articles were included reporting 12 studies ( Angelova-Fischer et al, 2018 ;Behm et al, 2015 ;Blaak et al, 2015 ;Brooks et al, 2017 ;Farwick et al, 2014 ;Narbutt et al, 2016 ;Paulela et al, 2018 ;Schoonhoven et al, 2015 ;Elewa et al, 2012 ;Roure et al, 2012 ) for maintaining and improvement of skin barrier integrity ( Table 3 ). The included studies for dry skin prevention and treatment comprised 21 RCTs.…”

Section: Study Characteristics and Risk Of Biasmentioning

confidence: 99%

Maintaining skin integrity in the aged: a systematic review

2013

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Ageing is associated with structural and functional changes of the skin that result in increased vulnerability. The aim of this systematic review is to synthesize empirical evidence about the efficacy and effectiveness of basic skin care interventions for maintaining skin integrity in the aged. The databases Medline, EMBASE, CINAHL (1990-2012), Scopus, SCI (February 2013) and reference lists were searched. Inclusion criteria were primary intervention studies using skin care products in physiologically aged skin (lower age limit 50 years). Study and sample characteristics, interventions and outcomes were extracted. The methodological quality was assessed and a level of evidence was assigned. From 1535 screened articles 188 were read in full text. From these, 33 articles were included reporting results on treating dry skin conditions, and preventing incontinence-associated dermatitis and superficial ulcerations. Most studies had lower levels of evidence of 3 or 4. Skin-cleansing products containing syndets or amphoteric surfactants compared with standard soap and water washing improved skin dryness and demonstrated skin-protecting effects. Moisturizers containing humectants consistently showed statistically significant improvements in skin dryness. Skin barrier products containing occlusives reduced the occurrence of skin injuries compared with standard or no treatment. Owing to methodological limitations the current evidence base for basic skin care in the aged is weak. Using low-irritating cleansing products and humectant- or occlusive-containing moisturizers seems to be the best strategy for maintaining the skin barrier function and integrity. We know little about the effects of cleansing regimens and about the benefits of moisturizers when compared with each other.

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Pentacyclic Triterpenes from <b><i>Terminalia arjuna</i></b> Show Multiple Benefits on Aged and Dry Skin

Cited by 19 publications

References 61 publications

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Maintaining skin integrity in the aged: a systematic review

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