Comparison of arterial versus venous parameters of Rotational thromboelastometry and multiple platelet function analyzer: Results of a pilot study

Oswald, Elgar; Finsterwalder, Thomas; Innerhofer, Nicole; Haas, Thorsten; Mittermayr, Markus; Strohmaier, Susanne; Innerhofer, Petra

doi:10.3109/00365513.2013.818707

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…The mean percentage errors between the matched sample for CS, FCS, and PCS were 0.63%, 0.81%, and 0.02%, respectively. Previous studies have reported conflicting results with respect to stiffness-based parameters of the TEG and ROTEM systems, with some investigators showing good agreement and linear correlation, 13 , 14 whereas others have found statistically significant differences. 11 , 16 …”

Section: Discussionmentioning

confidence: 94%

“…Also in this case, venous R times were shorter than arterial R times. Oswald et al 13 also found a statistically significant difference for the ROTEM delta’s INTEM CT (assay activated via ellagic acid) with moderate correlation between arterial and venous samples ( r value of 0.519).…”

Section: Discussionmentioning

confidence: 95%

“… 12 Another study showed little to no differences in the ROTEM delta parameters between arterial and venous samples obtained from orthopedic surgery patients; arterial and venous variables showed strong to very strong correlation except for CT, which showed only moderate correlation between the 2 sample types. 13 Recently, a study from Tuovila et al with patients undergoing a broad range of surgical procedures reported differences of up to 19% for clot time and up to 5.5 % for maximum clot amplitude on paired sets of arterial and venous samples on the TEG 5000. 14 …”

mentioning

confidence: 99%

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Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System

Groves

Winegar

Fernández

et al. 2019

Journal of Cardiothoracic and Vascular Anesthesia

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Objective: Perioperative coagulation testing often is performed with arterial samples even though device reference ranges typically are established in venous samples. Although limited studies exist comparing coagulation parameters across sampling sites, viscoelastic testing devices have demonstrated some differences. The objective of this study was to compare coagulation parameters determined using the Quantra System for venous and arterial samples. Design: Prospective, observational study. Setting: Tertiary care university hospital. Participants: The study comprised 30 adult patients undergoing cardiac surgery. Interventions: Paired arterial and venous samples were obtained at 2 of the following time points: baseline, during bypass, or after protamine reversal of heparin. Quantra measurements included Clot Time (CT), Heparinase Clot Time (CTH), Clot Time Ratio (CTR), Clot Stiffness (CS), and Fibrinogen (FCS) and Platelet (PCS) Contributions to clot stiffness. Measurements and Main Results: The relationship and agreement between matched data pairs were established and statistical analysis was performed via paired t tests. CTR, CS, FCS, and PCS were unaffected by the sampling site, whereas CT and CTH demonstrated statistically significant differences between arterial and venous samples (p < 0.001). Arterial clot times were prolonged relative to the venous ones with a mean percent error of 14.2 % and 11.9 %, respectively. These results are in general agreement with those reported for other viscoelastic testing devices. Conclusions: This study demonstrates that Quantra clot stiffness-based parameters (CS, FCS, PCS) are unaffected by sampling site, whereas the clot time parameters (CT and CTH) show good correlation in the presence of a bias. CTR, a ratio of CT and CTH, also is unaffected.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System

Groves

Winegar

Fernández

et al. 2019

Journal of Cardiothoracic and Vascular Anesthesia

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“…This also gives further evidence that scientific measurements of clot microstructure, such as d f which is a structural marker of the end point of the coagulation system, may give a more meaningful and accurate marker of haemostasis in either arterial or venous blood. [8][9][10] The limitations of the study were it being a single-centre observational study and further studies are required to assess its potential.…”

Section: Discussionmentioning

confidence: 99%

A comparative study into the effects of venous and arterial blood on clot microstructure in critically unwell patients. Assessment of the diagnostic potential of a biomarker of haemostasis

Pillai

Evans

Davies

et al. 2021

Journal of the Intensive Care Society

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Blood for coagulation analysis can be sampled from the arterial or venous system in intensive care units (ICU). The determination of clot microstructure and strength by fractal analysis (d f) gives valuable information in a range of vascular haemostatic disease and sepsis. We aimed to determine if d f could be measured equally and comparatively in arterial or venous blood, and 45 critically ill patients in an ICU were recruited. d f was found to be readily measured in arterial blood with results comparable to those in venous blood and that add value of d f as a potential marker of haemostasis in these patients.

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“…Venous and arterial variability in VHA parameters was studied using the INTEM, EXTEM, and FIBTEM assays of ROTEM in 52 patients at the time of arterial line insertion, intraoperatively, and postoperatively. There was no change in any parameters between venous and arterial samples, demonstrating that VHA assessment was consistent across both venous and arterial blood sampling [ 75 ].…”

Section: Viscoelastic Hemostatic Assays In Orthopedic Surgerymentioning

confidence: 99%

Viscoelastic Hemostatic Assays for Orthopedic Trauma and Elective Procedures

Mamczak

Speybroeck

Stillson

et al. 2022

JCM

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The application of viscoelastic hemostatic assays (VHAs) (e.g., thromboelastography (TEG) and rotational thromboelastometry (ROTEM)) in orthopedics is in its relative infancy when compared with other surgical fields. Fortunately, several recent studies describe the emerging use of VHAs to quickly and reliably analyze the real-time coagulation and fibrinolytic status in both orthopedic trauma and elective orthopedic surgery. Trauma-induced coagulopathy—a spectrum of abnormal coagulation phenotypes including clotting factor depletion, inadequate thrombin generation, platelet dysfunction, and dysregulated fibrinolysis—remains a potentially fatal complication in severely injured and/or hemorrhaging patients whose timely diagnosis and management are aided by the use of VHAs. Furthermore, VHAs are an invaluable compliment to common coagulation tests by facilitating the detection of hypercoagulable states commonly associated with orthopedic injury and postoperative status. The use of VHAs to identify hypercoagulability allows for an accurate venous thromboembolism (VTE) risk assessment and monitoring of VTE prophylaxis. Until now, the data have been insufficient to permit an individualized approach with regard to dosing and duration for VTE thromboprophylaxis. By incorporating VHAs into routine practice, orthopedic surgeons will be better equipped to diagnose and treat the complete spectrum of coagulation abnormalities faced by orthopedic patients. This work serves as an educational primer and up-to-date review of the current literature on the use of VHAs in orthopedic surgery.

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Comparison of arterial versus venous parameters of Rotational thromboelastometry and multiple platelet function analyzer: Results of a pilot study

Abstract: The observed differences between arterial and venous results were within the range of variability of the methods reported for venous blood. Pathological values that might be clinically relevant could be detected at similar rates regardless of the sampling site.

Cited by 9 publications

References 19 publications

Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System

Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System

A comparative study into the effects of venous and arterial blood on clot microstructure in critically unwell patients. Assessment of the diagnostic potential of a biomarker of haemostasis

Viscoelastic Hemostatic Assays for Orthopedic Trauma and Elective Procedures

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