24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain

Clark, Kristine; Sebastianelli, Wayne J.; Flechsenhar, K.; Aukermann, Douglas F.; Meza, Felix; Millard, Roberta; Deitch, John; Sherbondy, Paul S.; Albert, A.

doi:10.1185/030079908x291967

Cited by 123 publications

(120 citation statements)

References 5 publications

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“…A 24-week prospective, randomized, placebocontrolled, double blind study was conducted with 147 healthy college athletes complaining of arthralgia [20]. The students were randomized to receive either placebo or 10 g of collagen hydrolysate daily for the duration of the study.…”

Section: Discussionmentioning

confidence: 99%

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

Gonçalves¹

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We report three cases of OCL in athletes, which were diagnosed and followed with magnetic resonance imaging (MRI) scan after multidisciplinary treatment including nutritional supplementation with Fortigel® a specific collagen hydrolysate that contains bioactive collagen peptides. A literature review on the role of collagen hydrolysate and its nutritional aspect in supporting the regeneration of articular cartilage is also presented. Conclusion: MRI images of patients assessed in this study depict the recovery of the articular surfaces after the treatment. Also, studies in athletes presenting joint pain but otherwise not diagnosed with osteoarthritis or other osteoarticular diseases have demonstrated the beneficial effects of CH intake. IJCRI publishes

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Section: Discussionmentioning

confidence: 99%

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

Gonçalves¹

2017

IJCRI

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“…The hydrolyzed collagens have been recognized as safe food ingredients [14,15]. Clinical studies revealed that the hydrolyzed collagens can not only improve joint function [16] and reduce joint pain [17], but also relieve symptoms of osteoporosis. By feeding ovariectomized rats with oral collagen peptides, Nomura, et al reported that collagens can increase rat bone density and improve the spine function.…”

Section: Discussionmentioning

confidence: 99%

“…Collagen peptides, the collagen hydrolysates, are produced by hydrolysis of polypeptides from gelatin mixture. Because they can be used as potential oral supplements for bone and joint tissues, and they can also enhance the bone density of ovariectomized rats, collagen peptides draw wide attention of researchers [4]. It is reported that the bioactivities of collagen peptides are not only related to the source of collagen, but also correlated with their molecular weight, such as antioxidant activities found in active peptides derived from fish or squid skin gelatins [5].…”

Section: Introductionmentioning

confidence: 99%

The effect of different molecular weight collagen peptides on MC3T3-E1 cells differentiation

Si¹,

Qin²,

Zhang

et al. 2015

BME

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Abstract. Our study aimed at investigating the effect of different molecular weight bovine collagen peptides, namely CH878, CH1370, CH2900, and CH7747 on the differentiation of MC3T3-E1 cells. Osteogenic differentiation of MC3T3-E1 cells was assessed by a series of specific assays, after culturing of cells in the presence of collagen peptides. Alkaline phosphatase activity (ALP) was evaluated by NBT/BCIP staining. Osteocalcin expression was determined by a radioimmunology method. Mineralization was quantified by Alizarin Red staining. ALP staining results demonstrated that the ALP staining of cells after culture in the presence of collagen peptides were significantly higher than the control group (P 0.05), indicating the promotion of ALP activity in MC3T3-E1 cells by these peptides. Radioimmunology results demonstrated that collagen peptides groups were all significantly higher than the control group (P 0.01). Alizarin Red staining results demonstrated that CH1370, CH2900, and CH7747 significantly promoted the formation of mineralized bone matrix. We therefore conclude that CH1370, CH2900, and CH7747 play an active role in the differentiation of MC3T3-E1 cells. Based on the above results, we provide molecular basis for further development of collagens with different molecular weight for the prevention and treatment of osteoporosis.

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“…In particular, the applicant claimed proprietary rights for two of the studies provided for the substantiation of the claim (Clark et al, 2008;Flechsenhar and Alf, 2005).…”

Section: Information Provided By the Applicantmentioning

confidence: 99%

“…In a randomised, double-blind, placebo-controlled trial, 147 (72 male, 75 female) active student athletes, mean age 20 years and who complained about physical activity-related joint discomfort because of joint stress, injury, surgical outcome, or trauma, received 10 g collagen hydrolysate per day or placebo for 24 weeks (Clark et al, 2008;Gelita AG, 2007, unpublished). Potential subjects were excluded if they had an acute injury of a joint or an inflammatory process, ingested glucosamine, chondroitin, or other nutritional supplements indicated for treatment of joint pain and osteoarthritis or who, from a clinical perspective, were considered likely to increase their dose of analgesic medication during the 24-week study because of severe arthralgia.…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to collagen hydrolysate and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Products¹

2011

EFS2

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Following an application from Gelita AG, submitted via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to collagen hydrolysate and maintenance of joint health. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence and including a request for the protection of proprietary data. The food constituent that is the subject of the health claim is collagen hydrolysate. The Panel considers that the collagen hydrolysate is sufficiently characterised. The claimed effect is “maintenance of joint health”. The target population as proposed by the applicant is physically active people. The Panel considers that the maintenance of joints is a beneficial physiological effect. The applicant provided one narrative review, three intervention studies in humans, one animal study, two in vitro studies, and two bioavailability studies as pertinent to the claim. The narrative review did not contain any primary data which were pertinent to the claim. One of the human studies was conducted in patients while another study was not controlled and no scientific conclusions could be drawn from these studies for the substantiation of the claimed effect. One trial in 147 active student athletes evaluated a total of 15 parameters related to joint pain/discomfort. There were no significant differences between groups for any endpoint when significance levels were adjusted for multiple comparisons. In weighing the evidence, the Panel took into account that one study in physically active humans did not show an effect of collagen hydrolysate on joint discomfort, and that studies in animals and in vitro do not predict an effect of collagen hydrolysate on maintenance of joints in humans in vivo. The Panel concludes that a cause and effect relationship has not been established between the consumption of collagen hydrolysate and maintenance of joints.

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24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain

Cited by 123 publications

References 5 publications

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

The effect of different molecular weight collagen peptides on MC3T3-E1 cells differentiation

Scientific Opinion on the substantiation of a health claim related to collagen hydrolysate and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

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