24. Pankreas-Carcinom. Pathologisch-anatomische Grundlagen

Becker, Volker

doi:10.1007/bf01257511

Cited by 4 publications

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References 5 publications

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“…Eine solche (chronische obstruktive Pankreatitis) fanden Seifert und K16ppel [30] bei 31 von 40 Pankreatektomien wegen Carcinoms, Becker [3] h~ilt die Begleitpankreatitis fiir noch h/iufiger (,,Kein Carcinom ohne chronische Pankreatitis ! Eine dieser liegt darin, da6 besonders kleine und tief liegende Carcinome bei der Biopsie unter Umstfinden nicht erreicht werden und in den Biopsien nur unrepdisentatives Material enthalten ist, insbesondere die das Carcinom umgebende Begleitpankreatitis zu beobachten ist.…”

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Intraoperative Diagnostik des Pankreascarcinoms

Hermanek

1983

Langenbecks Arch Chiv

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Between 1978 and 1981 634 frozen section examinations were performed during 185 operations on patients with pancreatic or periampullary carcinoma. The frozen section findings and the definite reports after paraffin embedding were identical in 97.2% of all examinations. 1.6% of frozen section findings were false negative, 0.2% false positive. The positive predictive value, especially important for the surgeon, was 100% for examinations of the pancreas and the primary tumor and 98.9% for metastases and structures suspicious of metastases. The negative predictive value was 94.3% and 99.6% respectively. Serious complications of pancreatic biopsies were not observed. On 438 pancreatic resection specimens after intraoperative frozen section examination a benign disease was diagnosed between 1971 and 1981. By further work-up after paraffin embedding at another institution a carcinoma was detected surprisingly only in two cases (0.5%). A pancreatic resection based on a false positive frozen section finding was never performed. The results prove that intraoperative frozen section examination is a useful and reliable diagnostic procedure. A review of the recent literature demonstrates as well that similar results cannot be achieved by other methods including intraoperative fine needle aspiration biopsy.

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