24-Hour video EEG in the evaluation of the first unprovoked seizure

Haddad, Naim; Melikyan, Gayane; Alarcón, Gonzalo; Shaheen, Yanal; Siddiqi, Maria; Ali, Elfateh; Mesraoua, Boulenouar; Al-Hail, Hassan; Al-Abdulghani, Abdulaziz; Alrabi, Abdulraheem; Syamala, Anitha; Kazi, Farhana; Mahfoud, Ziyad

doi:10.1016/j.cnp.2021.02.006

“…In this study, treatment initiation after the first versus the second seizure was not associated with a worse long‐term prognosis [3]. Moreover, several previous large‐scale studies have shown that prior seizures are a risk factor for seizure relapse in NOE [3–5]. Seizure recurrence remained different up to 8 years if patients had experienced previous (untreated) seizures, independent of whether immediate or deferred treatment was offered [3].…”

Section: Introductionmentioning

confidence: 84%

Antiseizure medication ≤48 hours portends better prognosis in new‐onset epilepsy

Ménétré,

De Stefano,

Megevand

et al. 2023

Euro J of Neurology

1

0

View full text Add to dashboard Cite

BackgroundSeveral studies found that patients with new‐onset epilepsy (NOE) have higher seizure recurrence rates if they presented already prior seizures. These observations suggest that timing of antiseizure medication (ASM) is crucial and should be offered immediately after the first seizure. Here, we wanted to assess whether immediate ASM is associated with improved outcome.MethodsSingle‐center study of 1010 patients (≥16 years) who presented with a possible first seizure in the emergency department between 1 March 2010 and 1 March 2017. A comprehensive workup was launched upon arrival, including routine electroencephalography (EEG), brain computed tomography/magnetic resonance imaging, long‐term overnight EEG and specialized consultations. We followed patients for 5 years comparing the relapse rate in patients treated within 48 h to those with treatment >48 h.ResultsA total of 487 patients were diagnosed with NOE. Of the 416 patients (162 female, age: 54.6 ± 21.1 years) for whom the treatment start could be retrieved, 80% (333/416) were treated within 48 h. The recurrence rate after immediate treatment (32%; 107/333) was significantly lower than in patients treated later (56.6%; 47/83; p < 0.001). For patients for whom a complete 5‐year‐follow‐up was available (N = 297, 123 female), those treated ≤48 h (N = 228; 76.8%) had a significantly higher chance of remaining seizure‐free compared with patients treated later (N = 69; 23.2%; p < 0.001).ConclusionsIn this retrospective study, immediate ASM therapy (i.e., within 48 h) was associated with better prognosis up to 5 years after the index event. Prospective studies are required to determine the value of immediate workup and drug therapy in NOE patients.

show abstract

24-Stunden-Video-EEG bei der Bewertung des ersten unprovozierten Anfalls

2021

Klinische Neurophysiologie

0

View full text Add to dashboard Cite

Ein einzelner unprovozierter epileptischer Anfall ist ein häufiges Szenario in der neurologischen Praxis. Zur Entscheidung über den Beginn einer antiepileptischen Medikation muss das Risikos eines Anfallsrezidivs abgeschätzt werden. Dafür spielt der Befund im EEG (Elektroenzephalogramm) eine entscheidende Rolle, da das Auftreten von epileptiformen Entladungen (EDs) im EEG das relative Risiko eines Anfallsrezidivs erhöht. Diese Arbeit sollte bewerten, welchen zusätzlichen Vorteil ein 24-Stunden-Elektroenzephalogramm (24h-EEG) nach dem ersten Anfall für die Erkennung epileptiformer Anomalien bringt.

show abstract

24-Stunden-Video-EEG bei der Bewertung des ersten unprovozierten Anfalls

2022

Fortschr Neurol Psychiatr

0

View full text Add to dashboard Cite

Ein einzelner unprovozierter epileptischer Anfall ist ein häufiges Szenario in der neurologischen Praxis. Zur Entscheidung über den Beginn einer antiepileptischen Medikation muss das Risikos eines Anfallsrezidivs abgeschätzt werden. Dafür spielt der Befund im EEG (Elektroenzephalogramm) eine entscheidende Rolle, da das Auftreten von epileptiformen Entladungen (EDs) im EEG das relative Risiko eines Anfallsrezidivs erhöht. Diese Arbeit sollte bewerten, welchen zusätzlichen Vorteil ein 24-Stunden-Elektroenzephalogramm (24h-EEG) nach dem ersten Anfall für die Erkennung epileptiformer Anomalien bringt.

show abstract

24-Hour video EEG in the evaluation of the first unprovoked seizure

Cited by 3 publications

References 30 publications

Antiseizure medication ≤48 hours portends better prognosis in new‐onset epilepsy

Antiseizure medication ≤48 hours portends better prognosis in new‐onset epilepsy

24-Stunden-Video-EEG bei der Bewertung des ersten unprovozierten Anfalls

24-Stunden-Video-EEG bei der Bewertung des ersten unprovozierten Anfalls

Contact Info

Product

Resources

About