24-Hour prophylaxis with octreotide in high-risk patients for post-ERCP pancreatitis: Results of a multicentre, randomized, controlled trial

Testoni, P.A.; Bagnolo, F.; Andriulli, Angelo; Bernasconi, C; Crotta, Sergio; Lella, F.; Lomazzi, A.; Minoli, G.; Negrini, F.; Prada, A.; Toti, G. L.; Zambelli, A.

doi:10.1016/s1590-8658(00)80631-3

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Prevention and Treatment Of Acute Pancreatitis1

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2006

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“…The results varied widely. Several studies have failed to show that somatostatin or octreotide have any benefi cial effect, even when the drug was given before ERCP and up to 20 h later [49][50][51][52][53][54][55] . In one study, there was even an increase in the incidence of pancreatitis, when octreotide was given prophylactically before a diagnostic ERCP [56] .…”

Section: Prevention and Treatment Of Acute Pancreatitismentioning

confidence: 99%

Pharmacological Prevention and Treatment of Acute Pancreatitis: Where Are We Now?

Lankisch

Lerch²

2006

Dig Dis

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Acute pancreatitis is a disease of increasing prevalence, unchanged mortality over many decades, and limited treatment strategies. Progress has been made in developing therapies that reduce the rate of endoscopic retrograde cholangiopancreatography (ERCP)-associated pancreatitis and in preventing infected pancreatic necrosis with intravenous carbapenems. Attempts at reducing pancreatic enzyme output or inhibiting the activity of digestive enzyme proteases have not yielded encouraging results – nor have anti-inflammatory strategies for the treatment of acute pancreatitis been found to be effective so far. Future therapeutic options that are presently being developed or under investigation attempt to restore pancreatic secretory function, interfere with inflammatory pathways in a more effective manner, or inhibit digestive enzyme proteases more selectively.

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