24-Hour Pituitary and Adrenal Hormone Profiles in Chronic Fatigue Syndrome

Giorgio, Annabella Di; Hudson, Marina; Jerjes, Walid K.; Cleare, Anthony J.

doi:10.1097/01.psy.0000161206.55324.8a

Cited by 48 publications

(38 citation statements)

References 45 publications

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“…Furthermore, Roberts et al [18] reported a lower salivary cortisol response to awakening in 56 CFS patients compared with 35 control individuals. In contrast, Di Giorgio et al [19] found no abnormalities in the levels of plasma cortisol in a sample of 15 CFS patients, although they reported reduced levels of adrenocorticotropic hormone (ACTH) over a full circadian cycle and during the physiological morning peak. Finally, regarding basal hormone concentrations in CSF, Demitrack et al [20] measured cerebrospinal fluid levels of corticotropin-releasing factor (CRF) and ACTH in 19 CFS patients and 26 control individuals, but no differences were apparent.…”

Section: Hpa Axis Disturbances In Cfsmentioning

confidence: 90%

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Eede

Moorkens

Houdenhove³

et al. 2007

Neuropsychobiology

108

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There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS. Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings. Several underlying mechanisms have been proposed. Currently, it is a matter of debate whether these disturbances have a primary role in the pathogenesis of CFS. However, even if the HPA axis dysfunctions are secondary to other factors, they are probably a relevant factor in symptom propagation in CFS.

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Section: Hpa Axis Disturbances In Cfsmentioning

confidence: 90%

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Eede

Moorkens

Houdenhove³

et al. 2007

Neuropsychobiology

108

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“…81,82 The HPA also plays an important role in sleep regulation. 83 Dysregulation of the HPA has been examined using salivary cortisol profiling in a few studies.…”

Section: Hormone Profilesmentioning

confidence: 99%

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ ME) is a chronic, disabling illness that affects approximately 0.2% of the population. Non-restorative sleep despite sufficient or extended total sleep time is one of the major clinical diagnostic criteria; however, the underlying cause of this symptom is unknown. This review aims to provide a comprehensive overview of the literature examining sleep in CFS/ ME and the issues surrounding the current research fi ndings. Polysomnographic and other objective measures of sleep have observed few differences in sleep parameters between CFS/ME patients and healthy controls, although some discrepancies do exist. This lack of signifi cant objective differences contrasts with the common subjective complaints of disturbed and unrefreshed sleep by CFS/ME patients. The emergence of new, more sensitive techniques that examine the microstructure of sleep are showing promise for detecting differences in sleep between patients and healthy individuals. There is preliminary evidence that alterations in sleep stage transitions and sleep instability, and other physiological mechanisms, such as heart rate variability and altered cortisol profi les, may be evident. Future research investigating the etiology of non-restorative sleep in CFS/ME may also help us to undercover the causes of non-restorative sleep and fatigue in other medical conditions. keywords: Chronic fatigue syndrome, myalgic encephalomyelitis, sleep, non-restorative sleep, sleep disorders, fatigue, sleepiness Citation: Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review.

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“…Two studies of plasma cortisol levels were done throughout the nighttime [22,23]. Both reported no significant difference between patients and controls.…”

Section: Discussionmentioning

confidence: 99%

A Subgroup of Patients with Chronic Fatigue Syndrome May Have a Disorder of Arousal~!2009-11-19~!2010-02-23~!2010-04-21~!

Nakamura¹,

Togo²,

Cherniack³

et al. 2010

TOSLPJ

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Abstract:Objective: Patients with chronic fatigue syndrome complain of unrefreshing sleep, and some have poor sleep indicative of sleep disruption. We hypothesized that some CFS patients had a disorder of arousal which interfered with normal sleep which would manifest itself by difficulty falling asleep after a night of sleep deprivation. To test this, we determined sleep latency after a night of sleep deprivation.Methods: Patients and healthy controls, previously habituated to sleeping in a sleep lab, returned for a normal night of sleep and for a night of sleep deprivation followed by determination of latency to fall asleep. Patients also had indwelling catheters to allow repeated sampling of plasma for cortisol, a hormone whose levels might reflect arousal.Results: Five of 15 patients showed delays in falling asleep, relative to the healthy controls. Sleep latency following sleep deprivation correlated inversely with sleep efficiency on the normal sleep night. No significant difference was found in cortisol patterns across time for patients and controls on the sleep deprivation night. However, the slope of the curve was shifted up significantly for patients but not for controls on the normal sleep night. Conclusion:A subgroup of patients has difficulty falling asleep after a night of sleep deprivation. These patients may have a disorder of arousal that interferes with their having normal sleep. CFS patients as a group show a shift upwards in the temporal pattern of cortisol during the night -a possible measure of their being stressed while sleeping.

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24-Hour Pituitary and Adrenal Hormone Profiles in Chronic Fatigue Syndrome

Cited by 48 publications

References 45 publications

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

A Subgroup of Patients with Chronic Fatigue Syndrome May Have a Disorder of Arousal~!2009-11-19~!2010-02-23~!2010-04-21~!

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