24-h pH-metry and Multichannel Intraluminal Impedance Monitoring in Obese Patients with and without Gastroesophageal Reflux Disease Symptoms

Ricci, Giorgio; Amella, C.; Forti, Edoardo; Rossi, Angelo; Bersani, Gianluca; Dari, Silvia; Pasini, V.; Maimone, A.; Alvisi, Vittorio

doi:10.1007/s11695-010-0275-z

Cited by 13 publications

(5 citation statements)

References 18 publications

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“…The prevalence of ERE in this same study was 18.7%, which was higher than that in the general population but lower than that in our sample (38.0%). 21 Similar to other studies, 5,21,27 our results showed a significant relationship (p=0.011) between BMI >35kg/m 2 and ERE. Furthermore, there was a significant correlation between ERE and the DeMeester score (p=0.028), and between ERE and transient LES relaxation (p=0.010), and the variables were strongly and positively correlated and varied simultaneously.…”

Section: Ugesupporting

confidence: 91%

Prevalence of gastroesophageal reflux disease in obese patients eligible for bariatric surgery

Hurtado¹,

Souza²,

Neto³

et al. 2020

GHOA

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Section: Ugesupporting

confidence: 91%

Prevalence of gastroesophageal reflux disease in obese patients eligible for bariatric surgery

Hurtado¹,

Souza²,

Neto³

et al. 2020

GHOA

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“…According to our study, non-acid reflux does not play a role in the relationship between GER and sleep quality in obese children. This is consistent with the report that obese patients have more AGER and GERD but not non-acid reflux as compared to healthy volunteers [ 12 ]. Adult studies showed that a painful stimuli from acid reflux can be associated with arousals and brief awakenings as a protective mechanism, generating secondary peristalsis and facilitating acid clearance.…”

Section: Discussionsupporting

confidence: 93%

“…A higher prevalence of gastroesophageal reflux disease (GERD) and its complications have also been reported in obese patients [ 12 ]. The association of obesity and gastroesophageal reflux (GER) is reported with an odds ratio of 7.3 (95% CI 1.7-31.0) [ 13 14 15 ].…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children

Machado

Woodley

Skaggs

et al. 2016

Pediatr Gastroenterol Hepatol Nutr

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PurposeThis study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children.MethodsStudy subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals.ResultsSleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux.ConclusionThe data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.

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“…Only few studies exist in literature reporting data of the use of 24h MIIpH in obese individuals, but none of them reports normal values. A study from Ricci et al reported increased acid reflux episodes in obese symptomatic and asymptomatic individuals in comparison to non-obese healthy individuals [19]. Recently, Akyuz et al reported the results of 24h MIIpH in asymptomatic obese subjects revealing a positive correlation between BMI and the number of reflux episodes [20].…”

Section: Discussionmentioning

confidence: 97%

“Normal Values of 24H Multichannel Intraluminal Impedance pH-Metry in a Greek Obese Population Based on Montreal Definition of Gerd”

et al. 2015

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Our study is the first to provide normal values of 24h MIIpH of asymptomatic obese. Normal values of 24h MIIpH of obese asymptomatic individuals differ from the reported normal values of non-obese healthy individuals; having more reflux episodes and equal or slightly higher median bolus exposure and acid clearance. Our results imply that new cut-off values should be employed in order to define GERD in obese individuals.

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24-h pH-metry and Multichannel Intraluminal Impedance Monitoring in Obese Patients with and without Gastroesophageal Reflux Disease Symptoms

Cited by 13 publications

References 18 publications

Prevalence of gastroesophageal reflux disease in obese patients eligible for bariatric surgery

Prevalence of gastroesophageal reflux disease in obese patients eligible for bariatric surgery

Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children

“Normal Values of 24H Multichannel Intraluminal Impedance pH-Metry in a Greek Obese Population Based on Montreal Definition of Gerd”

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