24–42 month stability of internal blood standards for glycated hemoglobin analysis

Duck, Stephen C.; Lee, Martha; D’Alessio, Donn J.

doi:10.1016/0168-8227(90)90112-7

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…Patients were also asked to submit a blood sample from each visit with their primary care physician, or every 4 months if no visits were scheduled. Total GHb in the whole blood samples was measured within 7 days of collection by Isolab GlycAffin microcolumn affinity chromatography (Isolab, Akron, OH) as previously described [32]. These serial measurements of total GHb provided information on long-term glucose control.…”

Section: Data Collected Previously As Part Of Wdrsmentioning

confidence: 99%

Factors Associated with Higher Pro-Inflammatory Tumor Necrosis Factor-α Levels in Young Women with Type 1 Diabetes

Danielson

Monson

LeCaire

2016

Exp Clin Endocrinol Diabetes

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Aims While cytokines play a role in the etiology of type 1 diabetes, cytokines later in the disease are less understood. We therefore investigated associations of pro-inflammatory tumor necrosis factor-α levels measured at prolonged disease duration with C-peptide at diagnosis, long-term glycemic control, diabetes duration, clinical factors, and health behaviors. Methods Data and blood were collected during an ancillary study to the longitudinal Wisconsin Diabetes Registry, a population-based cohort followed since diagnosis of type 1 diabetes. The ancillary study was conducted at 13-18 years diabetes duration, and enrolled premenopausal women age 18-45 years (n=87). Results Higher tumor necrosis factor-α levels at 13-18 years diabetes duration were independently associated with longer duration (p=0.0004) and worse current renal function (p=0.02). Additionally, diabetes duration modified both of the positive associations of tumor necrosis factor-α levels (both interactions p≤0.01) with mean glycemic control during the previous 10 years (significant only in women with longer durations) and current daily caffeine intake (significant only in women with shorter durations). In women with C-peptide measured at diagnosis (n=50), higher tumor necrosis factor-α levels at 13-18 years duration were associated with lower C-peptide (p=0.01), independent of glycemic control during the previous 10 years. Conclusions Lower residual C-peptide at diagnosis and poor long-term glycemic control independently predicted higher pro-inflammatory tumor necrosis factor-α levels years later. The novel relationship with C-peptide needs confirmation in a larger cohort. Given the association between tumor necrosis factor-α and diabetes complications, further longitudinal studies may help clarify the potentially complex associations between glycemic control, inflammatory cytokines, and complications.

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Section: Data Collected Previously As Part Of Wdrsmentioning

confidence: 99%

Factors Associated with Higher Pro-Inflammatory Tumor Necrosis Factor-α Levels in Young Women with Type 1 Diabetes

Danielson

Monson

LeCaire

2016

Exp Clin Endocrinol Diabetes

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show abstract

“…Patients also submitted a blood sample from each visit with their primary care physician or every 4 months if no visits were scheduled. Total GHb in the whole blood samples was measured within 7 days of collection by Isolab GlycAffin microcolumn affinity chromatography (Isolab, Akron, OH) as previously described .…”

Section: Methodsmentioning

confidence: 99%

“…À0.008** À0.012* ---10-year GHb slope ---À0.303* À0.296* Age at diagnosis (years) Reproductive history. In controls, mean menstrual cycle length (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and ≥90 days) was positively associated with BAP (U/L, β = 5.77, p = 0.007). For both controls and women with T1DM, oestrogen + progesterone hormonal contraceptive use (never/former/current) was negatively associated with markers of bone formation, including osteocalcin (ng/mL, controls: β = À1.08, p < 0.0001; T1DM: β = À0.92, p < 0.0001) and BAP (U/ L, controls: β = À5.24, p < 0.0001; T1DM: β = À2.84, p = 0.006).…”

Section: Multivariable Modelsmentioning

confidence: 99%

Different health behaviours and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes

Kujath

Quinn

Elliott

et al. 2015

Diabetes Metabolism Res

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Background Women with type 1 diabetes (T1DM) have an elevated fracture risk. We therefore compared the associations of health behaviors and clinical factors with bone mineral density (BMD) and bone remodeling between premenopausal women with and without T1DM to inform potential interventions. Methods Participants included women with T1DM (n=89) from the Wisconsin Diabetes Registry Study and age- and race-matched controls without diabetes (n=76). Peripheral (heel, forearm) and central (hip, spine) BMD, markers of bone resorption and formation, bone cell signaling, glycemic control, and kidney function were assessed. Health behaviors and medical history were self-reported. Results In controls, but not in women with T1DM, older age was associated with lower bone resorption (p≤0.006) and formation (p=0.0007). Body mass index (BMI) was positively associated with heel and forearm BMD in both controls and T1DM women (all p<0.0001), but with hip and spine BMD only in controls (p≤0.005). Worse glycemic control during the previous 10 years, greater alcohol intake, history of smoking, and lack of physical activity were associated with poorer bone outcomes only in women with T1DM (all p≤0.002); whereas use of hormonal contraceptives was related to low bone formation in both women with and without T1DM (all p≤0.006). Diabetes duration, insulin dose, residual C-peptide, and kidney function were not associated with bone in T1DM. Conclusions Age and BMI may not predict bone health in T1DM women. However modifiable behaviors such as optimizing glycemic control, limiting substance and hormonal contraceptive use, and increasing physical activity may improve bone health in T1DM women.

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“…Prestamped mailing kits containing 5-ml EDTA-treated vacutainers were provided. Whole blood samples were analyzed for total GHb level within seven days of collection by Isolab GlycAffin microcolumn affinity chromatography (Isolab, Akron, OH) [26]. Internal standards from nondiabetic children and young adults had a mean (SD) total GHb level of 5.5 (0.8)%.…”

Section: Methodsmentioning

confidence: 99%

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

et al. 2008

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Introduction Low BMD and fracture may be complications of type 1 diabetes. We sought to determine the roles of bone turnover and glycemic control in the etiology of low BMD. Methods Premenopausal women from the Wisconsin Diabetes Registry Study and matched controls were compared (n=75 pairs). Heel and forearm BMD were measured, and hip and spine BMD were measured in a subset. Markers of bone formation (osteocalcin) and resorption (NTx), and glycemic control (HbA1c) were determined. Results Age ranged from 18–50 years with a mean of 28, and 97% were Non-Hispanic white. Among women with diabetes, mean disease duration was 16 years and current HbA1c was 8%. Compared to controls, women with diabetes had a high prevalence of previous fracture (37% vs. 24%) and low BMD for age (heel or forearm: 49% vs. 31%), low heel and forearm BMD, and low osteocalcin levels. Levels of NTx were similar, suggesting uncoupled turnover favoring resorption. Poor glycemic control was associated with low BMD at all bone sites except the spine, and with low osteocalcin and NTx levels. Conclusions Optimal glycemic control may prevent low BMD and altered bone turnover in type 1 diabetes, and decrease fracture risk.

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24–42 month stability of internal blood standards for glycated hemoglobin analysis

Cited by 11 publications

References 17 publications

Factors Associated with Higher Pro-Inflammatory Tumor Necrosis Factor-α Levels in Young Women with Type 1 Diabetes

Factors Associated with Higher Pro-Inflammatory Tumor Necrosis Factor-α Levels in Young Women with Type 1 Diabetes

Different health behaviours and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

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