Methemoglobin levels in umbilical cord blood of women with intrauterine growth restriction and preeclampsia

Yusuf, Korede K; Wilson, R. Douglas; Kamaluddeen, Majeeda; Franta, Jan; Hasan, SU; Akierman, Albert

doi:10.3109/14767058.2013.838949

Cited by 4 publications

(1 citation statement)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an investigation of 68 healthy newborns, FHbF values ranging from 74.3-94.3% (with an average of 85.5%) were measured by chromatography [21]. Across 42 healthy pregancies, an average cord blood methemoglobin fraction of 1.27±0.03% was reported in a recent study [22].…”

Section: Cord Blood Specimen Propertiesmentioning

confidence: 99%

Relaxation properties of human umbilical cord blood at 1.5 Tesla

et al. 2016

View full text Add to dashboard Cite

Purpose-To characterize the MRI relaxation properties of human umbilical cord blood at 1.5 Tesla.Methods-Relaxometry measurements were performed on cord blood specimens (N=88, derived from 6 caesarean deliveries) spanning a broad range of hematocrits (Hct=0.19-0.76) and oxygen saturations (sO 2 =4-100%), to characterize the dependence of T 1 and T 2 on these blood properties.Adult blood data (N = 31 specimens, derived from two volunteers) were similarly studied to validate our experimental methods by comparison with existing literature. Using biophysical models previously developed for adult blood, new model parameters were estimated, which relate Hct and sO 2 to the observed cord blood relaxation times.Results-Fitted biophysical models explained more than 90% of the variation in T 1 and T 2 . In general, T 2 relaxation times of cord blood were longer (by up to 35%) than those of adult blood, while T 1 relaxation times were slightly shorter (by up to 10%).Conclusion-The models and fitted parameters presented here can be used for calibration of future MRI investigations of fetal and neonatal blood physiology. This study is an important step in facilitating accurate, non-invasive assessments of fetal blood oxygen content, a valuable diagnostic parameter in the identification and treatment of fetal hypoxia.

show abstract

Section: Cord Blood Specimen Propertiesmentioning

confidence: 99%