Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers

Abstract

This study evaluated the effects of 10-day broccoli (250 g/day) intake on dietary markers and markers of inflammations in young male smokers. A dietary intervention study with a repeated measures crossover design was conducted. Circulating levels of carotenoids, folate, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 6 receptor (IL-6sR) and adiponectin were measured. Broccoli intake significantly increased plasma levels of folate (+17%) and lutein (+39%), while no significant effect was observed for TNF-α, IL-6, IL-6sR or adiponectin. Plasma CRP decreased by 48% (post-hoc analysis, p < 0.05) following broccoli diet; this resulted to be independent from the plasma variations in lutein and folate. An inverse correlation between lycopene, TNF-α and IL-6sR was observed at baseline. In conclusion, broccoli consumption may reduce CRP levels in smokers, consistent with epidemiologic observations that fruit and vegetable intake is associated with lower circulating CRP concentrations.

Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects

“…Our research group has previously described a significant decrease on markers of inflammatory processes, as the metabolites tetranor-PGEM (from prostaglandins E 1 and E 2 ) and 11 β-PGF2α (from prostaglandin D2) after consumption of a single portion of broccoli sprouts [20]. Other authors have reported decreases on Creactive protein levels by 48 % after 10-day broccoli intake (250 g/day) in smokers, confirming our results; however, no changes on IL-6 levels were detected [21].…”

Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study

“…In an RCT, Estevez-Santiago et al, also reported no significant change in CRP levels after daily supplementation of 6 mg lutein and 2 mg zeaxanthin in healthy female participants; however, there was no information on smoking status [ 25 ]. Nevertheless, Riso et al, observed by post hoc analysis that 10 day supplementation with broccoli (each portion [250 g] provided 3.1 mg of lutein, 1.4 mg of β-carotene, and 146 mg of vitamin C) decreased CRP levels in young healthy smokers [ 26 ]. In our previous study, smoking was not associated with serum lutein or zeaxanthin concentrations [ 18 ].…”

Healthy Hunger-Free Kids Act Increases Phytochemicals in Menus and Curriculum Furthers Identification of Phytochemical-Rich Foods

“…A study conducted over a two-week period demonstrated that the daily addition of only two cups of a Mediterranean soup containing approximately 13.3 mg carotenoids and 78 mg vitamin C significantly decreased various markers of inflammation and oxidative stress [24]. Furthermore, a study by Riso et al [25]. Found that ten day consumption of approximately 1.6 cups of cooked broccoli among smokers decreased CRP levels, which again demonstrates that small increases in fruit and vegetable intake can positively impact biomarkers in a short amount of time.…”