Contact dermatitis to vitamin K1 in an eye cream

López‐Lerma, Ingrid; Vilaplana, J

doi:10.1016/j.anai.2013.06.017

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…In the past, many cases of allergic contact dermatitis caused by topical vitamin K were reported in Italy, Spain, and France (11–15) (Table S1), which is why vitamin K was banned from use in cosmetic products in the EU in 2009 (16). The intention has been to use vitamin K 1 oxide (CAS no.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

et al. 2017

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“…To date, few cases of allergic contact dermatitis from topical vitamin K 1 have been described . Phytonadione (INN: phytomenadione), with the chemical name 2‐methyl‐3‐(3,7,11,15‐tetramethyl‐2‐hexadecenyl)‐1,4‐naphthalenedione, is one of the two natural isoforms of vitamin K. The structure of vitamin K 1 (phylloquinone), is characterized by the presence of a phytyl group.…”

Section: Discussionmentioning

confidence: 99%

Vitamin K₁ photo‐induced reaction during treatment with cetuximab

et al. 2019

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A 63-year-old woman with a metastatic colorectal cancer presented with a 5-day history of an erythematous itching vesicular eruption on photo-exposed areas of the face (Figure 1). During the previous 12 months the patient underwent 13 intravenous chemotherapy cycles with cetuximab 375 mg in combination with irinotecan 270 mg, fluorouracile (5FU) 600 mg, and folic acid 150 mg every 2 weeks, with no reported adverse drug reactions. Dermatitis developed during the last cycle of chemotherapy and after the application of a skin cream containing 0.1% vitamin K 1 (VigorSkinK1, Merck Serono, Italy). The patient was exposed to the sun during her daily outdoor activities and 10 days after the application of the vitamin K 1 cream the photo-induced reaction commenced. Patch tests with the SIDAPA (Società Italiana di Dermatologia Allergologica Professionale ed Ambientale) baseline and cosmetic series (Firma Diagent, Florence, Italy) were applied to the back with Finn Chambers (SmartPractice, Phoenix, Arizona) on Scanpor tape (Norgesplaster, Vennesla, Norway) and readings were taken on day (D) 2, D4, and D7. All patch tests were negative. Photopatch tests were performed with the standard SIDAPA photopatch series (Euromedical, Calolziocorte Lecco, Italy), the commercial cream VigorSkinK 1 "as is", and Konakion (aqueous solution 1 mg/mL, Cheplapharm Arzneimittel, Mesekenhagen, Germany).The allergens on the left side of the back were covered with an ultraviolet (UV) radiation-opaque material, and those on the right side were irradiated with 4 J/cm 2 UVA light (Waldmann UV, 801 KL Phototherapy, Herbert Waldmann, Villingen-Schwenningen, Germany). Readings were performed on D2, D4, and D7 according to ESCD guidelines.

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“…Although ACD caused by cosmetic products containing the non‐oxidized form of vitamin K 1 have been widely reported, since it was banned in 2009 only 6 cases of ACD caused by products containing phytonadione epoxide have been observed, with contact allergy to this compound being shown in 4 cases. Although phytonadione oxide has been patch tested in 2 different concentrations (1% and 5% pet.)…”

Section: Discussionmentioning

confidence: 99%

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁

et al. 2018

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Contact dermatitis to vitamin K1 in an eye cream

Cited by 7 publications

References 2 publications

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Vitamin K₁ photo‐induced reaction during treatment with cetuximab

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁

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Contact dermatitis to vitamin K1 in an eye cream

Cited by 7 publications

References 2 publications

Erythema multiforme‐like reaction resulting from vitamin K1 oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K1 oxide (phytomenadione epoxide)

Vitamin K1 photo‐induced reaction during treatment with cetuximab

“Crossed” allergic contact dermatitis caused by oxidized vitamin K1 in a patient previously sensitized to non‐oxidized vitamin K1

Contact Info

Product

Resources

About

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Vitamin K₁ photo‐induced reaction during treatment with cetuximab

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁