Serum hepatocyte growth factor is associated with truncal fat mass and increased mortality in chronic kidney disease stage 5 patients with protein-energy wasting

Yuan, Jiangzi; Watanabe, Makoto; Suliman, Mohamed E.; Qureshi, Abdul Rashid; Axelsson, Jonas; Bárány, Peter; Heimbürger, Olof; Stenvinkel, Peter; Lindholm, Bengt

doi:10.1093/ndt/gft265

Cited by 10 publications

(9 citation statements)

References 38 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human studies have shown that n -3 PUFA status in body tissues reflects oral intake [ 19 ] and that following incorporation in biological membranes, n -3 PUFA specifically activate cardiovascular protective signaling pathways [ 20 ], resulting in increased NO production [ 21 ], reduced oxidative stress [ 18 , 22 ] and blunted inflammation [ 23 ]. Clinical epidemiological studies have demonstrated a significant association between reduced n -3 PUFA consumption and the risk of ischemic heart disease [ 24 ], suggesting that n -3 PUFA replacement may improve clinical outcomes in high-risk populations.…”

Section: Discussionmentioning

confidence: 99%

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

et al. 2017

View full text Add to dashboard Cite

Background: Endothelial dysfunction is a key vascular alteration in chronic kidney disease (CKD). Omega 3 (n-3) polyunsaturated fatty acids (PUFA) reduce vascular oxidative stress and inflammation. We investigated whether n-3 PUFA could reverse endothelial dysfunction in CKD by improving endothelial nitric oxide synthase (eNOS) function and oxidative stress. Methods: 5/6 nephrectomized male Wistar rats (CKD; n = 10) and sham operated animals (SHAM; n = 10) were treated for 6 weeks with standard diet. An additional group of CKD rats were fed an n-3 PUFA enriched diet (CKD + PUFA; n = 10). We then measured endothelium-dependent (EDD) and -independent vasodilation, markers of endothelial function and of oxidative stress in thoracic aortas. Results: Compared to SHAM, in CKD aortas EDD and eNOS expression were reduced (p < 0.05) and 3-nitrotyrosine levels were increased, while expression of NADPH oxidase subunits NOX4 and p22phox was similar. In-vitro incubation with Tiron failed to reverse endothelial dysfunction in CKD. In CKD + PUFA, EDD improved (p < 0.05) compared with CKD rats, while blockade of eNOS by L-NAME worsened EDD. These effects were accompanied by increased (p < 0.05) eNOS and reduced (p < 0.05) expression of NOX4 and 3-nitrotyrosine levels. Conclusion: Collectively, these findings indicate that n-3 PUFA improve endothelial dysfunction by restoring NO bioavailability in CKD.

show abstract

Section: Discussionmentioning

confidence: 99%

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

et al. 2017

View full text Add to dashboard Cite

show abstract

“…During recent years, mortality-related factors, such as body composition, have been studied in patients with CKD [5, 6]. The association between body mass index (BMI) and mortality remains unclear in advanced CKD.…”

Section: Introductionmentioning

confidence: 99%

Low lean tissue mass is an independent risk factor for mortality in patients with stages 4 and 5 non-dialysis chronic kidney disease

Vega¹,

Abad²,

Macías³

et al. 2017

Clinical Kidney Journal

View full text Add to dashboard Cite

Background: Mortality in patients with stages 4 and 5 chronic kidney disease (CKD) is higher than in the general population. Body composition predicts mortality. Our objective was to evaluate the effect of body composition on mortality in patients with stages 4 and 5 non-dialysis CKD. Methods: We performed a prospective study of 356 patients with stages 4 and 5 non-dialysis CKD. At baseline, we recorded general characteristics, history of cardiovascular events, body composition, serum inflammatory markers, nutrition and cardiac biomarkers. Body composition was analysed using bioimpedance spectroscopy. We recorded the lean tissue index (LTI), fat tissue index (FTI) and overhydration (OH). During a median (range) follow-up of 22 (3–49) months, we recorded mortality, cardiovascular events and progress to renal replacement therapy. Results: At baseline, mean (± standard deviation) age was 67 ± 13 years (men 64%; diabetes 36%). Mean body mass index was 28.2 ± 12.8 kg/m2, the FTI was 12.3 ± 5.6 kg/m2, the LTI was 15.7 ± 3.4 kg/m2 and median (interquartile range) OH was 0.6 (−0.4 to 1.5) L. Sixty-four (18%) patients died during follow-up. The univariate Cox analysis showed an association between mortality and age, low LTI, high Charlson comorbidity index, previous cardiovascular events, OH, low albumin and prealbumin levels, and high C-reactive protein levels. Kaplan–Meier analysis revealed higher survival in patients with a higher LTI (log-rank, 9.47; P = 0.002). The multivariate Cox analysis confirmed an association between mortality and low LTI (P = 0.031), previous cardiovascular events (P = 0.003) and high Charlson comorbidity index (P = 0.01). We did not find any association between body composition and cardiovascular events or renal replacement therapy. Conclusions: A low LTI is an independent factor for mortality in patients with stages 4 and 5 CKD.

show abstract

“…Several studies have reported that serum HGF is associated with increased mortality in patients with CKD 16 , but the role of soluble cMet levels in predicting renal failure has not been studied in detail. In addition, there are no data regarding urinary soluble cMet levels.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study demonstrated that elevated serum HGF levels in the presence of protein-energy wasting increased all-cause mortality risk in ESRD patients 16 ; moreover, HGF could predict all-cause mortality and cardiovascular mortality in the general population 17 . Several studies showed that urinary HGF is not only a prognostic biomarker in CKD 18 , 19 but also useful in clinical risk prediction for recovery after acute kidney injury (AKI) 20 , 21 , especially in critically ill patients 22 and kidney transplant recipients 23 .…”

Section: Introductionmentioning

confidence: 99%

Soluble cMet levels in urine are a significant prognostic biomarker for diabetic nephropathy

Kim

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Hepatocyte growth factor and its receptor cMet activate biological pathways necessary for repair and regeneration following kidney injury. Here, we evaluated the clinical role of urinary cMet as a prognostic biomarker in diabetic nephropathy (DN). A total of 218 patients with DN were enrolled in this study. We examined the association of urine cMet levels and long-term outcomes in patients with DN. The levels of urinary cMet were higher in patients with decreased renal function than in patients with relatively preserved renal function (5.25 ± 9.62 ng/ml versus 1.86 ± 4.77 ng/ml, P = 0.001). A fully adjusted model revealed that a urinary cMet cutoff of 2.9 ng/mL was associated with a hazard ratio for end-stage renal disease of 2.33 (95% confidence interval 1.19–4.57, P = 0.014). The addition of urinary cMet to serum creatinine and proteinuria provided the highest net reclassification improvement. We found that in primary cultured human glomerular endothelial cells, TGFβ treatment induced fibrosis, and the protein expression levels of collagen I, collagen IV, fibronectin, and αSMA were decreased after administration of an agonistic cMet antibody. In conclusion, elevated levels of urinary cMet at the time of initial diagnosis could predict renal outcomes in patients with DN.

show abstract

Serum hepatocyte growth factor is associated with truncal fat mass and increased mortality in chronic kidney disease stage 5 patients with protein-energy wasting

Abstract: Increased TFMI was an independent predictor of HGF in CKD stage 5 patients. Moreover, an elevated HGF level increased the mortality risk in the presence of PEW. These results suggest a central role of HGF in the metabolic and nutritional alterations in CKD stage 5 patients.

Cited by 10 publications

References 38 publications

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Low lean tissue mass is an independent risk factor for mortality in patients with stages 4 and 5 non-dialysis chronic kidney disease

Soluble cMet levels in urine are a significant prognostic biomarker for diabetic nephropathy

Contact Info

Product

Resources

About